The tortuous journey of a biochemist to immunoland and what he found there

Annual Review of Immunology

Volumn 24, Issue , 2006, Pages 1-31

  Strominger, Jack L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Bacterial cell walls; Histocompatibility proteins; HLA; MHC; NK cells; Penicillin

Indexed keywords

COMPLEMENTARY DNA; GAMMA GLUTAMYLTRANSFERASE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA D ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PENICILLIN G; PEPTIDE; PEPTIDOGLYCAN;

ANTIGEN PRESENTATION; ANTIGEN PURIFICATION; BACTERIAL CELL WALL; BACTERICIDAL ACTIVITY; BIOCHEMISTRY; CARBOHYDRATE ANALYSIS; CAREER; CATALYSIS; CATALYST; COOPERATION; CRYSTALLIZATION; DECIDUA; DECISION MAKING; DRUG RESEARCH; FUNDING; HEALTH CARE ORGANIZATION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGY; IMMUNOPRECIPITATION; JOB CHANGE; JOB PERFORMANCE; LABORATORY; MEDICAL EDUCATION; MEDICAL PROFESSION; MOLECULAR CLONING; NATURAL KILLER CELL; NONHUMAN; PHYSICIAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; TRAVEL; UNIVERSITY; X RAY CRYSTALLOGRAPHY;

ALLERGY AND IMMUNOLOGY; BIOBIBLIOGRAPHY; BIOCHEMISTRY; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HLA ANTIGENS; HUMANS; PORTRAITS; UNITED STATES;

EID: 33646165991     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.24.021605.090703     Document Type: Review

References (113)

1. Strominger J. 1948. A national science foundation. Yale. J. Biol. Med. 20:577
2. Park JT. 1952. Uridine-5′-pyrophosphate derivatives. II. Isolation from Staphylococcus aureus. J. Biol. Chem. 194:877-84
3. Reissig JL, Strominger JL, Leloir LF. 1955. A modified colorimetric method for the estimation of N-acetylamino sugars. J. Biol. Chem. 217:959-66
4. Strominger JL. 1957. Microbial uridine-5′-pyrophosphate N-acetylamino sugar compounds. I. Biology of the penicillin-induced accumulation. J. Biol. Chem. 224:509-23
5. Strominger JL, Heppel LA, Maxwell ES. 1959. Nucleoside monophosphate kinases. I. Transphosphorylation between adenosine triphosphate and nucleoside monophosphates. Biochim. Biophys. Acta 32:412-21
6. Strominger JL, Kalckar HM, Axelrod J, Maxwell ES. 1954. Enzymatic oxidation of uridine diphosphate glucose to uridine diphosphate glucuronic acid. J. Am. Chem. Soc. 76: 6411
7. Anderson EP, Isselbacher KJ, Kalckar HM. 1957. Defect in uptake of galactose-1-phosphate into liver nucleorides in congenital galactosemia. Science 125:113-14
8. Strominger JL. 1959. The amino acid sequence in the uridine nucleotide-peptide from Staphylococcus aureus. Comp. Rend. Trav. Lab. Carlsberg 31:181
9. Park JT, Strominger JL. 1957. Mode of action of penicillin. Science 125:99-101
10. Strominger JL, Park JT, Thompson RE. 1959. Composition of the cell wall of Staphylococcus aureus: its relation to the mechanism of action of penicillin. J. Biol. Chem. 234:3263-68
11. Nathenson SG, Strominger JL. 1961. Effects of penicillin on the biosynthesis of the cell walls of Escherichia coli and Staphylococcus aureus. J. Pharmacol. Exp. Ther. 131:1-6
12. Strominger JL, Ghuysen JM. 1967. Mechanisms of enzymatic bacteriaolysis. Cell walls of bacteria are solubilized by action of either specific carbohydrases or specific peptidases. Science 156:213-21
13. Strominger JL. 1970. Penicillin-sensitive enzymatic reactions in bacterial cell wall synthesis. In Harvey Lectures, pp. 179-213. New York: Academic
14. Meadow PM, Anderson JS, Strominger JL. 1964. Enzymatic polymerization of UDP-acetylmuramyl.L-ala.D-glu.L-lys.D-ala.D-ala and UDP-acetylglucosamine by a particulate enzyme from Staphylococcus aureus and its inhibition by antibiotics. Biochem. Biophys. Res. Commun. 14:382-87
15. Strominger JL, Okazaki T, Okazaki R. 1963. Oxidation and reduction of nucleotide-linked sugars. In The Enzymes, ed. P Boyer, H Lardy, K Myrback, p. 161. New York: Academic
16. Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, et al. 2005. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-34
17. Juergens WG, Sanderson AR, Strominger JL. 1963. Chemical basis for an immunological specificity of a strain of Staphylococcus aureus. J. Exp. Med. 117:925-35
18. Krueger L, Luederitz O, Strominger JL, Westphal O. 1962. [On the immunochemistry of O antigens of Enterobacteriaceae. VII. The relation of hexoses and 6-desoxyhexoses in Salmonella lipopolysaccharides to the D and L group.] Biochem Z 335:548-58
19. Izaki K, Matsuhashi M, Strominger JL. 1966. Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions. Proc. Natl. Acad. Sci. USA 55:656-63
20. Tipper DJ, Strominger JL. 1965. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proc. Natl. Acad. Sci. USA 54:1133-41
21. Lee W, McDonough MA, Kotra L, Li ZH, Silvaggi NR, et al. 2001. A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc. Natl. Acad. Sci. USA 98:1427-31
22. Anderson JS, Matsuhashi M, Haskin MA, Strominger JL. 1965. Lipid-Phosphoacetylmuramyl-pentapeptide and lipid-phosphodisaccharide- pentapeptide: presumed membrane transport intermediates in cell wall synthesis. Proc. Natl. Acad. Sci. USA 53:881-89
23. Higashi Y, Strominger JL, Sweeley CC. 1967. Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol. Proc. Natl. Acad. Sci. USA 57:1878-84
24. Matsuhashi M, Strominger JL. 1964. Thymidine diphosphate 4-acetamido-4, 6-dideoxyhexoses. I. Enzymatic synthesis by strains of Escherichia coli. J. Biol. Chem. 239:2454-63
25. Roberts WS, Petit JF, Strominger JL. 1968. Biosynthesis of the peptidoglycan of bacterial cell walls. 8. Specificity in the utilization of L-alanyl transfer ribonucleic acid for interpeptide bridge synthesis in Arthrobacter crystallopoietes. J. Biol. Chem. 243:768-72
26. Strominger JL, Threnn RH. 1959. Accumulation of a uridine nucleotide in Staphylococcus aureus as the consequence of lysine deprivation. Biochim. Biophys. Acta 36:83-92
27. Adam A, Petit JF, Lefrancier P, Lederer E. 1981. Muramyl peptides. Chemical structure, biological activity and mechanism of action. Mol. Cell. Biochem. 41:27-47
28. Janeway CA Jr, Medzhitov R. 2002. Innate immune recognition. Annu. Rev. Immunol. 20:197-216
29. Gorer PA. 1937. The genetic and antigenic basis for tumor transplantation. J. Pathol. Bacteriol. 44:691-97
30. Snell GD, Lyman S, Gorer PA. 1948. Studies on the genetic and antigenetic basis of tumor transplantation. Linkage between a histocompatibility gene and "fused" in mice. Proc. R. Soc. London Ser. B Biol. Sci. 135:499-505
31. Nathenson SG, Davies DA. 1966. Solubilization and partial purification of mouse histocompatibility antigens from a membranous lipoprotein fraction. Proc. Natl. Acad. Sci. USA 56:476-83
32. Sanderson AR, Strominger JL, Nathenson SG. 1962. Chemical structure of teichoic acid from Staphylococcus aureus, strain Copenhagen. J. Biol. Chem. 237:3603-13
33. Sanderson AR, Batchelor JR. 1968. Transplantation antigens from human spleens. Nature 219:184-86
34. Turner MJ, Cresswell P, Parham P, Strominger JL, Mann DL, Sanderson AR. 1975. Purification of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. J. Biol. Chem. 250:4512-19
35. Cresswell P, Turner MJ, Strominger JL. 1973. Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments. Proc. Natl. Acad. Sci. USA 70:1603-7
36. Grey HM, Kubo RT, Colon SM, Poulik MD, Cresswell P, et al. 1973. The small subunit of HL-A antigens is beta 2-microglobulin. J. Exp. Med. 138:1608-12
37. Cresswell P, Springer T, Strominger JL, Turner MJ, Grey HM, Kubo RT. 1974. Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc. Natl. Acad. Sci. USA 71:2123-27
38. Springer TA, Strominger JL. 1976. Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobia region. Proc. Natl. Acad. Sci. USA 73:2481-85
39. Orr HT, Lancet D, Robb RJ, Lopez de Castro JA, Strominger JL. 1979. The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. Nature 282:266-70
40. Orr HT, Lopez de Castro JA, Lancet D, Strominger JL. 1979. Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7.2. Sequence determination and search for homologies. Biochemistry 18:5711-20
41. Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, et al. 1976. Isolation and immunologic characterization of a human B-lymphocyte-specific, cell surface antigen. J. Exp. Med. 144:99-112
42. Kaufman JF, Auffray C, Korman AJ, Shackelford DA, Strominger J. 1984. The class II molecules of the human and murine major histocompatibility complex. Cell 36:1-13
43. Shackelford DA, Mann DL, van Rood JJ, Ferrara GB, Strominger JL. 1981. Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen. Proc. Natl. Acad. Sci. USA 78:4566-70
44. Ploegh HL, Orr HT, Strominger JL. 1980. Molecular cloning of a human histocompatibility antigen cDNA fragment. Proc. Natl. Acad. Sci. USA 77:6081-85
45. Orr HT, Bach FH, Ploegh HL, Strominger JL, Kavathas P, DeMars R. 1982. Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature 296:454-56
46. Koller BH, Geraghty DE, DeMars R, Duvick L, Rich SS, Orr HT. 1989. Chromosomal organization of the human major histocompatibility complex class I gene family. J. Exp. Med. 169:469-80
47. Korman AJ, Knudsen PJ, Kaufman JF, Strominger JL. 1982. cDNA clones for the heavy chain of HLA-DR antigens obtained after immunopurification of polysomes by monoclonal antibody. Proc. Natl. Acad. Sci. USA 79:1844-48
48. Korman AJ, Auffray C, Schamboeck A, Strominger JL. 1982. The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins. Proc. Natl. Acad. Sci. USA 79:6013-17
49. Auffray C, Kuo J, DeMars R, Strominger JL. 1983. A minimum of four human class II alpha-chain genes are encoded in the HLA region of chromosome 6. Nature 304:174-77
50. Roux-Dosseto M, Auffray C, Lillie JW, Boss JM, Cohen D, et al. 1983. Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex. Proc. Natl. Acad. Sci. USA 80:6036-40
51. Steinmetz M, Minard K, Horvath S, McNicholas J, Srelinger J, et al. 1982. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300:35-42
52. Okada K, Boss JM, Prentice H, Spies T, Mengler R, et al. 1985. Gene organization of DC and DX subregions of the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 82:3410-14
53. Spies T, Sorrentino R, Boss JM, Okada K, Strominger JL. 1985. Structural organization of the DR subregion of the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 82:5165-69
54. Spies T, Morton CC, Nedospasov SA, Fiers W, Pious D, Strominger JL. 1986. Genes for the tumor necrosis factors α and β are linked to the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 83:8699-702
55. Carroll MC, Katzman P, Alicot EM, Koller BH, Geraghty DE, et al. 1987. Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. Proc. Natl. Acad. Sci. USA 84:8535-39
56. Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL. 1989. A new cluster of genes within the human major histocompatibility complex. Science 243:214-17
57. Bahram S, Spies T. 1996. The MIC gene family. Res. Immunol. 147:328-33
58. Orr HT, Lopez de Castro JA, Parham P, Ploegh HL, Strominger JL. 1979. Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc. Natl. Acad. Sci. USA 76:4395-99
59. Bjorkman PJ, Strominger JL, Wiley DC. 1985. Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J. Mol. Biol. 186:205-10
60. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. 1987. Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506-12
61. Koller BH, Orr HT. 1985. Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level. J. Immunol. 134:2727-33
62. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512-18
63. Garrett TP, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC. 1989. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342:692-96
64. Gorga JC, Madden DR, Prendergast JK, Wiley DC, Strominger JL. 1992. Crystallization and preliminary X-ray diffraction studies of the human major histocompatibility antigen HLA-B27. Proteins 12:87-90
65. Madden DR, Gorga JC, Strominger JL, Wiley DC. 1992. The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC. Cell 70:1035-48
66. Silver ML, Guo HC, Strominger JL, Wiley DC. 1992. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature 360:367-69
67. Gorga JC, Horejsi V, Johnson DR, Raghupathy R, Strominger JL. 1987. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J. Biol. Chem. 262:16087-94
68. Gorga JC, Brown JH, Jardetzky T, Wiley DC, Strominger JL. 1991. Crystallization of HLA-DR antigens. Res. Immunol. 142:401-7
69. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, et al. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364:33-39
70. Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, et al. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368:711-18
71. Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, et al. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368:215-21
72. 71a. Chicz RM, Urban RG, Lane WS, Gorga JC, Stern LJ, et al. 1992. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature 358:764-68
73. 71b. Chicz RM, Urban RG, Gorga JC, Vignali DAA, Lane WS, Strominger JL. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27-47
74. 71c. Strominger JL. 2002. Don Craig Wiley (1944-2001): a reminiscence. Nat. Immunol. 2:103-4
75. Svejgaard A, Platz P, Ryder LP. 1983. HLA and disease 1982-a survey. Immunol. Rev. 70:193-218
76. Teitelbaum D, Webb C, Meshorer A, Arnon R, Sela M. 1973. Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen. Eur. J. Immunol. 3:273-79
77. Fridkis-Hareli M, Santambrogio L, Stern JN, Fugger L, Brosnan C, Strominger JL. 2002. Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis. J. Clin. Invest. 109:1635-43
78. Stern JN, Illes Z, Reddy J, Keskin DB, Sheu E, et al. 2004. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc. Natl. Acad. Sci. USA 101:11743-48
79. Illes Z, Stern JN, Reddy J, Waldner H, Mycko MP, et al. 2004. Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc. Natl. Acad. Sci. USA 101:11749-54
80. Stern JN, Illes Z, Reddy J, Keskin DB, Fridkis-Hareli M, et al. 2005. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 102:1620-25
81. + natural killer cells requires the expression of an autosomic recessive gene on target cells. J. Exp. Med. 172:47-52
82. Ciccone E, Colonna M, Viale O, Pende D, Di Donato C, et al. 1990. Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. Proc. Natl. Acad. Sci. USA 87:9794-97
83. correction in Proc. Natl. Acad. USA 88:5477
84. Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, et al. 1992. Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans. J. Exp. Med. 175:709-18
85. Colonna M, Spies T, Strominger JL, Ciccone E, Moretta A, et al. 1992. Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene. Proc. Natl. Acad. Sci. USA 89:7983-85
86. Colonna M, Borsellino G, Falco M, Ferrara GB, Strominger JL. 1993. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc. Natl. Acad. Sci. USA 90:12000-4
87. Mandelboim O, Reyburn HT, Vales-Gomez M, Pazmany L, Colonna M, et al. 1996. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J. Exp. Med. 184:913-22
88. Colonna M, Samaridis J. 1995. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268:405-8
89. Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, et al. 1995. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 2:439-49
90. Cella M, Longo A, Ferrara GB, Strominger JL, Colonna M. 1994. NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80. J. Exp. Med. 180:1235-42
91. D'Andrea A, Chang C, Franz-Bacon K, McClanahan T, Phillips JH, Lanier LL. 1995. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306-10
92. Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL. 1999. The human natural killer cell immune synapse. Proc. Natl. Acad. Sci. USA 96:15062-67
93. Orange JS, Harris KE, Andzelm MM, Valter MM, Geha RS, Strominger JL. 2003. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc. Natl. Acad. Sci. USA 100:14151-56
94. Deleted in proof
95. Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL. 2002. Viral evasion of natural killer cells. Nat. Immunol. 3:1006-12
96. Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, et al. 2003. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J. Exp. Med. 198:1201-12
97. Kopcow HD, Allan DS, Ge B, Rybalov B, Andzelm MM, et al. 2005. Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc. Natl. Acad. Sci. USA. 43:15563-68
98. Skare J, Strominger JL. 1980. Cloning and mapping of BamHi endonuclease fragments of DNA from the transforming B95-8 strain of Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 77:3860-64
99. Schaefer BC, Woisetschlaeger M, Strominger JL, Speck SH. 1991. Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes. Proc. Natl. Acad. Sci. USA 88:6550-54
100. Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA, Fearon DT. 1984. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc. Natl. Acad. Sci. USA 81:4510-14
101. Hemler ME, Ware CF, Strominger JL. 1983. Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J. Immunol. 131:334-40
102. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, et al. 1986. Identification of a putative second T-cell receptor. Nature 322:145-49
103. Spies T, Bresnahan M, Strominger JL. 1989. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. Proc. Natl. Acad. Sci. USA 86:8955-58
104. Wong SH, Santambrogio L, Strominger JL. 2004. Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins. Proc. Natl. Acad. Sci. USA 101:17783-88
105. Santambrogio L, Potolicchio I, Fessler SP, Wong SH, Raposo G, Strominger JL. 2005. Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells. Nat. Immunol. 6:1020-28
106. + cytotoxic T lymphocyte: clones. J. Immunol. 129:2001-3
107. Kohler G, Milstein C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-97
108. Herzenberg LA, Herzenberg LA. 2004. Genetics, FACS, immunology, and redox: a tale of two lives intertwined. Annu. Rev. Immunol. 22:1-31
109. Ploegh HL, Orr HT, Strominger JL. 1981. Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell 24:287-99
110. Chicz RM, Urban RG, Gorga JC, Vignali DA, Lane WS, Strominger JL. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27-47
111. Stern LJ, Wiley DC. 1994. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2:245-51
112. Madden DR. 1995. The three-dimensional structure of peptide-MHC complexes. Annu. Rev. Immunol. 13:587-622
113. Latron F, Pazmany L, Morrison J, Moots R, Saper MA, et al. 1992. A critical role for conserved residues in the cleft of HLA-A2 in presentation of a nonapeptide to T cells. Science 257:964-67