Inosine infusion prevents mortality in endotoxic shock

Journal of Trauma - Injury, Infection and Critical Care

Volumn 59, Issue 6, 2005, Pages 1432-1435

  Darlington, Daniel N ^a   Gann, Donald S ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Endotoxin; Inosine; Lipopolysaccharide; Na K ATPase; Resuscitation; Sepsis; Shock

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); INOSINE; LIPOPOLYSACCHARIDE; NITROBENZYLTHIOINOSINE; POTASSIUM ION; SODIUM ION; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4;

ANIMAL MODEL; ARTICLE; CELL SWELLING; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; SEPTIC SHOCK; SURVIVAL; ANIMAL; BLOOD PRESSURE; DISEASE MODEL; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HEART RATE; INFUSIONS, INTRAVENOUS; INOSINE; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RESUSCITATION; SHOCK, SEPTIC; SURVIVAL ANALYSIS;

EID: 33646183025     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ta.0000196007.34175.46     Document Type: Article

References (26)

1. Illner HP, Shires GT. Membrane defect and energy status of rabbit skeletal muscle cells in sepsis and septic shock. Arch Surg. 1981;116:1302-1305.
2. Shires GT, Cunningham JN, Backer CR, et al. Alterations in cellular membrane function during hemorrhagic shock in primates. Ann Surg. 1972;176:288-295.
3. Cunningham JN Jr, Wagner Y, Shires GT. Changes in intracellular sodium content of red blood cells in hemorrhagic shock. Surg Forum. 1970;21:38-40.
4. Campion DS, Lynch LJ, Rector FC Jr, et al. Effect of hemorrhagic shock on transmembrane potential. Surgery. 1969;66:1051-1059.
5. Darlington DN, Chew G, Ha T, et al. Corticosterone, but not glucose, treatment enables fasted adrenalectomized rats to survive moderate hemorrhage. Endocrinology. 1990;127:766-772.
6. Illner H, Shires GT. Changes in sodium, potassium, and adenosine triphosphate contents of red blood cells in sepsis and septic shock. Circ Shock. 1982;9:259-267.
7. Peitzman AB, Shires GT 3rd, Illner H, et al. Effect of intravenous ATP-MgCl2 on cellular function in liver and muscular in hemorrhagic shock. Curr Surg. 1981;38:300-304.
8. Gallagher JF, Shires GT. Correlation of transmembrane potential difference with high-energy phosphate levels in hemorrhagic shock. Surg Forum. 1977;28:19-21.
9. Shires GT 3rd, Peitzman AB, Illner H, Shires GT. Changes in red blood cell transmembrane potential, electrolytes, and energy content in septic shock. J Trauma. 1983;23:769-774.
10. Boulanger BR, Evans JA, Lilly MP, et al. A circulating protein that depolarizes cells increases after hemorrhage in dogs. J Trauma. 1993;34:591-598.
11. Borchelt BD, Wright PA, Evans JA, et al. Cell swelling and depolarization in hemorrhagic shock. J Trauma. 1995;39:187-192.
12. Eastridge BJ, Darlington DN, Evans JA, et al. A circulating shock protein depolarizes cells in hemorrhage and sepsis. Ann Surg. 1994;219:298-305.
13. Evans JA, Darlington DN, Gann DS. A circulating factor(s) mediates cell depolarization in hemorrhagic shock. Ann Surg. 1991;213:549-556.
14. Kowluru R, Bitensky MW, Kowluru A, et al. Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy. Proc Natl Acad Sci U S A. 1989;86:3327-3331.
15. Trunkey DD, Illner H, Wagner IY, et al. The effect of septic shock on skeletal muscle action potentials in the primate. Surgery. 1979;85:638-643.
16. Darlington DN, Gann DS. Purine nucleosides stimulate Na/K ATPase, and prolong survival in hemorrhagic shock. J Trauma. 2005;58:1055-1060.
17. Darlington DN, Gann DS. Adenosine stimulates Na/K ATPase, and prolongs survival in hemorrhagic shock. J. Trauma. 2005;58:1-6.
18. Abdel-Zaher AO, Abdel-Aal RA, Aly SA, et al. Adenosine for reversal of hemorrhagic shock in rabbits. Jpn J Pharmacol. 1996;72:247-254.
19. Griffith DA, Jarvis SM. Nucleoside and nucleobase transport systems of mammalian cells. Biochim Biophys Acta. 1996;1286:153-181.
20. Baldwin SA, Beal PR, Yao SY, et al. The equilibrative nucleoside transporter family, SLC29. Pflugers Arch. 2004;447:735-743.
21. Koc B, Erten V, Yilmaz MI, et al. The relationship between red blood cell Na/K-ATPase activities and diabetic complications in patients with type 2 diabetes mellitus. Endocrine. 2003;21:273-278.
22. Jones RO, Carlson DE, Gann DS. A circulating shock protein that depolarizes cells in vitro depresses myocardial contractility and rate in isolated rat hearts. J Trauma. 1994;37:752-758.
23. Blake P, Hasegawa Y, Khosla MC, et al. Isolation of "myocardial depressant factor(s)" from the ultrafiltrate of heart failure patients with acute renal failure. Asaio J. 1996;42:M911-M915.
24. Hasko G, Kuhel DG, Nemeth ZH, et al. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 2000;164:1013-1019.
25. Liaudet L, Mabley JG, Soriano FG, et al. Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Am J Respir Crit Care Med. 2001;164:1213-1220.
26. Remick DG, Newcomb DE, Bolgos GL, et al. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock. 2000;13:110-116.