In vivo enhancement of Herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition

International Journal of Cancer

Volumn 118, Issue 11, 2006, Pages 2907-2910

  Wahlfors, Tiina ^a   Hakkarainen, Tanja ^a   Jänne, Juhani ^a   Alhonen, Leena ^a   Wahlfors, Jarmo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Animal model; Cancer gene therapy; DFMO; Lentivirus vector; Polyamines; Suicide gene; TK GFP fusion

Indexed keywords

EFLORNITHINE; GANCICLOVIR; ORNITHINE DECARBOXYLASE INHIBITOR; POLYAMINE; PUTRESCINE; SPERMIDINE; THYMIDINE KINASE; VIRUS ENZYME;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER THERAPY; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN L9; CYTOTOXICITY; DRUG EFFECT; ENZYME INHIBITION; FEMALE; FUSION GENE; GENE THERAPY; GLIOMA CELL; HERPES SIMPLEX VIRUS; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; SUICIDE GENE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; EFLORNITHINE; FEMALE; GANCICLOVIR; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GLIOMA; MICE; MICE, NUDE; POLYAMINES; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 33646342238     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.21722     Document Type: Article

References (11)

1. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986;46:5276-81.
2. Filial C, Carrio M, Cascante A, Sangro B. Suicide gene therapy mediated by the Herpes simplex virus thymidine kinase gene/ganciclovir system: fifteen years of application. Curr Gene Ther 2003;3:13-26.
3. Seidenfeld J, Gray JW, Marton LJ. Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-α-difluoromethylornithine inhibits proliferation and the G1 to S transition. Exp Cell Res 1981;131:209-16.
4. Fredlund JO, Oredsson SM. Normal G1/S transition and prolonged S phase within one cell cycle after seeding cells in the presence of an ornithine decarboxylase inhibitor. Cell Prolif 1996;29:457-66.
5. Pasanen T, Karppinen A, Alhonen L, Janne J, Wahlfors J. Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells. Int J Cancer 2003;104:380-8.
6. Pasanen T, Hakkarainen T, Timonen P, Parkkinen J, Tenhunen A, Loimas S, Wahlfors J. TK-GFP fusion gene virus vectors as tools for studying the features of HSV-TK/ganciclovir cancer gene therapy in vivo. Int J MoL Med 2003;12:525-31.
7. Janne J, Williams-Ashman HG. On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme. J Biol Chem 1971;246:1725-32.
8. Hyvonen T, Keinanen TA, Khomutov AR, Khomutov RM, Eloranta TO. Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography. J Chromatogr 1992;574:17-21.
9. Pellinen R, Hakkaraineri T, Wahlfors T, Tulimaki K, Ketola A, Tenhunen A, Salonen T, Wahlfors J. Cancer cells as targets for lentivirus-mediated gene transfer and gene therapy. Int J Oncol 2004;25:1753-62.
10. Kallio A, Seppanen P, Alhonen-Hongisto L, Janne J. Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration. Cancer Res 1983;43:324-7.
11. Loimas S, Pasanen T, Gomes A, Bizarro S, Morgan RA, Jänne J, Wahlfors J. Viral vectors carrying a marker-suicide fusion gene (TK-GFP) as tools for TK/GCV-mediated cancer gene therapy. Gene Ther Mol Biol 2000;5:165-74. Available at www.gtmb.org/toc5.htm.