Relationship between Subclinical Thyroid Dysfunction and Femoral Neck Bone Mineral Density in Women

Archives of Medical Research

Volumn 37, Issue 4, 2006, Pages 511-516

  Lee, Won Young ^a   Oh, Ki Won ^b   Rhee, Eun Jung ^a   Jung, Chan Hee ^a   Kim, Sun Woo ^a   Yun, Eun Joo ^c   Tae, Hyun Jung ^d   Baek, Ki Hyun ^d   Kang, Moo Il ^d   Choi, Moon Gi ^b   Yoo, Hyung Joon ^b   Park, Sung Woo ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Department of Internal Medicine ^*  (South Korea)

^c Hallym University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Bone mineral density; Subclinical hyperthyroidism; Subclinical hypothyroidism; Subclinical thyroid dysfunction; Thyroid stimulating hormone; Women

Indexed keywords

ALKALINE PHOSPHATASE; BIOCHEMICAL MARKER; CALCIUM; CREATININE; THYROTROPIN; THYROXINE;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ANALYSIS OF VARIANCE; ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BONE DENSITY; BONE TURNOVER; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; EUTHYROIDISM; FEMALE; FEMUR NECK; HORMONE BLOOD LEVEL; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; LUMBAR SPINE; MAJOR CLINICAL STUDY; PATIENT SELECTION; POST HOC ANALYSIS; STATISTICAL SIGNIFICANCE; THYROID DISEASE; THYROTROPIN BLOOD LEVEL; URINALYSIS;

EID: 33646044357     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2005.09.009     Document Type: Article

References (30)

1. Mosekilde L., Eriksen E.F., and Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am 19 (1990) 35-63
2. Uzzan B., Campos J., Cucherat M., Nony P., Boissel J.P., and Perret G.Y. Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab 81 (1996) 4278-4289
3. Tsai K.S., Lai S.M., Huang K.M., Chieng P.U., Su C.T., and Chen F.W. Decreased bone mineral density in patients with prolonged thyrotoxicosis before and after treatment. J Formos Med Assoc 90 (1991) 250-255
4. Foldes J., Tarjan G., Szathmari M., Varga F., Krasznai I., and Horvath C. Bone mineral density in patients with endogenous subclinical hyperthyroidism: is this thyroid status a risk factor for osteoporosis?. Clin Endocrinol 39 (1993) 521-527
5. Lee M.S., Kim S.Y., Lee M.C., Cho B.Y., Lee H.K., Koh C.S., et al. Negative correlation between the change in bone mineral density and serum osteocalcin in patients with hyperthyroidism. J Clin Endocrinol Metab 70 (1990) 766-770
6. Cummings S.R., Nevitt M.C., Browner W.S., Stone K., Fox K.M., Ensrud K.E., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332 (1995) 767-773
7. Wejda B., Hintze G., Katschinski B., Olbricht T., and Benker G. Hip fractures and the thyroid: a case-control study. J Intern Med 237 (1995) 241-247
8. Vestergaard P., Rejnmark L., Weeke J., and Mosekilde L. Fracture risk in patients treated for hyperthyroidism. Thyroid 10 (2000) 341-348
9. Vestergaard P., and Mosekilde L. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid 12 (2002) 411-419
10. Mosekilde L., and Melsen F. Morphometric and dynamic studies of bone changes in hypothyroidism. Acta Pathol Microbiol Scand 86 (1978) 56-62
11. Coindre J.M., David J.P., Riviere L., Goussot J.F., Roger P., de Mascarel A., et al. Bone loss in hypothyroidism with hormone replacement. A histomorphometric study. Arch Intern Med 146 (1986) 48-53
12. Bertoli A., Fusco A., Andreoli A., Magnani A., Tulli A., Lauro D., et al. Effect of subclinical hypothyroidism and obesity on whole-body and regional bone mineral content. Horm Res 57 (2002) 79-84
13. Langdahl B.L., Loft A.G., Eriksen E.F., Mosekilde L., and Charles P. Bone mass, bone turnover, body composition, and calcium homeostasis in former hyperthyroid patients treated by combined medical therapy. Thyroid 6 (1996) 161-168
14. Langdahl B.L., Loft A.G., Eriksen E.F., Mosekilde L., and Charles P. Bone mass, bone turnover, calcium homeostasis, and body composition in surgically and radioiodine-treated former hyperthyroid patients. Thyroid 6 (1996) 169-175
15. Langdahl B.L., Loft A.G., Eriksen E.F., Mosekilde L., and Charles P. Bone mass, bone turnover and body composition in former hypothyroid patients receiving replacement therapy. Eur J Endocrinol 134 (1996) 702-709
16. Abe E., Marians R.C., Yu W., Wu X.B., Ando T., Li Y., et al. TSH is a negative regulator of skeletal remodeling. Cell 115 (2003) 151-162
17. Lehmke J., Bogner U., Felsenberg D., Peters H., and Schleusener H. Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women. Clin Endocrinol 36 (1992) 511-517
18. Faber J., and Galloe A.M. Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis. Eur J Endocrinol 130 (1994) 350-356
19. Mudde A.H., Reijnders F.J., and Kruseman A.C. Peripheral bone density in women with untreated multinodular goitre. Clin Endocrinol 37 (1992) 35-39
20. Kumeda Y., Inaba M., Tahara H., Kurioka Y., Ishikawa T., Morii H., et al. Persistent increase in bone turnover in Graves' patients with subclinical hyperthyroidism. J Clin Endocrinol Metab 85 (2000) 4157-4161
21. Mudde A.H., Houben A.J., and Nieuwenhuijzen Kruseman A.C. Bone metabolism during anti-thyroid drug treatment of endogenous subclinical hyperthyroidism. Clin Endocrinol 41 (1994) 421-424
22. Faber J., Jensen I.W., Petersen L., Nygaard B., Hegedus L., and Siersbaek-Nielsen K. Normalization of serum thyrotrophin by means of radioiodine treatment in subclinical hyperthyroidism: effect on bone loss in postmenopausal women. Clin Endocrinol 48 (1998) 285-290
23. Allain T.J., Thomas M.R., McGregor A.M., and Salisbury J.R. A histomorphometric study of bone changes in thyroid dysfunction in rats. Bone 16 (1995) 505-509
24. Paul T.L., Kerrigan J., Kelly A.M., Braverman L.E., and Baran D.T. Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. JAMA 259 (1998) 3137-3141
25. Ongphiphadhanakul B., Alex S., Braverman L.E., and Baran D.T. Excessive L-thyroxine therapy decreases femoral bone mineral densities in the male rat: effect of hypogonadism and calcitonin. J Bone Miner Res 7 (1992) 1227-1231
26. Suwanwalaikorn S., Ongphiphadhanakul B., Braverman L.E., and Baran D.T. Differential responses of femoral and vertebral bones to long-term excessive L-thyroxine administration in adult rats. Eur J Endocrinol 134 (1996) 655-659
27. Suwanwalaikorn S., Van Auken M., Kang M.I., Alex S., Braverman L.E., and Baran D.T. Site selectivity of osteoblast gene expression response to thyroid hormone localized by in situ hybridization. Am J Physiol 272 (1997) E212-E217
28. Milne M., Kang M.I., Quail J.M., and Baran D.T. Thyroid hormone excess increases insulin-like growth factor I transcripts in bone marrow cell cultures: divergent effects on vertebral and femoral cell cultures. Endocrinology 139 (1998) 2527-2534
29. Engler H., Oettli R.E., and Riesen W.F. Biochemical markers of bone turnover in patients with thyroid dysfunctions and in euthyroid controls: a cross-sectional study. Clin Chim Acta 289 (1999) 159-172
30. 3 toxicosis and its relation to the iodide status in Singapore. Aust NZ J Med 6 (1976) 311-314