Searching for the molecular arrangement of transmembrane ceramide channels

Biophysical Journal

Volumn 90, Issue 7, 2006, Pages 2414-2426

  Anishkin, A ^a   Sukharev, S ^a   Colombini, M ^a  

^a Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; HYDROCARBON; PHOSPHOLIPID DERIVATIVE;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; SIMULATION;

EID: 33646196189     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.071977     Document Type: Article

References (17)

1. 16-ceramide form large stable channels. Implications for apoptosis. J. Biol. Chem. 275:38640-38644.
2. Siskind, L. J., R. N. Kolesnick, and M. Colombini. 2002. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J. Biol. Chem. 277:26796-26803.
3. 2-ceramide channels. Biophys. J. 85:1560-1575.
4. Montes, L. R., M. B. Ruiz-Arguello, F. M. Goni, and A. Alonso. 2002. Membrane restructuring via ceramide results in enhanced solute efflux. J. Biol. Chem. 277:11788-11794.
5. Chiu, S. W., S. Vasudevan, E. Jakobsson, R. J. Mashl, and H. L. Scott. 2003. Structure of sphingomyelin bilayers: a simulation study. Biophys. J. 85:3624-3635.
6. Niemela, P., M. T. Hyvonen, and I. Vattulainen. 2004. Structure and dynamics of sphingomyelin bilayer: insight gained through systematic comparison to phosphatidylcholine. Biophys. J. 87:2976-2989.
7. Tieleman, D. P., H. Leontiadou, A. E. Mark, and S. J. Marrink. 2003. Simulation of pore formation in lipid bilayers by mechanical stress and electric fields. J. Am. Chem. Soc. 125:6382-6383.
8. Tieleman, D. P. 2004. The molecular basis of electroporation. BMC Biochem. 5:10.
9. Gullingsrud, J., and K. Schulten. 2004. Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys. J. 86:3496-3509.
10. Humphrey, W., A. Dalke, and K. Schulten. 1996. VMD: visual molecular dynamics. J. Mol. Graph. 14:33-38.
11. Kale, L., R. Skeel, M. Bhandarkar, R. Brunner, A. Gursoy, N. Krawetz, J. Phillips, A. Shinozaki, K. Varadarajan, and K. Schulten. 1999. NAMD2: greater scalability for parallel molecular dynamics. J. Comput. Phys. 151:283-312.
12. MacKerell, A. D., D. Bashford, M. Bellott, R. L. Dunbrack, J. D. Evanseck, M. J. Field, S. Fischer, J. Gao, H. Guo, S. Ha, D. Joseph-McCarthy, L. Kuchnir, K. Kuczera, F. T. K. Lau, C. Mattos, S. Michnick, T. Ngo, D. T. Nguyen, B. Prodhom, W. E. Reiher, B. Roux, M. Schlenkrich, J. C. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiorkiewicz-Kuczera, D. Yin, and M. Karplus. 1998. All-atom empirical potential for molecular modeling and dynamics studies of proteins. J. Phys. Chem. B. 102:3586-3616.
13. Jorgensen, W. L., J. Chandrasekhar, J. D. Madura, R. W. Impey, and M. L. Klein. 1983. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 79:926-935.
14. Hall, J. E. 1975. Access resistance of a small circular hole. J. Gen. Physiol. 66:531-532.
15. Marrink, S. J., E. Lindahl, O. Edholm, and A. E. Mark. 2001. Simulation of the spontaneous aggregation of phospholipids into bilayers. J. Am. Chem. Soc. 123:8638-8639.
16. 2H-NMR dynamical parameters on water environment depending on their lipid composition. Mol. Membr. Biol. 20:319-327.
17. 2H NMR study of the influence of carbohydrate headgroup structure on ceramide acyl chain behavior in glycolipid-phospholipid bilayers. Biochemistry. 30:4503-4509.