Clinical utility of hyperglycosylated hCG in serum taken before hydatidiform mole evacuation to predict persistent trophoblastic disease

International Journal of Biological Markers

Volumn 21, Issue 1, 2006, Pages 45-49

  Duc, H Ngo ^a   van Trommel, N E ^a   Sweep, F C G J ^a   Massuger, L F A G ^a   Thomas, Chris M G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hydatidiform mole; Hyperglycosylated human chorionic gonadotropin; Persistent trophoblastic disease

Indexed keywords

CELL ANTIGEN; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; INVASIVE TROPHOBLAST ANTIGEN; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE COURSE; FEMALE; HUMAN; HYDATIDIFORM MOLE; MAJOR CLINICAL STUDY; NETHERLANDS; PREDICTION; RADIOIMMUNOASSAY; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TROPHOBLASTIC DISEASE;

EID: 33646168058     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.5301/jbm.2008.2992     Document Type: Article

References (16)

1. Palmer JR. Advances in the epidemiology of gestational trophoblastic disease. J Reprod Med 1994; 39: 155-62.
2. Szulman AE, Surti U. The clinicopathologic profile of the partial hydatidiform mole. Obstet Gynecol 1982; 59: 597-602.
3. Berkowitz RS, Goldstein DP, Bernstein MR. Natural history of partial molar pregnancy. Obstet Gynecol 1985; 66: 677-81.
4. Khazaeli MB, Hedayat MM, Hatch KD, et al. Radioimmunoassay of free beta-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy. Am J Obstet Gynecol 1986; 155: 320-4.
5. Elliott MM, Kardana A, Lustbader JW, Cole LA. Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 1997; 7: 15-32.
6. Cole LA, Shahabi S, Oz UA, Bahado-Singh RO, Mahoney MJ. Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay. A new basis for gestational Down syndrome screening. Clin Chem 1999; 45: 2109-19.
7. Kovalevskaya G, Birken S, Kakuma T, et al. Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope. J Endocrinol 2002; 172: 497-506.
8. Kovalevskaya G, Genbacev O, Fisher SJ, Caceres E, O'Connor JF. Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol Cell Endocrinol 2002; 194: 147-55.
9. Khanlian SA, Smith HO, Cole LA. Persistent low levels of human chorionic gonadotropin: A premalignant gestational trophoblastic disease. Am J Obstet Gynecol 2003; 188: 1254-9.
10. Cole LA, Sutton JM. HCG tests in the management of gestational trophoblastic diseases. J Reprod Med 2003; 46: 523-40.
11. Yedema KA, Verheijen RH, Kenemans P, et al. Identification of patients with persistent trophoblastic disease by means of a normal human chorionic gonadotropin regression curve. Am J Obstet Gynecol 1993; 168: 787-92.
12. Thomas CM, Segers MF, Houx PC. Comparison of the analytical characteristics and clinical usefulness in tumour monitoring of fifteen hCG(-beta) immunoassay kits. Ann Clin Biochem 1985; 22: 236-46.
13. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561-77.
14. Morrow CP, Townsend DE. Tumors of the placental trophoblast. In: Morrow CP, Townsend DE, eds. Synopsis of Gynecologic Oncology, 3rd ed. New York: Wiley Medical, 1987; 367.
15. O'Connor JF, Ellish N, Kakuma T, Schlatterer J, Kovalevskaya G. Differential urinary gonadotrophin profiles in early pregnancy and early pregnancy loss. Prenat Diagn 1998; 18: 1232-40.
16. Cole LA, Khanlian SA, Sutton JM, Davies S, Stephens ND. Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection. Clin Biochem 2003; 36: 647-55.