Effects of Brn-3a protein and RNA expression in rat brain following low-level lead exposure during development on spatial learning and memory

Toxicology Letters

Volumn 164, Issue 1, 2006, Pages 63-70

  Chang, Wei ^a,b   Chen, Jun ^a   Wei, Qing yi ^a   Chen, Xue min ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Guangdong Prevention and Treatment Center for Occupational Diseases   (China)

Author keywords

Brn 3a; Developing nervous system; Lead (Pb2+); POU domain protein

Indexed keywords

LEAD ACETATE; MESSENGER RNA; PROTEIN; PROTEIN BRN 3A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CEREBELLUM; COGNITIVE DEVELOPMENT; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LEAD POISONING; LEARNING; MAZE TEST; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SPATIAL MEMORY; TISSUE DISTRIBUTION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMMUNOHISTOCHEMISTRY; LEAD; MAZE LEARNING; MEMORY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPATIAL BEHAVIOR; TRANSCRIPTION FACTOR BRN-3A;

ANIMALIA;

EID: 33646114741     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.11.011     Document Type: Article

References (25)

1. Bellinger D.C., Leviton A., Allred E., and Rabinowitz M. Pre- and postnatal lead exposure and behavior problems in school-aged children. Environ. Res 66 (1994) 12-30
2. Budhram-Mahadeo V.S., Morris P.J., Lakin N.D., Theil T., Ching G.Y., Lillycrop K.A., Möröy T., Liem R.K.H., and Latchman D.S. Activation of the a-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. J. Biol. Chem. 270 (1995) 2853-2858
3. Chen J., Zhu W.G., and Chen X.M. Effects of lead on Brn-3a expression and apoptosis in hippocampus neurons. J. Hygiene Res. 33 (2004) 134-136
4. Fedtsova N.G., and Turner E.E. Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech. Dev. 53 (1996) 291-304
5. Gerrero M.R., McEvilly R.J., Tuner E., Lin C.R., O'Connell S., Jenne K.J., Hobbs M.V., and Rosenfeld M.G. Brn 3.0: a POU domain protein expressed in the sensory immune and endocrine systems that functions on elements distinct from known octamer motifs. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10841-10845
6. He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.S., and Rosenfeld M.G. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 340 (1989) 35-42
7. Jett D.A., Kuhlmann A.C., Farmer S.J., and Guilarte T.R. Age-dependent effects of developmental lead exposure on performance in the Morris water maze. Pharmacol. Biochem. Behav. 57 (1997) 271-279
8. Kuhlmann A.C., McGlothan J.L., and Guilarte T.R. Developmental lead exposure causes spatial learning deficits in adult rats. Neurosci. Lett. 233 (1997) 101-104
9. Lakin N.D., Morris P.J., Theil T., Sato T.N., Moroy T., Wilson M.C., and Latchman D.S. Regulation of neurite outgrowth and SNAP-25 gene expression by the Brn-3a transcription factor. J. Biol. Chem. 270 (1995) 15858-15863
10. Lillycrop K.A., Budhram-Mahadeo V.S., Lakin N.D., Terrenghi G., Wood J.N., Polak J.M., and Latchman D.S. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. Nucleic Acids Res. 20 (1992) 5093-5096
11. McEvilly R.J., Erkman L., Luo L., Sawchenko P.E., Ryan A.F., and Rosenfeld M.G. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384 (1996) 574-577
12. Needleman H.L. Childhood lead poisoning. Curr. Opin. Neurol. 7 (1994) 187-190
13. 2+ during development. Mol. Brain Res. 66 (1999) 42-49
14. Rice D.C. Lead-induced changes in learning: evidence for behavioral mechanisms from experimental animal studies. Neurotoxicology 14 (1993) 167-178
15. Ryan A.K., and Rosenfeld M.G. POU domain family values: flexibility, partnerships and developmental codes. Genes Dev. 11 (1997) 1207-1225
16. Smith M.D., Dawson S.J., and Latchman D.S. The Brn-3a transcription factor induces neuronal process outgrowth and the co-ordinate expression of genes encoding synaptic proteins. Mol. Cell Biol. 17 (1997) 345-354
17. Smith M.D., Morris P.J., Dawson P.J., Schwartz M.L., Schlaepfer W.W., and Latchman D.S. Co-ordinate induction of the three neurofilament genes by the Brn-3a transcription factor. J. Biol. Chem. 272 (1997) 21325-21333
18. Smith M.D., Ensor E.A., Coffin R.S., Boxer L.M., and Latchman D.S. Bcl-2 transcription from the proximal p2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor. J. Biol. Chem. 273 (1998) 16715-16722
19. Smith M.D., Dawson S.J., Boxer L.M., and Latchman D.S. The Nterminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bcl-2 gene expression. Nucleic Acids Res. 26 (1998) 4100-4107
20. Vasconcellos A.P.S., Tabajara A.S., Ferrari C., Rocha E., and Dalmaz C. Effect of chronic stress on spatial memory in rats is attenuated by lithium treatment. Physiol. Behav. 79 (2003) 143-149
21. Verrijzer C.P., and van der Vliet P.C. POU domain transcription factors. Biochim. Biophys. Acta 1173 (1993) 1-21
22. Wegner M., Drolet D.W., and Rosenfeld M.G. POU-domain proteins: structure and function of developmental regulators. Curr. Opin. Dev. Biol. 5 (1993) 488-498
23. Winneke G. Inorganic lead as a developmental neurotoxicant some basic issues and the dusseldorf expeience. Neurotoxicology 17 (1996) 565-580
24. Wood J.N., Bevan S.J., Coote P., Darn P.M., Harmar A., Hogan P., Latchman D.S., Morrison C., Rougon G., Theiveniau M., and Wheatley S.C. Novel cell lines display properties of nociceptive sensory neurons. Proc. R. Soc. Lond. [Biol.] 241 (1990) 187-194
25. Xiang M., Gan L., Zhou L., Klein W.H., and Nathans J. Targetted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 11950-11955