Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels

Journal of Biochemistry

Volumn 139, Issue 3, 2006, Pages 449-458

  Ebihara, Tatsuhiko ^a,c   Guo, Feifan ^a,d   Zhang, Lei ^a,e   Kim, Ju Young ^b,f   Saffen, David ^a,b,g  

^a UNIVERSITY OF TOKYO   (Japan)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium; Carbachol; Muscarinic acetylcholine receptor; PC12D; Thapsigargin

Indexed keywords

ATROPINE; CALCIUM CHANNEL; CARBACHOL; MANGANESE; MUSCARINIC RECEPTOR; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL ACTIVITY; CONTROLLED STUDY; NONHUMAN; PERMEABILITY; RAT;

ANIMALS; CALCIUM; ION CHANNEL GATING; ION CHANNELS; PC12 CELLS; RATS; RECEPTORS, MUSCARINIC;

ANIMALIA;

EID: 33646366931     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj064     Document Type: Article

References (32)

1. Levey, A.I. (1996) Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease. Proc. Natl. Acad. Sci. USA 93, 13541-13546
2. Marino, M.J., Rouse, S.T., Levey, A.I., Potter, L.T., and Conn, P.J. (1998) Activation of the genetically denned m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc. Natl. Acad. Sci. USA 95, 11465-11470
3. Anagnostaras, S.G., Murphy, G.G., Hamilton, S.E., Mitchell, S.L., Rahnama, N.P., Nathanson, N.M., and Silva, A.J. (2003) Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat. Neurosci. 6, 51-58
4. Lane, R.M., Potkin, S.G., and Enz, A. (2005) Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int. J. Neuropsychopharmacol. 1-24
5. Ebihara, T. and Saffen, D. (1997) Muscarinic acetylcholine receptor-mediated induction of zif268 mRNA in PC12D cells requires protein kinase C and the influx of extracellular calcium. J. Neurochem. 68, 1001-1010
6. Kumahara, E., Ebihara, T., and Saffen, D. (1999) Protein kinase inhibitor H7 blocks the induction of immediate-early genes zif268 and c-fos by a mechanism unrelated to inhibition of protein kinase C but possibly related to inhibition of phosphorylation of RNA polymerase II. J. Biol. Chem. 274, 10430-10438
7. Hirabayashi, T. and Saffen, D. (2000) M1 muscarinic acetylcholine receptors activate zif268 gene expression via small G-protein Rho-dependent and lambda-independent pathways in PC12D cells. Eur. J. Biochem. 267, 2525-2532
8. Guo, F.F., Kumahara, E., and Saffen, D. (2001) A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. J. Biol. Chem. 276, 25568-25581
9. 2+ influx and redistribution. Biochem. J. 234, 547-553
10. 2+. Proc. Natl. Acad. Sci. USA 89, 509-513
11. Mathes, C. and Thompson, S.H. (1994) Calcium current activated by muscarinic receptors and thapsigargin in neuronal cells. J. Gen. Physiol. 104, 107-121
12. i oscillations in HEK293 cells. J. Biol. Chem. 276, 5613-5621
13. Putney, J.W., Jr. (1986) A model for receptor-regulated calcium entry. Cell Calcium 7, 1-12
14. Berridge, M.J. (1995) Capacitative calcium entry. Biochem. J. 312(Pt 1), 1-11
15. Parekh, A.B. and Penner, R. (1997) Store depletion and calcium influx. Physiol. Rev. 77, 901-930
16. 2+ signalling requirements. Biochem. J. 337(Pt 2), 153-169
17. Putney, J.W., Jr., Broad, L.M., Braun, F.J., Lievremont, J.P., and Bird, G.S. (2001) Mechanisms of capacitative calcium entry. J. Cell Sci. 114, 2223-2229
18. Putney, J.W., Jr. (2004) The enigmatic TRPCs: multifunctional cation channels. Trends Cell Biol. 14, 282-286
19. 2+-ATPaSe. Proc. Natl. Acad. Sci. USA 87, 2466-2470
20. Lytton, J., Westlin, M., and Hanley, M.R. (1991) Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266, 17067-17071
21. 2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells. J. Biol. Chem. 267, 2164-2172
22. Katoh-Semba, R., Kitajima, S., Yamazaki, Y., and Sano, M. (1987) Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factor. J. Neurosci. Res. 17, 36-44
23. van Koppen, C.J. and Kaiser, B. (2003) Regulation of muscarinic acetylcholine receptor signaling. Pharmacol. Ther. 98, 197-220
24. 2+ accumulation, storage, and release. J. Biol. Chem. 266, 20159-20167
25. Takemura, H., Hughes, A.R., Thastrup, O., and Putney, J.W., Jr. (1989) Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane. J. Biol. Chem. 264, 12266-12271
26. Merritt, J.E., Jacob, R., and Hallam, T.J. (1989) Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils. J. Biol. Chem. 264, 1522-1527
27. Jacob, R. (1990) Agonist-stimulated divalent cation entry into single cultured human umbilical vein endothelial cells. J. Physiol. 421, 55-77
28. 2+ influx pathways couple acetylcholine receptor activation to catecholamine secretion from PC12 cells. J. Neurochem. 75, 1583-1589
29. Neher, E., Marty, A., Fukuda, K., Kubo, T., and Numa, S. (1988) Intracellular calcium release mediated by two muscarinic receptor subtypes. FEBS Lett. 240, 88-94
30. 2+ without generation of inositol phosphates in NG115-401L neuronal cells. Biochem. J. 253, 81-86
31. 2+ sensitivities. Cell Calcium 13, 293-301
32. 2+ mobilizing mechanisms in cultured rat cerebellar granule cells. J. Physiol. 456, 667-680