Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma

Journal of Neuroimmunology

Volumn 174, Issue 1-2, 2006, Pages 168-173

  Camdessanché, Jean Philippe ^a,b   Lassablière, François ^a   Meyronnet, David ^c   Férraud, Karine ^a   Absi, Léna ^a   Honnorat, Jérôme ^c,d   Antoine, Jean Christophe ^a,b  

^a UNIVERSITÉ JEAN MONNET   (France)

^b SERVICE DE NEUROLOGIE   (France)

^c INSERM   (France)

^d HÔPITAL NEUROLOGIQUE   (France)

Author keywords

Anti CRMP5 antibody; Anti CV2 antibody; CRMP5; Myasthenia gravis; Nerve fibers; Paraneoplastic neurological syndrome; Thymoma; Thymus

Indexed keywords

COLLAPSIN RESPONSE MEDIATOR PROTEIN; COLLAPSIN RESPONSE MEDIATOR PROTEIN 5; PROTEIN ANTIBODY; TUMOR ANTIGEN; TUMOR EXTRACT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; BRAIN; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LUNG SMALL CELL CANCER; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOMA; THYMUS; TUMOR; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BLOTTING, WESTERN; CEREBELLUM; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMOMA; THYMUS GLAND; THYMUS HYPERPLASIA;

EID: 33646096756     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.01.018     Document Type: Article

References (29)

1. Antoine J.C., Honnorat J., Vocanson C., Koenig F., Aguera M., Belin M.F., and Michel D. Posterior uveitis, paraneoplastic encephalomyelitis and auto-antibodies reacting with developmental protein of brain and retina. J. Neurol. Sci. 117 (1993) 215-223
2. Antoine J.C., Honnorat J., Anterion C.T., Aguera M., Absi L., Fournel P., and Michel D. Limbic encephalitis and immunological perturbations in two patients with thymoma. J. Neurol. Neurosurg. Psychiatry 58 (1995) 706-710
3. Artico M., Cavallotti C., and Cavallotti D. Adrenergic nerve fibres and mast cells: correlation in rat thymus. Immunol. Lett. 84 (2002) 69-76
4. Byk T., Ozon S., and Sobel A. The Ulip family phosphoproteins-common and specific properties. Eur. J. Biochem. 254 (1998) 14-24
5. Cartalat-Carel S., Camdessanche J.P., Ricard D., Ferraud K., Honnorat J., and Antoine J.C. The paraneoplastic neurological syndrome associated with anti-CV2 (anti-CRMP5) antibodies is different from that of anti-Hu antibodies. Neurology 62 (2004) A476
6. Cavallotti C., Artico M., and Cavallotti D. Occurrence of adrenergic nerve fibers and of noradrenaline in thymus gland of juvenile and aged rats. Immunol. Lett. 70 (1999) 53-62
7. Charrier E., Reibel S., Rogemond V., Aguera M., Thomasset N., and Honnorat J. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol. 28 (2003) 51-64
8. Dalmau J., Graus F., Cheung N.K., Rosenblum M.K., Ho A., Canete A., Delattre J.Y., Thompson S.J., and Posner J.B. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 75 (1995) 99-109
9. Darnell R.B. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 4529-4536
10. Darnell R.B., and Posner J.B. Paraneoplastic syndromes involving the nervous system. N. Engl. J. Med. 349 (2003) 1543-1554
11. Dovas A., Lucchi M.L., Bortolami R., Grandis A., Palladino A.R., Banelli E., Carretta M., Magni F., and Paolocci N. Collaterals of recurrent laryngeal nerve fibres innervate the thymus: a fluorescent tracer and HRP investigation of efferent vagal neurons in the rat brainstem. Brain Res. 809 (1998) 141-148
12. Downing J.E., and Miyan J.A. Neural immunoregulation: emerging roles for nerves in immune homeostasis and disease. Immunol. Today 21 (2000) 281-289
13. Flores K.G., Li J., Sempowski G.D., Haynes B.F., and Hale L.P. Analysis of the human thymic perivascular space during aging. J. Clin. Invest. 104 (1999) 1031-1039
14. Flores K.G., Li J., and Hale L.P. B cells in epithelial and perivascular compartments of human adult thymus. Human Pathol. 32 (2001) 926-934
15. Fukada M., Watakabe I., Yuasa-Kawada J., Kawachi H., Kuroiwa A., Matsuda Y., and Noda M. Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. J. Biol. Chem. 275 (2000) 37957-37965
16. Honnorat J., Byk T., Kusters I., Aguera M., Ricard D., Rogemond V., Quach T., Aunis D., Sobel A., Mattei M.G., Kolattukudy P., Belin M.F., and Antoine J.C. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur. J. Neurosci. 11 (1999) 4226-4232
17. Honnorat J., Antoine J.C., and Belin M.F. Are the "newly discovered" paraneoplastic anticollapsin response-mediator protein 5 antibodies simply anti-CV2 antibodies?. Ann. Neurol. 50 (2001) 688-691
18. Jurjus A.R., More N., and Walsh R.J. Distribution of substance P positive cells and nerve fibers in the rat thymus. J. Neuroimmunol. 90 (1998) 143-148
19. Kato S. Thymic microvascular system. Microsc. Res. Tech. 38 (1997) 287-299
20. Kuwabara H., Krenacs T., Hirano H., Nishio H., Shikata T., Kizaki T., Nagai M., Suzuki K., and Mori H. Immunolocalization of peripheral lymph node addressins in normal and neoplastic human thymuses. Appl. Immunohistochem. Mol. Morphol. 10 (2002) 253-257
21. Kyewski B., and Derbinski J. Self-representation in the thymus: an extended view. Nat. Rev., Immunol. 4 (2004) 688-698
22. Marx A., O'Connor R., Geuder K.I., Hoppe F., Schalke B., Tzartos S., Kalies I., Kirchner T., and Muller-Hermelink H.K. Characterization of a protein with an acetylcholine receptor epitope from myasthenia gravis-associated thymomas. Lab. Invest. 62 (1990) 279-286
23. Muller-Hermelink H.K., and Marx A. Thymoma. Curr. Opin. Oncol. 12 (2000) 426-433
24. Ricard D., Rogemond V., Charrier E., Aguera M., Bagnard D., Belin M.F., Thomasset N., and Honnorat J. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a-sensitive oligodendrocytes. J. Neurosci. 21 (2001) 7203-7214
25. Schultz A., Hoffacker V., Wilisch A., Nix W., Gold R., Schalke B., Tzartos S., Muller-Hermelink H.K., and Marx A. Neurofilament is an autoantigenic determinant in myasthenia gravis. Ann. Neurol. 46 (1999) 167-175
26. Strobel P., Rosenwald A., Beyersdorf N., Kerkau T., Elert O., Murumagi A., Sillanpaa N., Peterson P., Hummel V., Rieckmann P., Burek C., Schalke B., Nix W., Kiefer R., Muller-Hermelink H.K., and Marx A. Selective loss of regulatory T cells in thymomas. Ann. Neurol. 56 (2004) 901-904
27. Vincent A., and Willcox N. The role of T-cells in the initiation of autoantibody responses in thymoma patients. Pathol. Res. Pract. 195 (1999) 535-540
28. Wilisch A., Gutsche S., Hoffacker V., Schultz A., Tzartos S., Nix W., Schalke B., Schneider C., Muller-Hermelink H.K., and Marx A. Association of acetylcholine receptor alpha-subunit gene expression in mixed thymoma with myasthenia gravis. Neurology 52 (1999) 1460-1466
29. Yu Z., Kryzer T.J., Griesmann G.E., Kim K., Benarroch E.E., and Lennon V.A. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann. Neurol. 49 (2001) 146-154