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Volumn 6, Issue 6, 2006, Pages 649-651

Rapid generation of molecular complexity using "hybrid" multi-component reactions (MCRs): Application to the synthesis of α-amino nitriles and 1,2-diamines

(4) Shiers, Jason J a Clarkson, Guy J a Shipman, Michael a Hayes, Jerome F b

a UNIVERSITY OF WARWICK (United Kingdom)

b GLAXOSMITHKLINE (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE DERIVATIVE; CARBON; DIAMINE DERIVATIVE; NITRILE; PIPERIDINE DERIVATIVE;

ARTICLE; CHEMICAL BOND; COMPLEX FORMATION; HYBRID; SYNTHESIS;

EID: 33646024002 PISSN: 13597345 EISSN: None Source Type: Journal
DOI: 10.1039/b516192d Document Type: Article

Times cited : (17)

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- This assignment is based on our earlier synthesis of (+)-coniine from (S)-14 (ref. 10b), wherein hydride was observed to add to the Re face of the presumed intermediate iminium cation. Assuming cyanide attack occurs via the same Re face, the (S)-configuration is expected at C-2

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