Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles

Journal of Leukocyte Biology

Volumn 79, Issue 3, 2006, Pages 564-573

  Pellmé, Sara ^a   Mörgelin, Matthias ^b   Tapper, Hans ^b   Mellqvist, Ulf Henrik ^c   Dahlgren, Claes ^a   Karlsson, Anna ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cell activation; Chemokines; Inflammation; Subcellular organization

Indexed keywords

CALNEXIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; BIOLOGICAL MARKER;

ARTICLE; CELL GRANULE; CELL ISOLATION; CELL ORGANELLE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SECRETORY VESICLE; CELL CULTURE; CELL FRACTIONATION; CYTOCHEMISTRY; DRUG EFFECT; ENDOPLASMIC RETICULUM; IMMUNOLOGY; INTRACELLULAR MEMBRANE; METABOLISM; NEUTROPHIL; SECRETION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

BIOLOGICAL MARKERS; CALNEXIN; CELLS, CULTURED; CYTOPLASMIC GRANULES; ENDOPLASMIC RETICULUM; HISTOCYTOCHEMISTRY; HUMANS; INTERLEUKIN-8; INTRACELLULAR MEMBRANES; LIPOPOLYSACCHARIDES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, IMMUNOELECTRON; NEUTROPHILS; ORGANELLES; SECRETORY VESICLES; SUBCELLULAR FRACTIONS;

EID: 33646110529     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0505248     Document Type: Article

References (46)

1. Ye, R. D., Boulay, F. (1997) Structure and function of leukocyte chemoattractant receptors. Adv. Pharmacol. 39, 221-289.
2. Yoshimura, T., Matsushima, K., Tanaka, S., Robinson, E. A., Appella, E., Oppenheim, J. J., Leonard, E. J. (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl. Acad. Sci. USA 84, 9233-9237.
3. Leonard, E. J., Yoshimura, T., Tanaka, S., Raffeld, M. (1991) Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1. J. Invest. Dermatol. 96, 690-694.
4. Kuhns, D. B., DeCarlo, E., Hawk, D. M., Gallin, J. I. (1992) Dynamics of the cellular and humoral components of the inflammatory response elicited in skin blisters in humans. J. Clin. Invest. 89, 1734-1740.
5. Follin, P., Wymann, M. P., Dewald, B., Ceska, M., Dahlgren, C. (1991) Human neutrophil migration into skin chambers is associated with production of NAP-1/IL-8 and C5a. Eur. J. Haematol. 47, 71-76.
6. Kuhns, D. B., Gallin, J. I. (1995) Increased cell-associated IL-8 in human exudative and A23187-treated peripheral blood neutrophils. J. Immunol. 154, 6556-6562.
7. He, R., Sang, H., Ye, R. D. (2003) Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood 101, 1572-1581.
8. Cassatella, M. A., Bazzoni, F., Ceska, M., Ferro, I., Baggiolini, M., Berton, G. (1992) IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway. J. Immunol. 148, 3216-3220.
9. Kuhns, D. B., Nelson, E. L., Alvord, W. G., Gallin, J. I. (2001) Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine or leukotriene B(4). J. Immunol. 167, 2869-2878.
10. Kuhns, D. B., Young, H. A., Gallin, E. K., Gallin, J. I. (1998) Ca2+-dependent production and release of IL-8 in human neutrophils. J. Immunol. 161, 4332-4339.
11. Bazzoni, F., Cassatella, M. A., Rossi, F., Ceska, M., Dewald, B., Baggiolini, M. (1991) Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8. J. Exp. Med. 173, 771-774.
12. Marie, C., Roman-Roman, S., Rawadi, G. (1999) Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Infect. Immun. 67, 688-693.
13. Taieb, J., Delarche, C., Ethuin, F., Selloum, S., Poynard, T., Gougerot-Pocidalo, M. A., Chollet-Martin, S. (2002) Ethanol-induced inhibition of cytokine release and protein degranulation in human neutrophils. J. Leukoc. Biol. 72, 1142-1147.
14. Fäldt, J., Dahlgren, C., Ridell, M., Karlsson, A. (2001) Priming of human neutrophils by mycobacterial lipoarabinomannans: role of granule mobilization. Microbes Infect. 3, 1101-1109.
15. Fujishima, S., Hoffman, A. R., Vu, T., Kim, K. J., Zheng, H., Daniel, D., Kim, Y., Wallace, E. F., Larrick, J. W., Raffin, T. A. (1993) Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-α, and IL-1 β. J. Cell. Physiol. 154, 478-485.
16. Borregaard, N., Lollike, K., Kjeldsen, L., Sengeløv, H., Bastholm, L., Nielsen, M. H., Bainton, D. F. (1993) Human neutrophil granules and secretory vesicles. Eur. J. Haematol. 51, 187-198.
17. Borregaard, N., Cowland, J. B. (1997) Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89, 3503-3521.
18. Bainton, D. F. (1999) Distinct granule populations in human neutrophils and lysosomal organelles identified by immuno-electron microscopy. J. Immunol. Methods 232, 153-168.
19. Dahlgren, C., Carlsson, S. R., Karlsson, A., Lundqvist, H., Sjölin, C. (1995) The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils. Biochem. J. 311, 667-674.
20. Cieutat, A. M., Lobel, P., August, J. T., Kjeldsen, L., Sengeløv, H., Borregaard, N., Bainton, D. F. (1998) Azurophilic granules of human neutrophilic leukocytes are deficient in lysosome-associated membrane proteins but retain the mannose 6-phosphate recognition marker. Blood 91, 1044-1058.
21. Kjeldsen, L., Bjerrum, O. W., Hovgaard, D., Johnsen, A. H., Sehested, M., Borregaard, N. (1992) Human neutrophil gelatinase: a marker for circulating blood neutrophils. Purification and quantitation by enzyme linked immunosorbent assay. Eur. J. Haematol. 49, 180-191.
22. Kjeldsen, L., Sengeløv, H., Lollike, K., Nielsen, M. H., Borregaard, N. (1994) Isolation and characterization of gelatinase granules from human neutrophils. Blood 83, 1640-1649.
23. Sengelov, H., Nielsen, M. H., Borregaard, N. (1992) Separation of human neutrophil plasma membrane from intracellular vesicles containing alkaline phosphatase and NADPH oxidase activity by free flow electrophoresis. J. Biol. Chem. 267, 14912-14917.
24. Boyum, A., Lovhaug, D., Tresland, L., Nordlie, E. M. (1991) Separation of leucocytes: improved cell purity by fine adjustments of gradient medium density and osmolality. Scand. J. Immunol. 34, 697-712.
25. Borregaard, N., Heiple, J. M., Simons, E. R., Clark, R. A. (1983) Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation. J. Cell Biol. 97, 52-61.
26. Kjeldsen, L., Sengeløv, H., Borregaard, N. (1999) Subcellular fractionation of human neutrophils on Percoll density gradients. J. Immunol. Methods 232, 131-143.
27. Feuk-Lagerstedt, E., Jordan, E. T., Leffler, H., Dahlgren, C., Karlsson, A. (1999) Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. J. Immunol. 163, 5592-5598.
28. Dahlgren, C., Karlsson, A., Sendo, F. (2001) Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential. J. Leukoc. Biol. 69, 57-62.
29. Tapper, H., Karlsson, A., Mörgelin, M., Flodgaard, H., Herwald, H. (2002) Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood 99, 1785-1793.
30. Dahlgren, C., Karlsson, A. (1999) Respiratory burst in human neutrophils. J. Immunol. Methods 232, 3-14.
31. Carleman, E., Villiger W., Hotot, J. A., Acetarin, J. D., Kellenberger, E. (1985) Low temperature embedding with Lowicryl resins: two new formulas and some applications. J. Microse. 140 (Pt 1) 55-63.
32. Roos, D., Voetman, A. A., Meerhof, L. J. (1983) Functional activity of enucleated human polymorphonuclear leukocytes. J. Cell Biol. 97, 368-377.
33. Movitz, C., Dahlgren, C. (2001) Quantification of annexin I in subcellular fractions of human neutrophils reveals an exclusive cytosolic localization. Cell Biol. Int. 25, 963-969.
34. Helenius, A., Aebi, M. (2004) Roles of N-linked glycans in the endoplasmic reticulum. Annu. Rev. Biochem. 73, 1019-1049.
35. Molinari, M., Eriksson, K. K., Calanca, V., Galli, C., Cresswell, P., Michalak, M., Helenius, A. (2004) Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Mol. Cell 13, 125-135.
36. Lund, T., Osterud, B. (2004) The effect of TNF-α, PMA, and LPS on plasma and cell-associated IL-8 in human leukocytes. Thromb. Res. 113, 75-83.
37. Wertheim, W. A., Kunkel, S. L., Standiford, T. J., Burdick, M. D., Becker, F. S., Wilke, C. A., Gilbert, A. R., Strieter, R. M. (1993) Regulation of neutrophil-derived IL-8: the role of prostaglandin E2, dexamethasone, and IL-4. J. Immunol. 151, 2166-2175.
38. Sengelov, H., Borregaard, N. (1999) Free-flow electrophoresis in subcellular fractionation of human neutrophils. J. Immunol. Methods 232, 145-152.
39. Kobayashi, T., Robinson, J. M. (1991) A novel intracellular compartment with unusual secretory properties in human neutrophils. J. Cell Biol. 113, 743-756.
40. Almkvist, J., Fäldt, J., Dahlgren, C., Leffler, H., Karlsson, A. (2001) Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe. Infect. Immun. 69, 832-837.
41. Nauseef, W. M., McCormick, S. J., Goedken, M. (1998) Coordinated participation of calreticulin and calnexin in the biosynthesis of myeloperoxidase. J. Biol. Chem. 273, 7107-7111.
42. Gullberg, U., Bengtsson, N., Bulow, E., Garwicz, D., Lindmark, A., Olsson, I. (1999) Processing and targeting of granule proteins in human neutrophils. J. Immunol. Methods 232, 201-210.
43. Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H. F., Leonard, E. J., Oppenheim, J. J. (1988) Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 167, 1883-1893.
44. Rose, J. J., Foley, J. F., Murphy, P. M., Venkatesan, S. (2004) On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2. J. Biol. Chem. 279, 24372-24386.
45. Reinsberg, J., Dembinski, J., Dorn, C., Behrendt, D., Bartmann, P., van Der Ven, H. (2000) Determination of total interleukin-8 in whole blood after cell lysis. Clin. Chem. 46, 1387-1394.
46. Price, B., Dennison, C., Tschesche, H., Elliott, E. (2000) Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosome. J. Biol. Chem. 275, 28308-28315.