Aprotinin in cardiac surgery [7]

New England Journal of Medicine

Volumn 354, Issue 18, 2006, Pages 1953-1954

  Ferraris, Victor A ^a   Bridges, Charles R ^b   Anderson, Richard P ^c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c VIRGINIA MASON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTICOAGULANT AGENT; ANTIFIBRINOLYTIC AGENT; APROTININ; INOTROPIC AGENT; TRANEXAMIC ACID; SERINE PROTEINASE INHIBITOR; AMINOCAPROIC ACID DERIVATIVE;

BLEEDING; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CARDIOVASCULAR RISK; CLINICAL TRIAL; DRUG INDICATION; EVIDENCE BASED PRACTICE; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART SURGERY; HUMAN; HYPOTENSION; KIDNEY FAILURE; LETTER; META ANALYSIS; PATIENT SELECTION; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; STROKE; SURGICAL MORTALITY; SYSTEMATIC REVIEW; METHODOLOGY; NOTE; POSTOPERATIVE HEMORRHAGE; CONFLICT OF INTEREST; EPIDEMIOLOGY; WRITING; CHEMICALLY INDUCED DISORDER; DIABETES MELLITUS; KIDNEY DISEASE; RENAL REPLACEMENT THERAPY;

APROTININ; CARDIAC SURGICAL PROCEDURES; HUMANS; POSTOPERATIVE HEMORRHAGE; RESEARCH DESIGN; SERINE PROTEINASE INHIBITORS; AUTHORSHIP; CAUSALITY; CONFLICT OF INTEREST; DIABETES COMPLICATIONS; KIDNEY DISEASES; RENAL DIALYSIS; AMINOCAPROIC ACIDS; META-ANALYSIS;

EID: 33646365664     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc066081     Document Type: Letter

References (5)

1. Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006;354:353-65.
2. Mangano DT. Aspirin and mortality from coronary bypass surgery. N Engl J Med 2002;347:1309-17.
3. Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med 1998;128:194-203.
4. Sedrakyan A, Treasure T, Elefteriades JA. Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 2004;128:442-8.
5. Henry DA, Moxey AJ, Carless PA, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2001;1:CD001886.