Role of aromatic localization in the gating process of a potassium channel

Biophysical Journal

Volumn 90, Issue 1, 2006, Pages

  Domene, Carmen ^a   Vemparala, Satyavani ^b   Klein, Michael L ^b   Vénien Bryan, Catherine ^c   Doyle, Declan A ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; LIPID; MEMBRANE PROTEIN; POTASSIUM CHANNEL;

ARTICLE; ATOM; CHANNEL GATING; CONFORMATIONAL TRANSITION; MOLECULAR DYNAMICS; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SIMULATION;

EID: 33646151399     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.072116     Document Type: Article

References (13)

1. Roux, B. 2005. Ion conduction and selectivity in K(1) channels. Annu. Rev. Biophys. Biomol. Struct. 34:153-171.
2. Kuo, A., J. M. Gulbis, J. F. Antcliff, T. Rahman, E. D. Lowe, Z. Jochen, J. Cuthbertson, F. M. Ashcroft, T. Ezaki, and D. A. Doyle. 2003. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science. 300:1922-1926.
3. Domene, C., D. A. Doyle, and C. Venien-Bryan. 2005. Modeling of an ion channel in its open conformation. Biophys. J. 89:L01-L03.
4. Kuo, A., C. Domene, L. N. Johnson, D. A. Doyle, and C. Venien-Bryan. 2005. Two different conformational states of KirBac3.1 potassium channel revealed by electron crystallography. Structure. 13:1463-1472.
5. Arkin, I., and A. Brunger. 1998. Statistical analysis of predicted transmembrane alpha-helices. Biochim. Biophys. Acta. 1429:113-128.
6. Persson, S., J. A. Killian, and G. Lindblom. 1998. Molecular ordering of interfacially localized tryptophan analogs in ester- and ether-lipid bilayers studied by H-2-NMR. Biophys. J. 75:1365-1371.
7. Braun, P., and G. von Heijne. 1999. The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane. Biochemistry. 38:9778-9782.
8. Hu, W., K. C. Lee, and T. A. Cross. 1993. Tryptophans in membrane-proteins - indole ring orientations and functional implications in the gramicidin channel. Biochemistry. 32:7035-7047.
9. Gaede, H., W. Yau, and K. Gawrisch. 2005. Electrostatic contributions to indole-lipid interactions. J. Phys. Chem. B. 109:13014-13023.
10. Shealy, R. T., A. D. Murphy, R. Ramarathnam, E. Jakobsson, and S. Subramaniam. 2003. Sequence-function analysis of the K-selective family of ion channels using a comprehensive alignment and the KcsA channel structure. Biophys. J. 84:2929-2942.
11. Tieleman, D. P., L. R. Forrest, M. S. P. Sansom, and H. J. C. Berendsen. 1998. Lipid properties and the orientation of aromatic residues in OmpF, influenza M2, and alamethicin systems: molecular dynamics simulations. Biochemistry. 37:17554-17561.
12. Domene, C., P. J. Bond, S. S. Deol, and M. S. P. Sansom. 2003. Lipid/ protein interactions and the membrane/water interfacial region. J. Am. Chem. Soc. 125:14966-14967.
13. Ulmschneider, M. B., and M. S. P. Sansom. 2001. Amino acid distributions in integral membrane protein structures. Biochim. Biophys. Acta. 1512:1-14.