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Volumn 353, Issue 1, 2006, Pages 75-82

A high-throughput assay for a human telomerase protein-human telomerase RNA interaction

Author keywords

High throughput screen; Scintillation proximity assay; Telomerase; Telomerase assemblage; Telomerase RNA; Telomere

Indexed keywords

CHROMOSOMES; COENZYMES; DISEASES; SCINTILLATION;

EID: 33646353663     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2006.03.027     Document Type: Article
Times cited : (7)

References (53)
  • 2
    • 0015844590 scopus 로고
    • A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov A.M. A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41 (1973) 181-190
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 3
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • Watson J.D. Origin of concatemeric T7 DNA. Nat. New Biol. 239 (1972) 197-201
    • (1972) Nat. New Biol. , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 4
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli D., Young J.W., and de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92 (1995) 9082-9086
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    de Lange, T.3
  • 6
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., and Shay J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18 (1996) 173-179
    • (1996) Dev. Genet. , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 7
    • 0031036132 scopus 로고    scopus 로고
    • Telomerase activity concentrates in the mitotically active segments of human hair follicles
    • Ramirez R.D., Wright W.E., Shay J.W., and Taylor R.S. Telomerase activity concentrates in the mitotically active segments of human hair follicles. J. Invest. Dermatol. 108 (1997) 113-117
    • (1997) J. Invest. Dermatol. , vol.108 , pp. 113-117
    • Ramirez, R.D.1    Wright, W.E.2    Shay, J.W.3    Taylor, R.S.4
  • 12
    • 0034598919 scopus 로고    scopus 로고
    • Secondary structure of vertebrate telomerase RNA
    • Chen J.L., Blasco M.A., and Greider C.W. Secondary structure of vertebrate telomerase RNA. Cell 100 (2000) 503-514
    • (2000) Cell , vol.100 , pp. 503-514
    • Chen, J.L.1    Blasco, M.A.2    Greider, C.W.3
  • 13
    • 0037079673 scopus 로고    scopus 로고
    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
    • Chen J.L., Opperman K.K., and Greider C.W. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30 (2002) 592-597
    • (2002) Nucleic Acids Res. , vol.30 , pp. 592-597
    • Chen, J.L.1    Opperman, K.K.2    Greider, C.W.3
  • 14
    • 0037439107 scopus 로고    scopus 로고
    • Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
    • Chen J.L., and Greider C.W. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22 (2003) 304-314
    • (2003) EMBO J. , vol.22 , pp. 304-314
    • Chen, J.L.1    Greider, C.W.2
  • 15
    • 0033636897 scopus 로고    scopus 로고
    • Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    • Mitchell J.R., and Collins K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6 (2000) 361-371
    • (2000) Mol. Cell , vol.6 , pp. 361-371
    • Mitchell, J.R.1    Collins, K.2
  • 16
    • 0032803237 scopus 로고    scopus 로고
    • Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
    • Tesmer V.M., Ford L.P., Holt S.E., Frank B.C., Yi X., Aisner D.L., Ouellette M., Shay J.W., and Wright W.E. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19 (1999) 6207-6216
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6207-6216
    • Tesmer, V.M.1    Ford, L.P.2    Holt, S.E.3    Frank, B.C.4    Yi, X.5    Aisner, D.L.6    Ouellette, M.7    Shay, J.W.8    Wright, W.E.9
  • 17
    • 15444376119 scopus 로고    scopus 로고
    • The structure of an enzyme-activating fragment of human telomerase RNA
    • Leeper T.C., and Varani G. The structure of an enzyme-activating fragment of human telomerase RNA. RNA 11 (2005) 394-403
    • (2005) RNA , vol.11 , pp. 394-403
    • Leeper, T.C.1    Varani, G.2
  • 21
    • 0038701811 scopus 로고    scopus 로고
    • Telomerase inhibition as cancer therapy
    • Saretzki G. Telomerase inhibition as cancer therapy. Cancer Lett. 194 (2003) 209-219
    • (2003) Cancer Lett. , vol.194 , pp. 209-219
    • Saretzki, G.1
  • 22
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X., Mar V., Zhou W., Harrington L., and Robinson M.O. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13 (1999) 2388-2399
    • (1999) Genes Dev. , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 24
    • 0037439108 scopus 로고    scopus 로고
    • Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of its gene
    • Hao Z.M., Luo J.Y., Cheng J., Wang Q.Y., and Yang G.X. Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of its gene. World J. Gastroenterol. 9 (2003) 104-107
    • (2003) World J. Gastroenterol. , vol.9 , pp. 104-107
    • Hao, Z.M.1    Luo, J.Y.2    Cheng, J.3    Wang, Q.Y.4    Yang, G.X.5
  • 25
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase: a target for cancer therapeutics
    • Shay J.W., and Wright W.E. Telomerase: a target for cancer therapeutics. Cancer Cell 2 (2002) 257-265
    • (2002) Cancer Cell , vol.2 , pp. 257-265
    • Shay, J.W.1    Wright, W.E.2
  • 26
    • 0032578525 scopus 로고    scopus 로고
    • Inhibition of human telomerase by 2′-O-methyl-RNA
    • Pitts A.E., and Corey D.R. Inhibition of human telomerase by 2′-O-methyl-RNA. Proc. Natl. Acad. Sci. USA 95 (1998) 11549-11554
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11549-11554
    • Pitts, A.E.1    Corey, D.R.2
  • 27
    • 0035870755 scopus 로고    scopus 로고
    • Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution, and time inside cells
    • Elayadi A.N., Demieville A., Wancewicz E.V., Monia B.P., and Corey D.R. Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution, and time inside cells. Nucleic Acids Res. 29 (2001) 1683-1689
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1683-1689
    • Elayadi, A.N.1    Demieville, A.2    Wancewicz, E.V.3    Monia, B.P.4    Corey, D.R.5
  • 30
    • 0037148329 scopus 로고    scopus 로고
    • Telomerase inhibition, oligonucleotides, and clinical trials
    • Corey D.R. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene 21 (2002) 631-637
    • (2002) Oncogene , vol.21 , pp. 631-637
    • Corey, D.R.1
  • 32
    • 0033524027 scopus 로고    scopus 로고
    • Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships
    • Read M.A., Wood A.A., Harrison J.R., Gowan S.M., Kelland L.R., Dosanjh H.S., and Neidle S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships. J. Med. Chem. 42 (1999) 4538-4546
    • (1999) J. Med. Chem. , vol.42 , pp. 4538-4546
    • Read, M.A.1    Wood, A.A.2    Harrison, J.R.3    Gowan, S.M.4    Kelland, L.R.5    Dosanjh, H.S.6    Neidle, S.7
  • 35
    • 0035913742 scopus 로고    scopus 로고
    • Selective interactions of cationic porphyrins with G-quadruplex structures
    • Han H., Langley D.R., Rangan A., and Hurley L.H. Selective interactions of cationic porphyrins with G-quadruplex structures. J. Am. Chem. Soc. 123 (2001) 8902-8913
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 8902-8913
    • Han, H.1    Langley, D.R.2    Rangan, A.3    Hurley, L.H.4
  • 36
    • 0035924232 scopus 로고    scopus 로고
    • Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase
    • Shi D.F., Wheelhouse R.T., Sun D., and Hurley L.H. Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J. Med. Chem. 44 (2001) 4509-4523
    • (2001) J. Med. Chem. , vol.44 , pp. 4509-4523
    • Shi, D.F.1    Wheelhouse, R.T.2    Sun, D.3    Hurley, L.H.4
  • 37
    • 0039129145 scopus 로고    scopus 로고
    • Accelerated assembly of G-quadruplex structures by a small molecule
    • Han H., Cliff C.L., and Hurley L.H. Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry 38 (1999) 6981-6986
    • (1999) Biochemistry , vol.38 , pp. 6981-6986
    • Han, H.1    Cliff, C.L.2    Hurley, L.H.3
  • 38
    • 0035895934 scopus 로고    scopus 로고
    • Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule
    • Rangan A., Fedoroff O.Y., and Hurley L.H. Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. J. Biol. Chem. 276 (2001) 4640-4646
    • (2001) J. Biol. Chem. , vol.276 , pp. 4640-4646
    • Rangan, A.1    Fedoroff, O.Y.2    Hurley, L.H.3
  • 41
    • 0347724051 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by preventing proper assemblage
    • Keppler B.R., and Jarstfer M.B. Inhibition of telomerase activity by preventing proper assemblage. Biochemistry 43 (2004) 334-343
    • (2004) Biochemistry , vol.43 , pp. 334-343
    • Keppler, B.R.1    Jarstfer, M.B.2
  • 44
    • 0029023065 scopus 로고
    • Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity, and sensitivity
    • Wright W.E., Shay J.W., and Piatyszek M.A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity, and sensitivity. Nucleic Acids Res. 23 (1995) 3794-3795
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3794-3795
    • Wright, W.E.1    Shay, J.W.2    Piatyszek, M.A.3
  • 45
    • 0036249843 scopus 로고    scopus 로고
    • A rapid direct telomerase assay method using 96-well streptavidin plates
    • Francis R., and Friedman S.H. A rapid direct telomerase assay method using 96-well streptavidin plates. BioTechniques 32 (2002) 1154-1160
    • (2002) BioTechniques , vol.32 , pp. 1154-1160
    • Francis, R.1    Friedman, S.H.2
  • 46
    • 0242690429 scopus 로고    scopus 로고
    • An interference-free fluorescent assay of telomerase for the high-throughput analysis of inhibitors
    • Francis R., and Friedman S.H. An interference-free fluorescent assay of telomerase for the high-throughput analysis of inhibitors. Anal. Biochem. 323 (2003) 65-73
    • (2003) Anal. Biochem. , vol.323 , pp. 65-73
    • Francis, R.1    Friedman, S.H.2
  • 49
    • 0029935711 scopus 로고    scopus 로고
    • Detection of telomerase activity by combination of TRAP method and scintillation proximity assay (SPA)
    • Savoysky E., Akamatsu K., Tsuchiya M., and Yamazaki T. Detection of telomerase activity by combination of TRAP method and scintillation proximity assay (SPA). Nucleic Acids Res. 24 (1996) 1175-1176
    • (1996) Nucleic Acids Res. , vol.24 , pp. 1175-1176
    • Savoysky, E.1    Akamatsu, K.2    Tsuchiya, M.3    Yamazaki, T.4
  • 50
    • 0024969084 scopus 로고
    • Scintillation proximity assay
    • Bosworth N., and Towers P. Scintillation proximity assay. Nature 341 (1989) 167-168
    • (1989) Nature , vol.341 , pp. 167-168
    • Bosworth, N.1    Towers, P.2
  • 51
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang J.H., Chung T.D., and Oldenburg K.R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4 (1999) 67-73
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 52
    • 0033049185 scopus 로고    scopus 로고
    • Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
    • Yi X., Tesmer V.M., Savre-Train I., Shay J.W., and Wright W.E. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol. Cell. Biol. 19 (1999) 3989-3997
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3989-3997
    • Yi, X.1    Tesmer, V.M.2    Savre-Train, I.3    Shay, J.W.4    Wright, W.E.5
  • 53
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • Hamilton S.E., Simmons C.G., Kathiriya I.S., and Corey D.R. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol. 6 (1999) 343-351
    • (1999) Chem. Biol. , vol.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3    Corey, D.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.