Feline foamy virus-mediated marker gene transfer: Identification of essential genetic elements and influence of truncated and chimeric proteins

Virology

Volumn 348, Issue 1, 2006, Pages 190-199

  Bastone, Patrizia ^a   Bravo, Ignacio G ^a   Löchelt, Martin ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

cis acting element; Gene therapy; Packaging; Spumavirus; Vector

Indexed keywords

CHIMERIC PROTEIN;

5' UNTRANSLATED REGION; ARTICLE; GENE CONSTRUCT; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENE TARGETING; GENE TRANSFER; GENETIC ANALYSIS; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; SEQUENCE ANALYSIS; SIMIAN VIRUS; VACCINATION; VIRAL GENETICS; VIRUS REPLICATION;

5' UNTRANSLATED REGIONS; BETA-GALACTOSIDASE; CELL LINE; GENE TRANSFER TECHNIQUES; GENE TRANSFER, HORIZONTAL; GENES, POL; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOBLOTTING; RNA, VIRAL; SEQUENCE DELETION; SPUMAVIRUS; VIRAL PROTEINS;

FELINE FOAMY VIRUS; HUMAN SPUMARETROVIRUS; PRIMATES; SIMIAE; SIMIAN VIRUS; SPUMAVIRUS;

EID: 33646021288     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2005.12.022     Document Type: Article

References (33)

1. Alke A., Schwantes A., Zemba M., Flügel R.M., and Löchelt M. Characterization of the humoral immune response and virus replication in cats experimentally infected with feline foamy virus. Virology 275 (2000) 170-176
2. Baldwin D.N., and Linial M.L. The roles of Pol and Env in the assembly pathway of human foamy virus. J. Virol. 72 (1998) 3658-3665
3. Baldwin D.N., and Linial M.L. Proteolytic activity, the carboxy terminus of Gag, and the primer binding site are not required for Pol incorporation into foamy virus particles. J. Virol. 73 (1999) 6387-6393
4. Bastone P., and Löchelt M. Kinetics and characteristics of replication-competent revertants derived from self-inactivating foamy virus vectors. Gene Ther. 11 (2004) 465-473
5. Bodem J., Löchelt M., Winkler I., Flower R.P., Delius H., and Flügel R.M. Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses. J. Virol. 70 (1996) 9024-9027
6. Buchschacher G.L. Introduction to retroviruses and retroviral vectors. Somat. Cell Mol. Genet. 26 (2001) 1-11
7. Cullen B.R. Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46 (1986) 973-982
8. Erlwein O., Cain D., Fischer N., Rethwilm A., and McClure M.O. Identification of sites that act together to direct dimerization of human foamy virus RNA in vitro. Virology 229 (1997) 251-258
9. Erlwein O., Bieniasz P.D., and McClure M.O. Sequences in pol are required for transfer of human foamy virus-based vectors. J. Virol. 72 (1998) 5510-5516
10. Flügel R.M., and Pfrepper K.I. Proteolytic processing of foamy virus Gag and Pol proteins. Curr. Top. Microbiol. Immunol. 277 (2003) 63-88
11. Geiselhart V., Schwantes A., Bastone P., Frech M., and Löchelt M. Features of the Env leader protein and the N-terminal Gag domain of feline foamy virus important for virus morphogenesis. Virology 310 (2003) 235-244
12. Geiselhart V., Bastone P., Kempf T., Schnölzer M., and Löchelt M. Furin-mediated cleavage of the feline foamy virus Env leader protein. J. Virol. 78 (2004) 13573-13581
13. Heinkelein M., Schmidt M., Fischer N., Moebes A., Lindemann D., Enssle J., and Rethwilm A. Characterization of a cis-acting sequence in the Pol region required to transfer human foamy virus vectors. J. Virol. 72 (1998) 6307-6314
14. Heinkelein M., Thurow J., Dressler M., Imrich H., Neumann-Haefelin D., McClure M.O., and Rethwilm A. Complex effects of deletions in the 5′ untranslated region of primate foamy virus on viral gene expression and RNA packaging. J. Virol. 74 (2000) 3141-3148
15. Heinkelein M., Leurs C., Rammling M., Peters K., Hanenberg H., and Rethwilm A. Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids. J. Virol. 76 (2002) 10069-10073
16. Lindemann D., and Goepfert P.A. The foamy virus envelope glycoproteins. Curr. Top. Microbiol. Immunol. 277 (2003) 111-129
17. Linial M.L. Foamy viruses are unconventional retroviruses. J. Virol. 73 (1999) 1747-1755
18. Löchelt M. Foamy virus transactivation and gene expression. Curr. Top. Microbiol. Immunol. 277 (2003) 27-61
19. Mergia A., and Heinkelein M. Foamy virus vectors. Curr. Top. Microbiol. Immunol. 277 (2003) 131-159
20. Moebes A., Enssle J., Bieniasz P.D., Heinkelein M., Lindemann D., Bock M., McClure M.O., and Rethwilm A. Human foamy virus reverse transcription that occurs late in the viral replication cycle. J. Virol. 71 (1997) 7305-7311
21. Peters K., Wiktorowicz T., Heinkelein M., and Rethwilm A. RNA and protein requirements for incorporation of the Pol protein into foamy virus particles. J. Virol. 79 (2005) 7005-7013
22. Pfeifer A., and Verma I.M. Viral vectors and their application. In: Knipe D.M., and Howley P.M. (Eds). Virology vol. 1 (2001), Lippincott, Williams and Wilkins, Philadelphia 449-469
23. Pietschmann T., Heinkelein M., Heldmann M., Zentgraf H., Rethwilm A., and Lindemann D. Foamy virus capsids require the cognate envelope protein for particle export. J. Virol. 73 (1999) 2613-2621
24. Rethwilm A. The replication strategy of foamy viruses. Curr. Top. Microbiol. Immunol. 277 (2003) 1-26
25. Roy J., Rudolph W., Juretzek T., Gartner K., Bock M., Herchenröder O., Lindemann D., Heinkelein M., and Rethwilm A. Feline foamy virus genome and replication strategy. J. Virol. 77 (2003) 11324-11331
26. Schwantes A., Ortlepp I., and Löchelt M. Construction and functional characterization of feline foamy virus-based retroviral vectors. Virology 301 (2002) 53-63
27. Schwantes A., Truyen U., Weikel J., Weiss C., and Löchelt M. Application of chimeric feline foamy virus-based retroviral vectors for the induction of antiviral immunity in cats. J. Virol. 77 (2003) 7830-7842
28. Wagner A., Doerks A., Aboud M., Alonso A., Tokino T., Flügel R.M., and Löchelt M. Induction of cellular genes is mediated by the Bel1 transactivator in foamy virus-infected human cells. J. Virol. 74 (2000) 4441-4447
29. Wilk T., de Haas F., Wagner A., Rutten T., Fuller S., Flügel R.M., and Löchelt M. The intact retroviral Env glycoprotein of human foamy virus is a trimer. J. Virol. 74 (2000) 2885-2887
30. Winkler I., Bodem J., Haas L., Zemba M., Delius H., Flower R., Flügel R.M., and Löchelt M. Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses. J. Virol. 71 (1997) 6727-6741
31. Wu M., Chari S., Yanchis T., and Mergia A. cis-Acting sequences required for simian foamy virus type 1 vectors. J. Virol. 72 (1998) 3451-3454
32. Yu S.F., Baldwin D.N., Gwynn S.R., Yendapalli S., and Linial M.L. Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses. Science 271 (1996) 1579-1582
33. Zemba M., Alke A., Bodem J., Winkler I.G., Flower R.L., Pfrepper K., Delius H., Flügel R.M., and Löchelt M. Construction of infectious feline foamy virus genomes: cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific Env sequences. Virology 266 (2000) 150-156