Vasoactive intestinal polypeptide receptor antagonism enhances the vagally induced increase in cardiac interval of the rat atrium in vitro

Experimental Physiology

Volumn 91, Issue 3, 2006, Pages 641-646

  Hogan, K ^a   Markos, F ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM IODIDE; ATENOLOL; HEXAMETHONIUM; NICOTINE; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; VASOACTIVE INTESTINAL POLYPEPTIDE[6-28];

ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG EFFECT; HEART FUNCTION; HEART RIGHT ATRIUM; MALE; NONHUMAN; RAT; SINUS NODE; VAGUS NERVE STIMULATION;

EID: 33646120828     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2006.033605     Document Type: Article

References (18)

1. Cuevas J & Adams DJ 1996 Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones J Physiol 493 503 515
2. Daly M De B 1997 In Peripheral Arterial Chemoreceptors and Respiratory-Cardiovascular Integration Appendix I pp. 597 604 Oxford University Press Oxford
3. Fishbein VA Coy DH Hocart SJ Jiang NY Mrozinski JE Jr. Mantey SA & Jensen RT 1994 A chimeric VIP-PACAP analogue but not VIP pseudopeptides function as VIP receptor antagonists Peptides 15 95 100
4. Henning RJ & Sawmiller DR 2001 Vasoactive intestinal peptide: cardiovascular effects Cardiovasc Res 49 27 37
5. Hill MR Wallick DW Martin PJ & Levy MN 1995 Effects of repetitive vagal stimulation on heart rate and on cardiac vasoactive intestinal polypeptide efflux Am J Physiol 268 H1939 H1946
6. Hogan K & Markos F 2006 An investigation into the presence of the vagal tachycardia and the effect of vasoactive intestinal polypeptide (VIP) on rat heart rate in vitro Pharmacology 76 101 104
7. Markos F Hennessy BA Fitzpatrick M O'Sullivan J & Snow HM 2002 An evaluation of the efficacy of vasoactive intestinal polypeptide (VIP) antagonists in vivo in the anaesthetised dog Pharmacology 66 206 210
8. Markos F & Snow HM 2001 The potentiation of sinus arrhythmia by vasoactive intestinal polypeptide (VIP) in the anaesthetized dog Neuropeptides 35 238 243
9. Markos F & Snow HM 2006 An investigation into the physiological relevance of the vagal tachycardia in the anaesthetized dog Acta Physiol 186 179 184
10. Pandol SJ Dharmsathaphorn K Schoeffield MS Vale W & Rivier J 1986 Vasoactive intestinal peptide receptor antagonist [4Cl- d -Phe6, Leu17] VIP Am J Physiol 250 G553 G557
11. Randall WC Wurster RD Randall DC & Xi-Moy SX 1996 From cardioaccelerator and inhibitory nerves to a 'heart brain': an evolution of concepts In Nervous Control of the Heart ed Shepherd JT & Vatner SF pp. 173 199 Harwood Academic Amsterdam
12. Richardson RJ Grkovic I & Anderson CR 2003 Immunohistochemical analysis of intracardiac ganglia of the rat heart Cell Tissue Res 314 337 350
13. Rigel DF 1988 Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT Am J Physiol 255 H311 H317
14. Shvilkin A Danilo P Jr. Chevalier P Chang F Cohen IS & Rosen MR 1994 Vagal release of vasoactive intestinal peptide can promote vagotonic tachycardia in the isolated innervated rat heart Cardiovasc Res 28 1769 1773
15. Svoboda M De Neef P Tastenoy M & Christophe J 1988 Molecular characteristics and evidence for internalization of vasoactive-intestinal-peptide (VIP) receptors in the tumoral rat-pancreatic acinar cell line AR 4-2 J Eur J Biochem 176 707 713
16. Sweeney C & Markos F 2004 The role of neuronal nitric oxide (NO) in the vagal control of cardiac interval of the rat heart in vitro Auton Neurosci 111 110 115
17. Van Geldre LA & Lefebvre RA 2004 Interaction of NO and VIP in gastrointestinal smooth muscle relaxation Current Pharmaceut Design 10 2483 2497
18. Weihe E Reinecke M & Forssmann WG 1984 Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin- and substance P-like immunoreactive nerves Cell Tissue Res 236 527 540