Statistical analysis of combined dose effects for experiments with two agents

Artificial Intelligence in Medicine

Volumn 37, Issue 1, 2006, Pages 65-71

  Wagenpfeil, Stefan ^a   Treiber, Uwe ^b   Lehmer, Antonie ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Combination index; Dose response curves; Isobolograms; Logistic regression; MATLAB implementation

Indexed keywords

COMPUTER GRAPHICS; COMPUTER SOFTWARE; DATA REDUCTION; REGRESSION ANALYSIS; STATISTICAL METHODS;

COMBINATION INDEX; DOSE-RESPONSE CURVES; ISOBOLOGRAMS; LOGISTIC REGRESSION; MATLAB IMPLEMENTATION;

DRUG DOSAGE;

ARTICLE; COMPUTER PROGRAM; DOSE RESPONSE; DRUG EFFECT; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FENRETINIDE; HUMANS; INHIBITORY CONCENTRATION 50; LOGISTIC MODELS; MALE; MODELS, STATISTICAL; PROSTATIC NEOPLASMS; SOFTWARE; TAXOIDS;

EID: 33646076482     PISSN: 09333657     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.artmed.2005.01.011     Document Type: Article

References (27)

1. Wagenpfeil S., Treiber U., and Lehmer A. A MATLAB-based software tool for changepoint detection and nonlinear regression in dose-response relationships. In: Brause R.W., and Hanisch E. (Eds). Medical data analysis, lecture notes in computer science vol. 1993 (2000), Springer-Verlag, Berlin 190-197
2. Röhm N.W., Rodgers G.H., Hatfield S.M., and Glasebook A.L. Unimproved colorimetric assay for cell proliferation and viability utilizing tetrazoliumsalt XTT. J Immunol Methods 142 (1991) 257-265
3. Wagenpfeil S., Treiber U., and Lehmer A. Isobologram analysis in MATLAB for combined effects of two agents in dose-response experiments. In: Perner P., Brause R., and Holzhütter H.-G. (Eds). Medical data analysis, lecture notes in computer science vol. 2868 (2003), Springer-Verlag, Berlin, Heidelberg, New York 47-54
4. Chuang-Stein C., and Agresti A. Tutorial in biostatistics: a review of tests for detecting a monotone dose-response relationship with ordinal response data. Stat Med 16 (1997) 2599-2618
5. Steel G.G., and Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Physiol 5 (1979) 85-91
6. Kano Y., Suzuki K., Akutsu M., Suda K., Inoue Y., Yoshida M.,., et al. Effects of CPT-11 in combination with other anti-cancer agents in culture. Int J Cancer 50 (1992) 604-610
7. Chou T.C., and Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22 (1984) 27-55
8. Holstein S.A., and Hohl R.J. Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther 1 (2001) 141-149
9. Figul M., Söling A., Dong H.J., Chou T.C., and Rainov N.G. Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells. Cancer Chemother Pharmacol 52 (2003) 41-46
10. Tallarida R.J. The interaction index: a measure of drug synergism. Pain 98 (2002) 163-168
11. Avramis I.A., Laug W.E., Sausville E.A., and Avramis V.I. Determination of drug synergism between the tyrosine kinase inhibitors NSC 680410 (adaphostin) and/or STI571 (imatinib mesylate, Gleevec) with cytotoxic drugs against human leukemia cell lines. Cancer Chemother Pharmacol 52 (2003) 307-318
12. Meco D., Colombo T., Ubezio P., Zucchetti M., Zaffaroni M., Riccardi A.,., et al. Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies. Cancer Chemother Pharmacol 52 (2003) 131-138
13. Kenett R., and Zacks S. Modern industrial statistics-the design and control of quality and reliability (1998), Duxbury Press, Pacific Grove, CA, USA
14. Wu C.F.J. Efficient sequential designs with binary data. J Am Stat Assoc 80 (1985) 974-984
15. Sitter R.R., and Forbes B.E. Optimal two-stage designs for binary response experiments. Stat Sinica 7 (1997) 941-955
16. O'Brien W.D., Simpson D.G., Frizzell L.A., and Zachary Jr. J.F. Superthreshold behavior and threshold estimates of ultrasound-induced lung hemorrhage in adult rats: role of beamwidth. IEEE Trans Ultrason, Ferroelectr Frequency Control 48 (2001) 1695-1705
17. Clyde M., Mueller P., and Parmigiani G. Optimal design for heart defibrillators. In: Gatsonis C., Hodges J.S., Kass R.E., and Singpurwalla N.D. (Eds). Bayesian statistics in science and engineering: case studies II (1995), Springer-Verlag, Berlin 278-292
18. Dette H, Neumeyer N, Pilz KF. A note on nonparametric estimation of the effective dose in quantal bioassay. Technical Report, Ruhr-Universität-Bochum. http://www.ruhr-uni-bochum.de/mathematik3/preprint.htm; 2003 (last accessed: 17 January 2005).
19. Biedermann S, Dette H, Zhu W. Optimal designs for dose-response models with restricted design spaces. Technical Report, Ruhr-Universität-Bochum. http://www.ruhr-uni-bochum.de/mathematik3/preprint.htm; 2004 (last accessed: 17 January 2005).
20. Nishizaki M., Meyn R.E., Levy L.B., Atkinson E.N., White R.A., Roth J.A.,., et al. Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo. Clin Cancer Res 7 (2001) 2887-2897
21. Kano Y., Akutsu M., Suzuki K., Mori K., Yazawa Y., and Tsunoda S. Schedule-dependent interactions between paclitaxel and etoposide in human carcinoma cell lines in vitro. Cancer Chemother Pharmacol 44 (1999) 381-388
22. Menendez J.A., Ropero S., del Barbacid M.M., Montero S., Solanas M., Escrich E.,., et al. Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. Breast Cancer Res Treat 72 (2002) 203-219
23. Tan Y.J., Teng E., and Ting A.E. A small inhibitor of the interaction between Bax and Bcl-X(L) can synergize with methylprednisolone to induce apoptosis in Bcl-X(L)-overexpressing breast-cancer cells. J Cancer Res Clin Oncol 129 (2003) 437-448
24. Vasilevskaya I.A., Rakitina T.V., and O'Dwyer P.J. Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. Cancer Res 63 (2003) 3241-3246
25. Shingu T., Yamada K., Hara N., Moritake K., Osago H., Terashima M.,., et al. Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res 63 (2003) 4044-4047
26. Coleman Th, Branch MA, Grace A. optimization toolbox for use with MATLAB, user's guide, Version 2. 3rd printing, Natick, MA 01760-1500, USA: The Math Works Inc.; 1999.
27. Luszczki J.J., and Czuczwar S.J. Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics-a comparative study. Epilepsy Res 56 (2003) 27-42