Evaluating the efficiency of using second-trimester nasal bone hypoplasia as a single or a combined marker for fetal aneuploidy

Journal of Ultrasound in Medicine

Volumn 25, Issue 4, 2006, Pages 437-441

  Odibo, Anthony O ^a,e   Sehdev, Harish M ^b   Sproat, Laura ^a   Parra, Claudia ^a   Odibo, Linda ^a   Dunn, Linda ^c   Macones, George A ^d  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENNSYLVANIA HOSPITAL   (United States)

^c Delaware Valley Nephrology and Hypertension   (United States)

^d WASHINGTON UNIVERSITY   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aneuploidy; Down syndrome; Hypoplasia; Nasal bone

Indexed keywords

BIOMARKERS; BONE; SURVEYS;

ANEUPLOIDY; DOWN SYNDROMES; HYPOPLASIA; NASAL BONE HYPOPLASIA;

BIOLOGICAL ORGANS;

ADULT; ANATOMY; ANEUPLOIDY; ARTICLE; CHOROID PLEXUS; COHORT ANALYSIS; DOWN SYNDROME; FEMALE; FEMUR; FETUS ECHOGRAPHY; FETUS MALFORMATION; FINGER MALFORMATION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HUMERUS; HYPOPLASIA; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MEASUREMENT; NASAL BONE HYPOPLASIA; NOSE MALFORMATION; PROSPECTIVE STUDY; RADIOLOGICAL PARAMETERS; SECOND TRIMESTER PREGNANCY; SENSITIVITY AND SPECIFICITY;

EID: 33646046806     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2006.25.4.437     Document Type: Article

References (15)

1. Cicero S, Curcio P, Papageorghiou A, Sonek J, Nicolaides K. Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks gestation: an observational study. Lancet 2001; 358:1665-1667.
2. Sonek JD, Nicolaides KH. Prenatal ultrasonographic diagnosis of nasal bone abnormalities in three fetuses with Down syndrome. Am J Obstet Gynecol 2002; 186:139-141.
3. Otano L, Aiello H, Igarzabal L, Matayoshi T, Gadow EC. Association between first trimester absence of fetal nasal bone on ultrasound and Down syndrome. Prenat Diagn 2002; 22:930-932.
4. Zoppi MA, Ibba RM, Axiana C, Floris M, Manca F, Monni G. Absence of fetal nasal bone and aneuploidies at first-trimester nuchal translucency in unselected pregnancies. Prenat Diagn 2003; 23:496-500.
5. Orlandi F, Bilardo CM, Campogrande M, et al. Measurement of nasal bone length at 11-14 weeks of pregnancy and its potential role in Down syndrome risk assessment. Ultrasound Obstet Gynecol 2003; 22:36-39.
6. Viora E, Masturzo B, Errante G, Sciarrone A, Bastonero S, Campogrande M. Ultrasound evaluation of fetal nasal bone at 11-14 weeks in a consecutive series of 1906 fetuses. Prenat Diagn 2003; 23:784-787.
7. Cicero S, Longo D, Rembouskos G, Sacchini C, Nicolaides KH. Absent nasal bone at 11-14 weeks' gestation and chromosomal defects. Ultrasound Obstet Gynecol 2003; 22:31-35.
8. Vintzileos A, Walters C, Yeo L. Absent nasal bone in the prenatal detection of trisomy 21 in a high-risk population. Obstet Gynecol 2003; 101:905-908.
9. Bromley B, Lieberman E, Shipp TD, Benacerraf B. Fetal nasal bone length: a marker for Down syndrome in the second trimester. J Ultrasound Med 2002; 21:1387-1394.
10. Bunduki V, Ruano R, Miguelez J, Yoshizaki CT, Kahhale S, Zugaib M. Fetal nasal bone length: reference range and clinical application in ultrasound screening for trisomy 21. Ultrasound Obstet Gynecol 2003; 21:156-160.
11. Cicero S, Sonek JD, Mckenna DS, Croom CS, Johnson L, Nicolaides KH. Nasal bone hypoplasia in trisomy 21 at 15-22 weeks' gestation. Ultrasound Obstet Gynecol 2003; 21:15-18.
12. Odibo AO, Sehdev HM, Dunn L, McDonald R, Macones GA. The association between fetal nasal bone hypoplasia and aneuploidy. Obstet Gynecol 2004; 104:1229-1233.
13. Nyberg DA, Resta RG, Luthy DA, Hickok DE, Michelle A. Humerus and femur length shortening in the detection of Down's syndrome. Am J Obstet Gynecol 1993; 168:534-538.
14. Zelop CM, Milewski E, Brault K, Benn P, Borgida AF, Egan JFX. Variation of fetal nasal bone length in second-trimester fetuses according to race and ethnicity. J Ultrasound Med 2005; 24:1487-1489.
15. Bahado-Singh RO, Oz UA, Mendilcioglu I, Mahoney MJ. The mid-trimester genetic sonogram. Semin Perinatol 2005; 29:209-214.