Effects of daunorubicin, mitomycin C, azathioprine and cyclosporin A on human retinal pigmented epithelial, corneal endothelial and conjunctival cell lines

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 244, Issue 3, 2006, Pages 382-389

  Garweg, Justus G ^a   Wegmann Burns, Maria ^a,b   Goldblum, David ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Hopital Cantonal de Fribourg   (Switzerland)

Author keywords

Azathioprine; Calcein uptake; Cell proliferation; Cell viability assay; Chang cells; Cyclosporin A; Daunorubicin; Glaucoma; Human corneal endothelial cells; Mitomycin; PVR; Retinal pigmented epithelial cells; Toxicity; Wound healing

Indexed keywords

AZATHIOPRINE; CALCEIN; CYCLOSPORIN A; DAUNORUBICIN; IMMUNOSUPPRESSIVE AGENT; MITOMYCIN C; PROPIDIUM IODIDE;

ACUTE TOXICITY; ARTICLE; CELL CULTURE; CELL DENSITY; CELL LINE; CELL LOSS; CELL PROLIFERATION; CELL VIABILITY; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DRUG EFFICACY; DRUG EXPOSURE; DRUG MONITORING; GLAUCOMA; HUMAN; HUMAN CELL; IMMUNOMODULATION; INHIBITION KINETICS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCAR FORMATION; VITREORETINOPATHY;

ANTIMETABOLITES; AZATHIOPRINE; CELL COUNT; CELL LINE; CELL PROLIFERATION; CONJUNCTIVA; CYCLOSPORINE; DAUNORUBICIN; ENDOTHELIUM, CORNEAL; EPITHELIAL CELLS; FLUORESCEINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MITOMYCIN; PIGMENT EPITHELIUM OF EYE; PROPIDIUM;

EID: 33646242034     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-005-0017-4     Document Type: Article

References (32)

1. Ben-Simon GJ, Glovinsky Y (2003) Needle revision of failed filtering blebs augmented with subconjunctival injection of mitomycin C. Ophthalmic Surg Lasers 34:94-99
2. Berger AS, Cheng CK, Pearson A, Ashton P, Crooks PA, Cynkowski T, Cynkowska G, Jaffe GJ (1996) Intravitreal sustained release corticosteroid-5-fluorouracil conjugate in the treatment of experimental proliferative vitreoretinopathy. Investig Ophthalmol Vis Sci 37:2318-2325
3. Bindlish R, Condon GP, Schlosser JD, D'Antonio J, Lauer KB, Lehrer R (2002) Efficacy and safety of mitomycin-C in primary trabeculectomy. Ophthalmology 109:1336-1341
4. Blumenkranz M, Hernandez E, Ophir A, Norton EWD (1984) 5-Fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology 91:122-129
5. Daniels JT, Occleston NL, Crowston JG, Khaw PT (1999) Effects of antimetabolite induced cellular growth arrest on fibroblast-fibroblast interactions. Exp Eye Res 69:117-127
6. Hui YN, Liang HC, Cai AS, Kirchhof B, Heidemann K (1993) Corticosteroids and daunomycin in the prevention of experimental proliferative vitreoretinopathy induced by macrophages. Graefe Arch Clin Exp Ophthalmol 231:109-114
7. Khaw PT, Sherwood MB, MacKay SL, Rossi MJ, Schultz G (1992) Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol 110:1150-1154
8. Khaw PT, Doyle JW, Sherwood MB, Grierson I, Schultz G, McGorray S (1993) Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. Arch Ophthalmol 111:263-267
9. Khawly JA, Saloupis P, Hatchell DL, Machemer R (1991) Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy. Graefe Arch Clin Exp Ophthalmol 229:464-467
10. Leonardi A, DeFranchis G, Fregona IA, Violato D, Plebani M, Secchi AG (2001) Effects of cyclosporin A on human conjunctival fibroblasts. Arch Ophthalmol 10:1512-1517
11. Machemer R, Sugita G, Tano Y (1979) Treatment of intraocular proliferations with intravitreal steroids. Trans Am Ophthalmol Soc 77:171-180
12. Mandal AK, Bagga H, Nutheti R, Gothwal VK, Nanda AK (2003) Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery. Eye 17:53-62
13. Mietz H, Jacobi PC, Krieglstein GK (2002) Intraoperative episcleral versus postoperative topical application of mitomycin C for trabeculectomies. Ophthalmology 109:1343-1349
14. Neri S, Mariani E, Meneghetti A, Cattini L, Facchini A (2001) Calcein-acetyoxymethyl cytotoxicity assay: Standardization of a method allowing additional analyses on recovered effector cells and supernatants. Clin Diagn Lab Immunol 8:1131-1135
15. Nuzzi R, Cerruti A, Finazzo C (1998) Cyclosporine C: A study of wound-healing modulation after trabeculectomy in rabbit. Acta Ophthalmol Scand Suppl 227:48-49
16. Occlston NL, Daniels JT, Tarnuzzer RW, Sethi KK, Alexander RA, Bhattacharya SS, Schultz GS, Khaw PT (1997) Single exposures to antiproliferatives. Investig Ophthalmol Vis Sci 38:1998-2007
17. Rubinfeld RS, Pfister RR, Stein RM (1992) Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology 99:1647-1654
18. Salah-Eldin M, Peyman GA, El-Aswad M, Bandok G, Bahgat MM, Niesman MR (1994) Evaluation of toxicity and efficacy of antineoplastic agents in the prevention of PVR. Int Ophthalmol 18:53-60
19. Schipper I, Suppelt C, Gebbers JO (1997) Mitomycin C reduces scar formation after excimer laser (193 nm) photorefractive keratectomy in rabbits. Eye 11:649-655
20. Shin DH, Kim YY, Ginda SY, Kim PH, Eliassi-Rad B, Khatana AK, Keole NS (2001) Risk factors for failure of 5-fluorouracil needling revision for failed conjunctival filtration blebs. Am J Ophthalmol 132:875-880
21. Shin DH, Iskander NG, Ahee JA, Singal IP, Kim C, Hughes GA, Eliassi-Rad B, Kim YY (2002) Long-term filtration and visual field outcomes after primary glaucoma triple procedure with and without mitomycin-C. Ophthalmology 109:1607-1611
22. Suñer IJ, Greenfield DS, Miller MP, Nicolela MT, Palmberg PF (1997) Hypotony maculopathy after filtering surgery with mitomycin C. Ophthalmology 104:207-214
23. Talamo JH, Gollamundi S, Green WR (1991) Modulation of corneal wound healing after excimer laser keratomileusis using topical mitomycin C and steroids. Arch Ophthalmol 109:1141-1146
24. Tano Y, Sugita G, Abrams G, Machemer R (1989) Inhibition of intraocular proliferation with intravitreal corticosteroids. Am J Ophthalmol 89:131-136
25. The Fluorouracil Filtering Surgery Study Group (1989) Fluorouracil filtering surgery study one-year follow-up. Am J Ophthalmol 108:625-635
26. Tung IC, Wu WC, Kao YH, Chang YC, Chung CH, Hu DN (2001) The effect of combined 5-fluorouracil and dexamethasone on cultured human retinal pigment epithelial cells. Kaohsiung J Med Sci 17:524-529
27. Turaçli E, Gündüz K, Aktan G, Tamer C (1996) A comparative clinical trial of mitomycin C and cyclosporin A in trabeculectomy. Eur J Ophthalmol 6:398-401
28. Ventura AC, Böhnke M (1999) Toxicity of pentoxifylline on monolayers of highly proliferative cells of epithelial origin. J Ocul Pharmacol Ther 15:525-535
29. Wiedemann P, Lemmen K, Schmiedl R, Heimann K (1987) Intraocular daunorubicin for the treatment and prophylaxis of traumatic proliferative vitreoretinopathy. Am J Ophthalmol 104:10-14
30. Wiedemann P, Hilgers RD, Bauer P, Heimann K (1998) Adjunctive daunorubicin in the treatment of proliferative vitreoretinopathy: results of a multicenter clinical trial. Am J Ophthalmol 126:550-559
31. Wu WC, Kao YH, Hu DN (2002) A comparative study of effects of antiproliferative drugs on human retinal pigment epithelial cells in vitro. J Ocul Pharmacol Ther 18:251-264
32. Yang A, Cardona DL, Barile FA (2002) In vitro cytotoxicity testing with fluorescence-based assays in cultured human lung and dermal cells. Cell Biol Toxicol 18:97-108