Mifepristone-induced cervical ripening: Structural, biomechanical, and molecular events

American Journal of Obstetrics and Gynecology

Volumn 194, Issue 5, 2006, Pages 1391-1398

  Clark, Kelley ^a   Ji, Huiling ^b   Feltovich, Helen ^a   Janowski, Jessie ^a   Carroll, Colleen ^a   Chien, Edward K ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b WOMEN AND INFANTS HOSPITAL   (United States)

Author keywords

Cervix; Labor; Mifepristone; MMP; Pregnancy; Progesterone; Rat

Indexed keywords

COLLAGEN; COLLAGEN FIBRIL; COLLAGENASE; GELATINASE A; MATRIX METALLOPROTEINASE; MIFEPRISTONE; PROGESTERONE;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HORMONE RESPONSE; MICROSCOPY; NONHUMAN; POLARIZATION; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND TRIMESTER PREGNANCY; STRUCTURE ANALYSIS; TENSILE STRENGTH; TRANSMISSION ELECTRON MICROSCOPY; UTERINE CERVIX; UTERINE CERVIX RIPENING; WESTERN BLOTTING;

ANIMALS; CERVICAL RIPENING; CERVIX UTERI; COLLAGEN; EXTRACELLULAR MATRIX; FEMALE; GESTATIONAL AGE; HORMONE ANTAGONISTS; MATRIX METALLOPROTEINASE 2; MICROSCOPY, ELECTRON; MICROSCOPY, POLARIZATION; MIFEPRISTONE; PREGNANCY; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TENSILE STRENGTH;

EID: 33646091736     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2005.11.026     Document Type: Article

References (30)

1. Infant mortality and low birth weight among black and white infants: United States, 1980-2000. MMWR Morb Mortal Weekly Rep 51 (2002) 589-592
2. Goldenberg R.L., Iams J.D., Das A., Mercer B.M., Meis P.J., Moawad A.H., et al. The Preterm Prediction study: sequential cervical length and fetal fibronectin testing for the prediction of spontaneous preterm birth: National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obst Gynecol 182 (2000) 636-643
3. Graham J.D., and Clarke C.L. Physiological action of progesterone in target tissues. Endocr Rev 18 (1997) 502-519
4. Lopez Bernal A., Europe-Finner G.N., Phaneuf S., and Watson S.P. Preterm labour: a pharmacological challenge. Trends Pharmacol Sci 16 (1995) 129-133
5. Haluska G.J., Wells T.R., Hirst J.J., Brenner R.M., Sadowsky D.W., and Novy M.J. Progesterone receptor localization and isoforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition. J Soc Gynecol Investig 9 (2002) 125-136
6. Meis P.J., Klebanoff M., Thom E., Dombrowski M.P., Sibai B., Moawad A.H., et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. [see comment; erratum appears in N Engl J Med 2003;349:1299]. N Engl J Med 348 (2003) 2379-2385
7. Fang X., Wong S., and Mitchell B.F. Effects of RU486 on estrogen, progesterone, oxytocin, and their receptors in the rat uterus during late gestation. Endocrinology 138 (1997) 2763-2768
8. Chwalisz K., and Garfield R.E. Role of progesterone during pregnancy: models of parturition and preeclampsia. Z Geburtshilfe Perinatol 198 (1994) 170-180
9. Imada K., Sato T., Hashizume K., Tanimoto A., Sasaguri Y., and Ito A. An antiprogesterone, onapristone, enhances the gene expression of promatrix metalloproteinase 3/prostromelysin-1 in the uterine cervix of pregnant rabbit. Biol Pharm Bull 25 (2002) 1223-1227
10. Winkler M., and Rath W. Changes in the cervical extracellular matrix during pregnancy and parturition. J Perinat Med 27 (1999) 45-60
11. Woessner Jr. J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5 (1991) 2145-2154
12. Nagase H. Matrix Metalloproteinases 1, 2 and 3: substrate specificities and activation mechanisms (1991), Perinatology Press, Ithaca (NY)
13. Petrocelli T., and Lye S.J. Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone. Endocrinology 133 (1993) 284-290
14. Williams L.M., Hollingsworth M., and Dixon J.S. Changes in the tensile properties and fine structure of the rat cervix in late pregnancy and during parturition. J Reprod Fertil 66 (1982) 203-211
15. Feltovich H., Ji H., Janowski J.W., Delance N.C., Moran C.C., and Chien E.K. Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term. Am J Obst Gynecol 192 (2005) 753-760
16. Chien E.K., Ji H., Feltovich H., and Clark K. Expression of matrix metalloproteinase-3 in the rat cervix during pregnancy and in response to prostaglandin E2. Am J Obstet Gynecol 192 (2005) 309-317
17. Yu S.Y., Tozzi C.A., Babiarz J., and Leppert P.C. Collagen changes in rat cervix in pregnancy-polarized light microscopic and electron microscopic studies. Proc Soc Exper Biol Med 209 (1995) 360-368
18. Stiemer B., and Elger W. Cervical ripening of the rat in dependence on endocrine milieu; effects of antigestagens. J Perinat Med 18 (1990) 419-429
19. Challis J.R.G., Matthews S.G., Gibb W., and Lye S.J. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 21 (2000) 514-550
20. Chwalisz K. The use of progesterone antagonists for cervical ripening and as an adjunct to labour and delivery. Hum Reprod 9 suppl (1994) 131-161
21. Leppert P.C., and Yu S.Y. Apoptosis in the cervix of pregnant rats in association with cervical softening. Gynecol Obstet Investig 37 (1994) 150-154
22. Leppert P.C. Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone. Am J Obstet Gynecol 178 (1998) 713-725
23. Lavagnino M., Arnoczky S.P., Frank K., and Tian T. Collagen fibril diameter distribution does not reflect changes in the mechanical properties of in vitro stress-deprived tendons. J Biomech 38 (2005) 69-75
24. Wolf K., Sandner P., Kurtz A., and Moll W. Messenger ribonucleic acid levels of collagenase (MMP-13) and matrilysin (MMP-7) in virgin, pregnant, and postpartum uterus and cervix of rat. Endocrinology 137 (1996) 5429-5434
25. Imada K., Ito A., Sato T., Namiki M., Nagase H., and Mori Y. Hormonal regulation of matrix metalloproteinase 9/gelatinase B gene expression in rabbit uterine cervical fibroblasts. Biol Reprod 56 (1997) 575-580
26. Lenhart J.A., Ryan P.L., Ohleth K.M., Palmer S.S., and Bagnell C.A. Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig. Endocrinology 142 (2001) 3941-3949
27. Stygar D., Wang H., Vladic Y.S., Ekman G., Eriksson H., and Sahlin L. Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix. Biol Reprod 67 (2002) 889-894
28. Aimes R.T., and Quigley J.P. Matrix metalloproteinase-2 is an interstitial collagenase: inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem 270 (1995) 5872-5876
29. Deryugina E.I., Ratnikov B., Monosov E., Postnov T.I., Di Scipio R., Smith J.W., et al. MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells. Exp Cell Res 263 (2001) 209-223
30. Zhang J., Hampton A.L., Nie G., and Salamonsen L.A. Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol Reprod 62 (2000) 85-94