Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model

Inflammopharmacology

Volumn 14, Issue 1-2, 2006, Pages 22-27

  Patil, C S ^b   Padi, S V ^a   Singh, V P ^a   Kulkarni, S K ^a  

^a PANJAB UNIVERSITY   (India)

^b Panacea Biotec Ltd   (India)

Author keywords

Hyperalgesia; Neuropathic pain; PDE 5; Sildenafil

Indexed keywords

CYCLIC GMP; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; SODIUM CHLORIDE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HYPERALGESIA; LOCOMOTION; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SCIATIC NEUROPATHY;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CHRONIC DISEASE; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; METHYLENE BLUE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PAIN; PAIN THRESHOLD; PIPERAZINES; RATS; RATS, WISTAR; SCIATIC NEUROPATHY; SIGNAL TRANSDUCTION;

EID: 33646260922     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-006-1511-y     Document Type: Article

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