Comparative study of the fluid dynamics of bottom spray fluid bed coaters

AAPS PharmSciTech

Volumn 7, Issue 2, 2006, Pages

  Chan, L W ^a   Tang, Elaine S K ^a   Heng, Paul W S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Coating; Flow; Fluid bed coaters; Pellets

Indexed keywords

DRUG;

AEROSOL; AIRFLOW; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG COATING; DRUG PELLET; FLOW RATE; FLUIDIZATION; NEBULIZATION; PHOTOGRAPHY;

EID: 33646205892     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070237     Document Type: Article

References (18)

1. Christensen FN, Bertelson P. Qualitative description of the Wurster-based fluid-bed coating process. Drug Dev Ind Pharm. 1997;23: 451-463.
2. Porter SC, Bruno CH. Coating of pharmaceutical solid-dosage forms. In: Lieberman HA, Lachman L, Schwartz JB, eds. Pharmaceutical Dosage Forms, Tablets. New York, NY: Marcel Dekker; 1990:77-159.
3. Cole GC. Introduction and overview of pharmaceutical coating. In: Cole GC, ed. Pharmaceutical Coating Technology. London, UK: Taylor & Francis; 1995:1-5.
4. Horvath E, Ormos Z. Film coating of dragee seeds by fluidized bed spraying methods. Acta Pharm Tech. 1989;35:90-96.
5. Wurster DE, inventor. Method of applying coating onto edible tablets or the like. US patent 2 648 609. 1953.
6. Jono K, Ichikawa H, Miyamoto M, Fukumori Y. A review of particulate design for pharmaceutical powders and their production by spouted bed coating. Powder Tech. 2000;113:269-277.
7. Walter K, inventor. Apparatus for coating solid particles. US patent 5 718 764. 1998.
8. Sudsakorn K, Turton R. Non-uniformity of particle coating on a size distribution of particles in a fluidized bed coater. Powder Tech. 2000; 110:37-43.
9. Shelukar S, Ho J, Zega J, et al. Identification and characterization of factors controlling tablet coating uniformity in a Wurster coating process. Powder Tech. 2000;110:29-36.
10. Stein M, Ding YL, Seville JPK, Parker DJ. Solids motion in bubbling gas fluidized beds. Chem Eng Sci. 2000;55:5291-5300.
11. Fitzpatrick S, Ding Y, Seiler C, et al. Positron emission particle tracking studies of a Wurster process for coating applications. Pharm Tech. 2003;27:70-78.
12. Cassanello M, Larachi F, Legros R, Chaouki J. Solids dynamics from experimental trajectory time-series of a single particle motion in gas-spouted beds. Chem Eng Sci. 1999;54:2545-2554.
13. Xu M, Turton R. A new data processing technique for noisy signals: application to measuring particle circulation times in a draft tube equipped fluidized bed. Powder Tech. 1997;92:111-117.
14. San Jose MJ, Olazar M, Alvarez S, Izquierdo MA, Bilbao J. Solid cross-flow into the spout and particle trajectories in conical spouted beds. Chem Eng Sci. 1998;53:3561-3570.
15. USP-NF. Physical tests, bulk density and tapped density. In: US Pharmacopeia-National Formulary. First Annual Asian Edition. 2002;616:1981-1982.
16. Wells J. Pharmaceutical preformulation. In: Aulton ME, ed. Pharmaceutics: The Science of Dosage Form Design. New York, NY: Churchill Livingstone; 2002:113-138.
17. Deasy PB. Air Suspension Coating. In: Deasy PB, ed. Microencapsulation and Related Drug Processes. New York, NY: Marcel Dekker; 1984:161-180.
18. Porter SC, Ghebre-Sellassie I. Key factors in the development of modified-release pellets. In: Ghebre-Sellasie I, ed. Multiparticulate Oral Drug Delivery. New York, NY: Marcel Dekker; 1990: 217-284.