Importance of extracardiac α1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts

European Journal of Pharmacology

Volumn 537, Issue 1-3, 2006, Pages 118-125

  Farkas, Attila S ^a   Acsai, Károly ^b   Tóth, András ^b   Dézsi, László ^c   Orosz, Szabolcs ^c   Forster, Tamás ^a   Csanády, Miklós ^a   Papp, Julius Gy ^b,d   Varró, András ^b   Farkas, András ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c GEDEON RICHTER LTD   (Hungary)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

1 Adrenergic receptor; Proarrhythmia; QT interval; Repolarization prolongation; Torsade de pointes; Ventricular stretch

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DOFETILIDE; METHOXAMINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIARRHYTHMIC AGENT; PHENETHYLAMINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FILLING PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE PERFUSION; HEART RATE; HEART REPOLARIZATION; HEART WORK; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; QT PROLONGATION; RABBIT; RECEPTOR INTRINSIC ACTIVITY; SYSTOLE; TORSADE DES POINTES; ANIMAL; BLOOD FLOW; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG POTENTIATION; ELECTROCARDIOGRAPHY; HEART VENTRICLE; IN VITRO STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HEART VENTRICLES; METHOXAMINE; PHENETHYLAMINES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-1; REGIONAL BLOOD FLOW; SULFONAMIDES; TORSADES DE POINTES;

EID: 33646128726     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.03.014     Document Type: Article

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