Effect of L-NAME/L-Arginine microinjection into nucleus accumbens shell on morphine withdrawal signs in male rats

International Journal of Pharmacology

Volumn 2, Issue 2, 2006, Pages 171-176

  Sepehri, Gholamreza ^a   Sheibani, Vahid ^a   Baghaiee, Fariba ^a   Farazifard, Rasoul ^a  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

L arginine; L NAME; Morphine dependency; Morphine withdrawal; Nitric oxide; Nucleus accumbens

Indexed keywords

ARGININE; MORPHINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANALYSIS OF VARIANCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG WITHDRAWAL; JUMPING; MALE; MICROINJECTION; MORPHINE ADDICTION; NONHUMAN; NUCLEUS ACCUMBENS; RAT; RAT STRAIN; REARING; SINGLE DRUG DOSE; STEREOTAXIS; SYMPTOMATOLOGY; WEIGHT REDUCTION; WITHDRAWAL SYNDROME;

EID: 33646182198     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.171.176     Document Type: Article

References (29)

1. Adams, M.L., J.M. Kalicki, E.R. Meyer and T.J. Cicero, 1993. Inhibition of the morphine withdrawal syndrome by a nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester. Life Sci., 52: 245-249.
2. Abekawa, T., 1997. Experimental study of methamphetamine psychosis-role of glutamate and nitric oxide in methamphetamine-induced dopaminergic and serotonergic neurotoxicity in the rat brain. Hokkaido. Igaku. Zasshi., 72: 113-126.
3. Afanas'ev, I., B. Ferger and K. Kuschinsky, 2000. The associative type of sensitization to d-amphetamine is expressed as an NO-dependent dramatic increase in extracellular dopamine in the nucleus accumbens. Naunyn. Schmiedebergs. Arch. Pharmacol., 362: 232-237.
4. Cervo, L. and R. Samanin, 1995. Effects of dopaminergic and glutamatergic receptor antagonists on the acquisition and expression of cocaine conditioning place preference. Brain Res., 673: 242-250
5. Dambisya, Y.M. and T.L. Lee, 1996. Role of nitric oxide in the induction and expression of morphine tolerance and dependence in mice. Br. J. Pharmacol., 117: 914-918.
6. Dehpour, A.R., S.S. Sadr, M. Nouroddini, F. Shadan, A. Nourozi, M. Farahani and M. Sahebgharani, 2000. Comparison of simultaneous administration of lithium with L-NAME or L-arginine on morphine withdrawal syndrome in mice. Hum. Psychopharmacol., 15: 87-93
7. Gracy, K.N. and V.M. Pickel, 1997. Ultrastructural localization and comparative distribution of nitric oxide syndiase and N-methyl-D-aspartate receptors in the shell of the rat nucleus accumbens. Brain Res., 747: 259-272.
8. Gholami, A., A. Haeri-Rohani, H. Sahraie and M.R. Zarrindast, 2002. Nitric oxide mediation of morphine-induced place preference in the nucleus accumbens of rat. Eur. J. Pharmacol., 449: 269-277.
9. Gerdeman, G.L., J.G. Partridge, C.R. Lupica and D.M. Lovinger, 2003. It could be habit forming: Drugs of abuse and striatal synaptic plasticity. Trends. Neurosci., 26:184-192.
10. Gabra, B.H., E.A. Afify, T.T. Daabees and M.S. Abou Zeit-Har, 2005. The role of the NO/NMDA pathways in the development of morphine withdrawal induced by naloxone in vitro. Pharmacol. Res., 51: 319-327.
11. Higgins, G.A., P. Nguyen and E.M. Sellers, 1992. The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawal. Life Sci., 50: 167-172.
12. Harris, G.C. and G. Aston-Jones, 1994. Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome. Nature, 371: 155-157.
13. Herman, B.H., F. Vocci and P. Bridge, 1995. The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiate addiction. Neuropsychopharmacology, 13: 269-293.
14. Hall, S., B. Milne and K. Jhamandas, 1996. Nitric oxide synthase inhibitors attenuate acute and chronic morphine withdrawal response in the rat locus coeruleus: an in vivo voltammetric study. Brain Res., 739: 182-191.
15. Homayoun, H., S. Khavandgar, S.E. Mehr, K. Namiranian and A.R. Dehpour, 2003. The effects of FK506 on the development and expression of morphine tolerance and dependence in mice. Behav. Pharmacol.,14: 121-127.
16. Koyuncuoglu, H., Y. Dizdar, F. Aricioglu and U. Sayin, 1992. Effects of MK 801 on morphine physical dependence: attenuation and intensification. Pharmacol. Biochem. Behav., 43: 487-490.
17. Kimes, A.S., D.B. Vaupel and E.D. London, 1993. Attenuation of some signs of opioid withdrawal by inhibitors of nitric oxide synthase. Psychopharmacology (Berl)., 112: 521-524
18. Majeed, N.H., B. Przewlocka, H. Machelska and R. Przewlocki, 1994. Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice. Neuropharmacology, 33: 189-192.
19. Ozek, M., Y. Uresin and M. Gungor, 2003. Comparison of the effects of specific and nonspecific inhibition of nitric oxide syntbase on morphine analgesia, tolerance and dependence in mice. Life Sci., 72: 1943-1951.
20. Paxinos, G. and C. Watson, 1986. The Rat Brain in Stereotaxic Coordinates. 2nd Edn., New York: Academic Press, USA.
21. Pineda, J., M. Torrecilla, R. Martin-Ruiz and L. Ugedo, 1998. Attenuation of withdrawal-induced hyperactivity of locus coeruleus neurones by inhibitors of nitric oxide synthase in morphine-dependent rats. Neuropharmacology, 37: 759-767.
22. Sahraei, H., G. Poorheidari, M. Foadaddini, A. Khoshbaten, A. Asgari, A. Noroozzadeh, H. Ghoshooni, S.H. Firoozabadi and M.R. Zarrindast, 2004. Effects of nitric oxide on morphine self-administration in rat. Pharmacol. Biochem. Behav., 77: 111-116.
23. Sepulveda, J., P. Oliva and E. Contreras, 2004. Neurochemical changes of the extracellular concentrations of glutamate and aspartate in the nucleus accumbens of rats after chronic administration of morphine. Eur. J. Pharmacol., 483: 249-258.
24. Salamone, J.D., M. Correa, S.M. Mingote and S.M. Weber, 2005. Beyond the reward hypothesis: Alternative functions of nucleus accumbens dopamine. Curr. Opin. Pharmacol, 5: 34-41.
25. Trujillo, K.A. and H. Akil, 1991. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science, 251: 85-87.
26. Tzschentke, T.M. and W.J. Schmidt, 1997. Interactions of MK-801 and GYKI 52466 with morphine and amphetamine in place preference conditioning and behavioural sensitization. Behav. Brain. Res., 84: 99-107.
27. Tayfun Uzbay, I. and M.W. Oglesby, 2001. Nitric oxide and substance dependence. Neurosci. Biobehav. Rev., 25: 43-52.
28. Wang, H.L., Y. Zhao, X.H. Xiang, H.S. Wang and W.R. Wu, 2004. Blockade of ionotropic glutamatergic transmission in the ventral tegmental area attenuates the physical signs of morphine withdrawal in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry, 28: 1079-1087.
29. Zarrindast, M.R., H. Homayoun, S. Khavandgar, M. Fayaz-Dastgerdi and M. Fayaz-Dastgerdi, 2002. The effects of simultaneous administration of alpha (2)-adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice. Behav. Pharmacol., 13: 117-125.