Detection of functional differences between different platelet membrane glycoprotein Ibα variable number tandem repeat and Kozak genotypes as shown by the PFA-100 system

Heart

Volumn 92, Issue 5, 2006, Pages 676-678

  Douglas, H ^a   Davies, G J ^a   Michaelides, K ^b   Gorog, D A ^a   Timlin, H ^a   Ahmed, N ^a   Tuddenham, E G D ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLYCOPROTEIN IB ALPHA; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; VARIABLE NUMBER OF TANDEM REPEAT;

ASPIRIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; TANDEM REPEAT SEQUENCES;

EID: 33646235405     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2004.058545     Document Type: Article

References (7)

1. Andrew RK, Lopez JA, Berndt MC. Molecular mechanism of platelet adhesion and activation. Int J Biochem Cell Biol 1997;29:91-105.
2. Afshar-Kharghan V, Bray PF. Platelet polymorphisms. In: Michelson AD, eds. Platelets. London: Academic Press, 2002:157-80.
3. Douglas H, Michaelides K, Gorog DA, et al. Platelet membrane glycoprotein Ibα gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis. Heart 2002;87:70-4.
4. Kundu SK, Heilman EJ, Sio R, et al. Characterisation of an in vitro platelet function analyser PFA-100. Clin Appl Thromb Haemost 1996;2:241-9.
5. Ambrose JA, Fuster V. The risk of coronary occlusion is not proportional to the prior severity of coronary stenoses. Heart 1998;79:3-4.
6. Afshar-Kargan V, Matijevic-Aleksic N, Ahn C, et al. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and the risk of coronary heart disease. Blood 2004;103:963-5.
7. Gonzales-Conejero R, Lozano ML, Rivera J, et al. Polymorphisms of platelet membrane glycoprotein Ibα associated with arterial thrombotic disease. Blood 1998;92:2771-2.