Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats

Neuroscience Letters

Volumn 399, Issue 1-2, 2006, Pages 167-170

  Xiong, Wei ^a   Yu, Long Chuan ^a  

^a National Laboratory of Biomembrane and Membrane Biotechnology   (China)

Author keywords

Antinociception; Hindpaw withdrawal latency; Morphine; Nucleus accumbens; Opioid receptor

Indexed keywords

BETA FUNALTREXAMINE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; HINDLIMB; LATENT PERIOD; MALE; MECHANICAL STIMULATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; THERMAL STIMULATION; WITHDRAWAL REFLEX;

ANALGESICS, OPIOID; ANIMALS; MALE; MORPHINE; NALOXONE; NALTREXONE; NUCLEUS ACCUMBENS; PAIN; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 33646076458     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.01.052     Document Type: Article

References (19)

1. Altier N., and Stewart J. Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions. Behav. Brain Res. 89 (1997) 151-165
2. Atweh S.F., and Kuhar M.J. Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res. 134 (1977) 393-405
3. Bodnar R.J., Glass M.J., Ragnauth A., and Cooper M.L. General, mu and kappa opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions. Brain Res. 700 (1995) 205-212
4. Fields H.L., and Basbaum A.I. Central nervous system mechanisms of pain modulation. In: Wall P.D., and Melzack R. (Eds). Textbook of Pain. fourth ed. (1999), Churchill Livingston, Edinburgh 309-329
5. Gillan M.G., and Kosterlitz H.W. Spectrum of the mu-, delta-, and kappa-binding sites in homogenates of rat brain. Br. J. Pharmacol. 77 (1982) 461-469
6. Goldstein A., and Naidu A. Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol. Pharmacol. 36 (1989) 265-272
7. Li Y., Li J.J., and Yu L.C. Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect. Brain Res. 940 (2002) 69-78
8. Li J.J., Zhou X., and Yu L.C. Involvement of neuropeptide Y and Y1 receptor in antinociception in the arcuate nucleus of hypothalamus, an immunohistochemical and pharmacological study in intact rats and rats with inflammation. Pain 118 (2005) 232-242
9. Mansour A., Khachaturian H., Lewis M.E., Akil H., and Watson S.J. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci. 7 (1987) 2445-2464
10. Millan M.J., Audinot V., Honore P., Bervoets K., Veiga S., and Brocco M. Blockade of NMDA receptors in the nucleus accumbens elicits spontaneous tail-flicks in rats. Eur. J. Pharmacol. 388 (2000) 37-47
11. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, Sydney
12. Schmidt B.L., Tambeli C.H., Levine J.D., and Gear R.W. mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. Eur. J. Neurosci. 15 (2002) 861-868
13. Tseng L.F. The Pharmacology of Opioid Peptides (1995), Harwood Academic, Singapore
14. Vaccarino A.L., Olson G.A., Olson R.D., and Kastin A.J. Endogenous opiates. Peptides 20 (1999) 1527-1574
15. Ward S.J., Portoghese P.S., and Takemori A.E. Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation. Eur. J. Pharmacol. 80 (1982) 377-384
16. Yu L.C., and Han J.S. The neural pathway from nucleus accumbens to amygdala in morphine analgesia of the rabbit. Acta Physiol. Sina. 42 (1990) 277-283
17. Yu L.C., Shi Y.S., and Han J.S. Analgesia induced by morphine administered to the nucleus accumbens was blocked by naloxone or [Met5] enkephalin antiserum injected into the periaqueductal gray of the rabbit. Sheng Li Xue Bao 39 (1987) 326-333
18. Zhou Z.F., Xuan Y.T., and Han J.S. Analgesic effect of morphine injected into habenula, nucleus accumbens or amygdala of rabbits. Zhongguo Yao Li Xue Bao 5 (1984) 150-153
19. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110