Diltiazem, a L-type calcium channel antagonist, suppresses ouabain-enhanced dopamine efflux by 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatum

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 5, 2006, Pages 721-723

  Obata, Toshio ^a  

^a OHU UNIVERSITY   (Japan)

Author keywords

1 Methyl 4 phenylpyridinium ion (MPP+); Ca2+ overload; Diltiazem; Dopamine; Ouabain; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BAYER; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DOPAMINE; NIFEDIPINE; OUABAIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG EFFECT; EXTRACELLULAR FLUID; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CORPUS STRIATUM; DILTIAZEM; DOPAMINE; MALE; OUABAIN; RATS; RATS, WISTAR;

STROPHANTHUS GRATUS;

EID: 33646110099     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2006.01.007     Document Type: Article

References (13)

1. Miller R.J. Multiple calcium channels and neuronal function. Science 235 (1987) 46-52
2. LoPachin R.M., Gaughan C.L., Lehning E.J., Weber M.L., and Taylor C.P. Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons. Neuroscience 103 (2001) 971-983
3. 2+ channel agonists. J. Biol. Chem. 275 (2000) 41504-41511
4. 2+ influx. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 6566-6570
5. Markey S.P., Johannessen J.N., Chiueh C.C., Burns R.S., and Herkenham M.A. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 311 (1984) 464-467
6. +. J. Neural Transm. 74 (1988) 75-86
7. +) into the striatum is associated with hydroxyl free radical generation. Brain Res. 906 (2001) 170-175
8. Obata T. Dopamine efflux by MPTP and hydroxyl radical generation. J. Neural Transm. 109 (2002) 1159-1180
9. Murphy E., Jacob R., and Lieberman M. Cytosolic free calcium in chick heart cells. Its role in cell injury. J. Mol. Cell. Cardiol. 17 (1985) 221-231
10. Chiueh C.C., Wu R.-M., Mohanakumar K.P., Sternberger L.M., Krishna G., Obata T., and Murphy D.L. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Ann. N.Y. Acad. Sci. 738 (1994) 25-36
11. Paxinos G., and Watson C. The Rat Brain Stereotaxic Coordinates. 2nd ed., (1982), Academic Press, Sydney
12. + enhances potassium-evoked striatal dopamine release through a omega-conotoxin-insensitive, tetrodotoxin- and nimodipine-sensitive calcium-dependent mechanism. Ann. N.Y. Acad. Sci. 635 (1991) 393-396
13. Kitamura Y., Shimohama S., Akaike A., and Taniguchi T. The parkinsonian models: invertebrates to mammals. Jpn. J. Pharmacol. 84 (2000) 237-243