Blood flow sensor susceptibility to lipoproteins in early arteriosclerosis and its clinical improvement by statin therapy - a nanoplaque study

Desalination

Volumn 191, Issue 1-3, 2006, Pages 417-425

  Siegel, G ^a   Rodriguez M ^a   Schon T ^a   Abletshauser, C ^b   Schmidt, A ^c   Hetzer, R ^d   Malmsten, M ^e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Clinical Research   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Arteriosclerosis model; Blood flow sensor; Clinical trial; Ellipsometry; Fluvastatin; Lipoprotein binding receptor; Nanoplaque formation; Proteoglycan receptor

Indexed keywords

CELL MEMBRANES; ELLIPSOMETRY; MUSCLE; TRANSPLANTATION (SURGICAL);

ARTERIOSCLEROSIS MODEL; BLOOD FLOW SENSOR; BLOOD LIPOPROTEIN FRACTIONS; HUMAN CORONARY ARTERIES; NANOPLAQUE FORMATION; PROTEOGLYCAN RECEPTOR; STATIN THERAPY;

BODY FLUIDS;

BODY FLUIDS; CELL MEMBRANES; ELLIPSOMETRY; MUSCLE; TRANSPLANTATION (SURGICAL);

BLOOD; DISEASE; FLUID FLOW; PROTEIN;

EID: 33646131213     PISSN: 00119164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.desal.2005.09.016     Document Type: Article

References (26)

1. Trescony P.V., Oegema Jr. T.R., Farnam B.J., and Deloria L.B. Analysis of heparan sulfate from the Engelbreth-Holm-Swarm (EHS) tumor. Connect. Tissue Res. 19 (1989) 219-242
2. Siegel G. Connective tissue: more than just a matrix for cells. In: Greger R., and Windhorst U. (Eds). Comprehensive Human Physiology vol. 1 (1996), Springer-Verlag, Berlin, Heidelberg 173-224
3. Timpl R. Proteoglycans of basement membranes. Experientia 49 (1993) 417-428
4. Olgemöller B., Schleicher E.D., Schwaabe S., Guretzki H.-J., and Gerbitz K.D. High concentrations of low density lipoprotein decrease basement membrane-associated heparan sulfate proteoglycan in cultured endothelial cells. FEBS Lett. 264 (1990) 37-39
5. Siegel G., Malmsten M., Klüßendorf D., and Leonhardt W. Physicochemical binding properties of the proteoglycan receptor for serum lipoproteins. Atherosclerosis 144 (1999) 59-67
6. Siegel G., Malmsten M., Klüßendorf D., and Michel F. A receptor-based biosensor for lipoprotein docking at the endothelial surface and vascular matrix. Biosensors & Bioelectronics 16 (2001) 895-904
7. Schmidt A., and Buddecke E. Cell-associated proteoheparan sulfate from bovine arterial smooth muscle cells. Exp. Cell Res. 178 (1988) 242-253
8. Schmidt A., Schäfer E., and Buddecke E. Isolation and characterization of two proteoheparan sulfate species of calf arterial tissue. Eur. J. Biochem. 173 (1988) 661-666
9. Siegel G., Walter A., Kauschmann A., Malmsten M., and Buddecke E. Anionic biopolymers as blood flow sensors. Biosensors & Bioelectronics 11 (1996) 281-294
10. Havel R.J., Eder H.A., and Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human plasma. J. Clin. Invest. 34 (1955) 1345-1353
11. Siegel G., Walter A., Bostanjoglo M., Jans A.W.H., Kinne R., Piculell L., and Lindman B. Ion transport and cation-polyanion interactions in vascular biomembranes. J. Membr. Sci. 41 (1989) 353-375
12. Siegel G., Walter A., Rückborn K., Buddecke E., Schmidt A., Gustavsson H., and Lindman B. NMR studies of cation induced conformational changes in anionic biopolymers at the endothelium-blood interface. Polym. J. 23 (1991) 697-708
13. Azzam R.M.A., and Bashara N.M. Ellipsometry and Polarized Light (1989), North-Holland, Amsterdam
14. 2 surfaces by means of ellipsometry, using different ambient media. J. Phys. Chem. 97 (1993) 1656-1660
15. Malmsten M. Ellipsometry studies of protein layers adsorbed at hydrophobic surfaces. J. Colloid Interface Sci. 166 (1994) 333-342
16. De Feijter J.A., Benjamins J., and Veer F.A. Ellipsometry as a tool to study the adsorption behavior of synthetic and biopolymers at the air-water interface. Biopolymers 17 (1978) 1759-1772
17. Malmsten M., Siegel G., Buddecke E., and Schmidt A. Cation-promoted adsorption of proteoheparan sulphate. Coll. Surf. B: Biointerfaces 1 (1993) 43-50
18. Siegel G., Malmsten M., Klüßendorf D., Walter A., Schnalke F., and Kauschmann A. Blood-flow sensing by anionic biopolymers. J. Auton. Nerv. Syst. 57 (1996) 207-213
19. Siegel G., Rückborn K., Schnalke F., and Grote J. Membrane physiological reactions of human arteriosclerotic coronary arteries to hypoxia. J. Cardiovasc. Pharmacol., Suppl. 12 20 (1992) S217-S220
20. Siegel G., Schnalke F., Schaarschmidt J., Müller J., and Hetzer R. Hypoxia and vascular muscle tone in normal and arteriosclerotic human coronary arteries. J. Vasc. Med. Biol. 3 (1991) 140-149
21. Siegel G., Malmsten M., and Schmidt A. Flow sensing at the endothelial cell membrane-blood interface. J. Membr. Sci. 113 (1996) 101-113
22. Malmsten M., Claesson P., and Siegel G. Forces between proteoheparan sulfate layers adsorbed at hydrophobic surfaces. Langmuir 10 (1994) 1274-1280
23. Siegel G., Malmsten M., Klüssendorf D., and Hofer H.-W. Vascular smooth muscle, a multiply feedback-coupled system of high versatility, modulation and cell-signaling variability. Int. J. Microcirc. 17 (1997) 360-373
24. G. Siegel and M. Malmsten, Molecular model for athero/arteriosclerosis, patent EP 0 946 876, 2005.
25. Abletshauser C., Klüßendorf D., Schmidt A., Winkler K., März W., Buddecke E., Malmsten M., and Siegel G. Biosensing of arteriosclerotic nanoplaque formation and interaction with an HMG-CoA reductase inhibitor. Acta Physiol. Scand. 176 (2002) 131-145
26. Siegel G., Abletshauser C., Malmsten M., Schmidt A., and Winkler K. Reduction of arteriosclerotic nanoplaque formation and size by fluvastatin in a receptor-based biosensor model. Cardiovasc. Res. 58 (2003) 696-705