Peripheral opioid regulation of nociceptors. Focus on "morphine directly inhibits nociceptors in inflamed skin"

Journal of Neurophysiology

Volumn 95, Issue 4, 2006, Pages 2031-

  Hargreaves, Kenneth M ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NALOXONE; OPIATE RECEPTOR;

ANALGESIA; DRUG EFFECT; EDITORIAL; IN VITRO STUDY; NOCICEPTIVE RECEPTOR; PRIORITY JOURNAL; SKIN INFLAMMATION;

ANIMALS; DERMATITIS; MALE; MORPHINE; NARCOTICS; NOCICEPTORS; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; SIGNAL TRANSDUCTION; SKIN;

EID: 33646180996     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00031.2006     Document Type: Editorial

References (7)

1. Dionne RA, Lepinski AM, Gordon SM, Jaber L, Brahim JS, and Hargreaves KM. Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation. Clin Pharmacol Ther 70: 66-73, 2001.
2. Gupta A, Bodin L, Holmstrom B, and Berggren L. A systematic review of the peripheral analgesic effects of intraarticular morphine. Anesth Analg 93: 761-770, 2001.
3. Joris JL, Dubner R, and Hargreaves KM. Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation? Anesth Analg 66: 1277-1281, 1987.
4. Patwardhan AM, Berg KA, Akopain AN, Jeske NA, Gamper N, Clarke WP, and Hargreaves KM. Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. J Neurosci 25: 8825-8832, 2005.
5. Stein C, Millan MJ, Shippenberg TS, Peter K, and Herz A. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J Pharmacol Exp Ther 248: 1269-1275, 1989.
6. Stein C, Schafer M, and Machelska H. Attacking pain at its source: new perspectives on opioids. Nat Med 9: 1003-1008, 2003.
7. Wenk HN, Brederson JD, and Honda CN. Morphine directly inhibits nociceptors in inflamed skin. J Neurophysiol 95: 2083-2097, 2006.