Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring

International Journal of Medical Sciences

Volumn 3, Issue 1, 2006, Pages 21-25

  Pedersen, Lars ^a,b   Skriver, Mette Vinther ^a   Nørgaard, Mette ^a   Sørensen, Henrik Toft ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Department of Clinical Epidemiology ^*  (Denmark)

Author keywords

Case control studies; Drug safety; Hypospadias; Loratadine; Pregnancy

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; ANTIHISTAMINIC AGENT; CLOMIFENE; LORATADINE;

ANAMNESIS; ARTICLE; COHORT ANALYSIS; CONCEPTION; CONTROLLED STUDY; DATA BASE; DENMARK; FIRST TRIMESTER PREGNANCY; HOSPITAL DISCHARGE; HUMAN; HYPOSPADIAS; MAJOR CLINICAL STUDY; MALE; NEWBORN; POPULATION BASED CASE CONTROL STUDY; PREGNANCY; PREGNANCY OUTCOME; PRESCRIPTION; PROGENY; PUERPERIUM;

EID: 33646243788     PISSN: 14491907     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.3.21     Document Type: Article

References (29)

1. Matlai P, Beral V. Trends in congenital malformations of external genitalis. Lancet 1985;1:108.
2. Bjerkedal T, Bakketeig LS. Surveillance of congenital malformations and other conditions of the newborn. Int J Epidemiol 1975;4:31-6.
3. Kallen B, Winberg J. An epidemiologic study of hypospadias in Sweden. Acta Paediatr Scand 1982;293:1-21.
4. Silver RI, Rodriguez R, Chang TS, Gearhart JP. In vitro fertilization is associated with an increased risk of hypospadias. J Urol 1999;161:1954-7.
5. Czeizel A. Increasing trends in congenital malformations of male external genitalia. Lancet 1985;1:462-3.
6. Paulozzi LJ, Erickson D, Jackson RJ. Hypospadias in trends in two US surveillance systems. Pediatrics 1997;100:831-4.
7. Gallentine ML, Morey AF, Thompson I. Hypospadias: a contemporary epidemiologic assessment. Urology 2001;57:788-90.
8. Åberg A, Westbom L, Källén B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Develop 2001; 61:85-95.
9. Fredell L, Kockum I, Hansson E, Holmner S, Lundquist L, Läckgren G, et al. Heredity of hypospadias and the significance of low birth weight. J Urol 2002; 167:1423-7.
10. Hussain N, Chaghtai A, Herndon CD, Herson VC, Rosenkrantz TS, McKenna PH. Hypospadias and early gestation growth restriction in infants. Pediatrics 2002;109: 473-8.
11. Wu WH, Chuang JH, Ting YC, Lee SY, Hsieh CS. Developmental anomalies and disabilities associated with hypospadias. J Urol 2002;168:229-32.
12. Silver RI. What is the etiology of hypospadias? A review of recent research. Del Med J 2000;72:343-7.
13. Fredell L, Lichtenstein P, Pedersen NL, Svensson J, Nordenskjold A. Hypospadias is related to birth weight in discordant monozygotic twins. J Urol 1998;160:2197-9.
14. Weidner IS, Møller H, Jensen TK, Skakkebæk NE. Risk factors for cryptorchidism and hypospadias. J Urol 1999;161:1606-9.
15. Chambers EL, Malone PS. The incidence of hypospadias in two English cities: a case-control comparison of possible causal factors. BJU International 1999;84:95-8.
16. Wennerholm UB, Bergh C, Hamberger L, Lundin K, Nilsson L, Wikland M, et al. Incidence of congenital malformations in children born after ICSI. Hum Reprod 2000; 15:944-8.
17. Klip H, Verloop J, van Gool JD, Koster ME, Burger CW, van Leeuwen FE; OMEGA Project Group.. Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study. Lancet 2002;359:1102-7.
18. Dansk Lægemiddel information. Lægemiddelkataloget 2004. Copenhagen, Denmark: Dansk Lægemiddel Information. 2004.
19. Källén B, Olausson PO. Monitoring of maternal drug use and infant congenital malformations. Does loratadine cause hypospadias? Int J Risk Safety Med 2002; 14:115-9.
20. Diav-Citrin O, Shechtman S, Aharonovich A, Moerman L, Arnon J, Wajnberg R, et al. Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study. J Allergy Clin Immunol 2003;111:1239-43.
21. Moretti ME, Caprara D, Coutinho CJ, Bar-Oz B, Berkovitch M, Addis A, Jovanovski E, Schuler-Faccini L, Koren G. Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study. J Allergy Clin Immunol 2003;111:479-83.
22. Centers for Disease Control and Prevention (CDC). Evaluation of an association between loratadine and hypospadias - United States, 1997-2001. MMWR Morb Mortal Wkly Rep. 2004;53:219-21.
23. Andersen TF, Madsen M, Jørgensen J, Mellemkjær L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999;46:263-8.
24. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull 1998; 45:320-3.
25. Kristensen J, Langhoff-Roos J, Skovgaard LT, Kristensen FB. Validation of the Danish Birth Registration. J Clin Epidemiol 1996;49:893-7.
26. Gaist D, Sørensen HT, Hallas J. The Danish prescription registries. Dan Med Bull 1997;44:445-8.
27. Olsen J, Czeizel A, Sørensen HT, Nielsen GL, de Jong van den Berg LT, Irgens LM, et al. How do we best detect toxic effects of drugs taken during pregnancy? A EuroMap paper. Drug Saf 2002;25:21-32.
28. Olsen JH, Sørensen HT, Friis S, McLaughlin JK, Steffensen FH, Nielsen GL, et al. Cancer risk in users of calcium channel blockers. Hypertension 1997;29:1091-4.
29. Mitchel AA. Special considerations in studies of drug-induced birth defects. In: Strom BL, Ed. Pharmacoepidemiology. Chichester: John Wiley & Sons. 1994: 595-608.