Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes

Journal of Cellular Physiology

Volumn 207, Issue 3, 2006, Pages 605-613

  Chipitsyna, Galina ^a   Sawaya, Bassel E ^a   Khalili, Kamel ^a   Amini, Shohreh ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CELL PROTEIN; RAD51 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; ASTROCYTE; CHROMOSOME ABERRATION; COMPLEX FORMATION; DNA PROBE; DNA REPAIR; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; VIRUS GENE; VIRUS GENOME;

ASTROCYTES; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; GENE PRODUCTS, TAT; GENOME, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; PROMOTER REGIONS (GENETICS); RAD51 RECOMBINASE; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33646355164     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20612     Document Type: Article

References (52)

1. Abraham S, Sawaya BE, Safak M, Batuman O, Khalili K, Amini S. 2003. Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells. Virology 309:196-202.
2. Abraham S, Sweet T, Sawaya BE, Rappaport J, Khalili K, Amini S. 2005. Cooperative interaction of C/EBPβ and Tat modulates MCP-1 gene transcription in astrocytes. J Neuroimmunol 16:219-227.
3. Ahmad N, Venkatesan S. 1988. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 241:1481-1485.
4. Amini S, Saunders M, Kelley K, Khalili K, Sawaya BE. 2004. Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes. J Biol Chem 279:46046-46056.
5. Aten JA, Stap J, Krawczyk PM, van Oven CH, Hoebe RA, Essers J, Kanaar R. 2004. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains Science 303:92-95.
6. Barber SA, Herbst DS, Bullock BT, Gama L, Clements JE. 2004. Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system. J Neurovirol 10(suppl 1):15-20.
7. Baumann P, Benson FE, West SC. 1996. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87:757-766.
8. Benson FE, Stasiak A, West SC. 1994. Purification and characterization of the human Rad51 protein, an analogue of E.coli RecA. EMBO J 13:5764-5771.
9. Cassel TN, Nord M. 2003. C/EBP transcription factors in the lung epithelium. Am J Physiol Lung Cell Mol Physiol 285:L773-L781.
10. Chen F, Natasi A, Shen Z, Brenneman M, Crissman H, Chen DJ. 1997. Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52. Mutat Res 384:205-211.
11. Chipitsyna G, Slonina D, Siddiqui K, Peruzzi F, Skorski T, Reiss K, Sawaya BE, Khalili K, Amini S. 2004. HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression. Oncogene 23:2664-2671.
12. Cooney AJ, Tsai SY, O'Malley BW, Tsai MJ. 1991. Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long termina repeat. J Virol 65:2852-2860.
13. Coyle-Rink J, Sweet T, Abraham S, Sawaya B, Batuman O, Khalili K, Amini S. 2002. Interaction between TGFbeta signaling proteins and C/EBP controls basal and Tat-mediated transcription of HIV-1 LTR in astrocytes. Virology 299:240-247.
14. Cullen BR. 1990. The HIV-1 Tat protein: An RNA sequence-specific processivity factor. Cell 63:655-657.
15. Desai-Yajnik V, Samuels HH. 1993. The NF-(B and Sp1 motifs of the human immunodeficiency virus type 1 long terminal repeat function as novel thyroid hormone response elements. Mol Cell Biol 13:5057-5069.
16. Gallia GL, Darbinian N, Tretiakova A, Ansari S, Rappaport J, Brady J, Wortman MJ, Johnson EM, Khalili K. 1999. Association of HIV-1 Tat with the cellular protein, Purot, is mediated by RNA. Proc Natl Acad Sci USA 96:11572-11577.
17. Gee CJ, Harris H. 1979. Tumorigenicity of cells transformed by simian virus 40 and of hybrids between such cells and normal diploid cells. J Cell Sci 36:223-240.
18. Gupta RC, Bazemore LR, Golub EI, Radding CM. 1997. Activities of human recombination protein Rad51. Proc Natl Acad Sci USA 94:463-468.
19. Harrich D, Garcia J, Wu F, Mitsuyasu R, Gonzalez J, Gaynor R. 1989. Role of Sp1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J Virol 63:2585-2591.
20. Herrmann CH, Rice AP. 1995. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxylterminal domain of the large subunit of RNA polymerasell: Candidate for a Tat cofactor. J Virol 69:1612-1620.
21. Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum R, Kufe D, Yuan ZM. 1999. Role of caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol Cell Biol 19:2986-2997.
22. Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H. 1993. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J Virol 67:6224-6233.
23. Kanamoto T, Hellman U, Heldin CH, Souchelnytskyi S. 2002. Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. EMBO J 21:1219-1230.
24. Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA. 2005. HIV-1 infection and AIDS: Consequences for the central nervous system. Cell Death Differ 12:878-892.
25. Kowenz-Leutz E, Leutz A. 1999. A C/EBPβ isoform recruits the SW1/SNF complex to activate myeloid genes. Mol Cell 4:735-743.
26. Lavrrar JL, Farnham PJ. 2004. The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation. J Biol Chem 279:46343-46349.
27. Levine AJ. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
28. Lotem J, Sachs L. 1993. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 4:41-47.
29. Lubbert M, Mirro J Jr., Kitchingman G, McCormick F, Mertelsmann R, Herrmann F, Koeffler HP. 1992. Prevalence of N-ras mutations in children with myelodysplastic syndromes and acute myeloid leukemia. Oncogene 7: 263-268.
30. Marcello A, Lusic M, Pegoraro G, Pellegrini V, Beltram F, Giacca M. 2004. Nuclear organization and the control of HIV-1 transcription. Gene 326:1-11.
31. Morris KV, Rossi JJ. 2004. Anti-HIV-1 gene expressing lentiviral vectors as an adjunctive therapy for HIV-1 infection. Curr HIV Res 2:185-191.
32. Muchardt C, Yaniv M. 1993. A human homologue of Saccharomyces cerevisiae SNF2/SW12 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J 12:4279-4290.
33. Mufson RA, Myers C, Turpin JA, Meltzer M. 1992. Phorbol ester reduces constitutive nuclear NFKB and inhibits HIV-1 production in mature human monocytic cells. J Leukoc Biol 52:637-664.
34. Parrott C, Seidner T, Duh E, Leonard J, Theodore TS, Buckler-White A, Martin MA, Rabson AB. 1991. Variable role of the long terminal repeat of Sp1-binding sites in human immunodeificiency virus replication in T lymphocytes. J Virol 65:1414-1419.
35. Pereira LA, Bentley K, Peeters A, Churchill MJ, Deacon NJ. 2000. A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter. Nucl Acids Res 28:663-668.
36. Perkins ND, Edwards NL, Duckett CS, Agranoff AB, Schmid RM, Nabel GJ. 1993. A cooperative interaction between NFKB and Sp1 is required for HIV-1 enhancer activation. EMBO J 12:3551-3558.
37. Proudfoot NJ, Lee BA, Monks J. 1992. Multiple Sp1 binding sites confer enhancer-independent, replication-activated transcription of HIV-1 and globin gene promoters. New Biol 4:369-381.
38. Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M. 2003. HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24:224-237.
39. Rappaport J, Joseph J, Croul S, Alexander G, Del Valle L, Amini S, Khalili K. 1999. Molecular pathways involved in HIV-1 induced CNS pathology: Role of viral regulatory protein, Tat. J Leukoc Biol 65:458-465.
40. Rice AP, Herrmann CH. 2003. Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. Curr HIV Res 1:395-404.
41. Richardson C. 2005. RAD51, genomic stability, and tumorigenesis. Cancer Lett 218:127-139.
42. Rohr O, Marban C, Aunis D, Schaeffer E. 2003. Regulation of HIV-1 gene transcription: From lymphocytes to microglial cells. J Leukoc Biol 74:736-749.
43. Saintigny Y, Duamy A, Lambert S, Lopez BS. 2001. A novel role for the Bcl-2 protein family: Specific suppression of the RAD51 recombination pathway. EMBO J 20:2596-2607.
44. Sawaya BE, Thatikunta P, Denisova L, Brady J, Khalili K, Amini S. 1998. Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells. J Neuroimmunol 87:33-42.
45. Schwartz C, Catez P, Rohr O, Lecestre D, Aunis D, Schaeffer E. 2000. Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells. J Virol 74: 65-73.
46. Taylor JP, Pomerantz R, Bagasra O, Chowdhury M, Rappaport J, Khalili K, Amini S. 1992. TAR-independent transactivation by Tat in cells derived from the CNS: A novel mechanism of HIV-1 gene regulation. EMBO J 11:3395-3403.
47. Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. 1996. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 16:1479-1489.
48. Ubeda M, Vallejo M, Habener JF. 1999. CHOP enhancement of gene transcription by interaction with Jun/Fos AP-1 complex proteins. Mol Cell Biol 19:7589-7599.
49. Vogelstein B, Civin cI, Preisinger AC, Krischer JP, Steuber P, Ravindranath Y, Weinstein H, Elfferich P, Bos J. 1990. RAS gene mutations in childhood acute myeloid leukemia: A Pediatric Oncology Group study. Genes Chromosomes Cancer 2:159-162.
50. Wang XZ, Ron D. 1996. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272:1347-1349.
51. Xia SJ, Shammas MA, Shmookler-Reis RJ. 1997. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol Cell Biol 17:7151-7158.
52. Yamamoto A, Taki T, Yagi H, Habu T, Yoshida K, Yoshimura Y, Yamamoto K, Matsuhiro A, Nishimune Y, Morita T. 1996. Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet 251:1-12.