Discovery of a new chemical lead for a matrix metalloproteinase inhibitor

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 4241-4252

  Ikura, Masahiro ^a   Nakatani, Shingo ^a   Yamamoto, Shingo ^a   Habashita, Hiromu ^a   Sugiura, Tsuneyuki ^a   Takahashi, Kanji ^a   Ogawa, Koji ^a   Ohno, Hiroyuki ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Matrix metalloproteinase inhibitor

Indexed keywords

4 (1 BENZOFURAN 2 YL) N [4 (HYDROXYAMINO) 4 OXOBUTYL]BENZAMIDE; 4 [2 (4 CHLOROPHENYL)VINYL] N [4 (HYDROXYAMINO) 4 OXOBUTYL]BENZAMIDE; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; N [4 (HYDROXYAMINO) 4 OXOBUTYL] 4 METHYLBENZAMIDE; N BENZOYL GAMMA AMINOBUTYRIC HYDROXAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; INHIBITION KINETICS; PHARMACOPHORE; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MATRIX METALLOPROTEINASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646196608     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.059     Document Type: Article

References (8)

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