Distal intramural spread of rectal cancer after preoperative radiotherapy: The results of a multicenter randomized clinical study

International Journal of Radiation Oncology Biology Physics

Volumn 65, Issue 1, 2006, Pages 182-188

  Chmielik, Ewa ^a   Bujko, Krzysztof ^b   Nasierowska Guttmejer, Anna ^b   Nowacki, Marek P ^b   Kepka, Lucyna ^b   Sopylo, Rafal ^b   Wojnar, Andrzej ^c   Majewski, Przemyslaw ^d   Sygut, Jacek ^e   Karmolinski, Andrzej ^f   Huzarski, Tomasz ^g   Wandzel, Piotr ^h  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b INSTITUTE OF ONCOLOGY   (Poland)

^c Silesian Oncological Centre   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^e Holycross Cancer Center   (Poland)

^f MEDICAL UNIVERSITY OF GDANSK   (Poland)

^g POMERANIAN MEDICAL UNIVERSITY   (Poland)

^h Oncological Hospital   (Poland)

Author keywords

Distal intramural spread; Preoperative radiotherapy; Rectal cancer

Indexed keywords

DISTAL INTRAMURAL SPREAD; PREOPERATIVE RADIOTHERAPY; RECTAL CANCER;

BIOLOGICAL ORGANS; CHEMOTHERAPY; DISEASES; DOSIMETRY; RADIOTHERAPY;

TUMORS;

FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; INTESTINE ULCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROSCOPY; MULTICENTER STUDY; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; RECTUM SURGERY; RISK ASSESSMENT; SHORT COURSE THERAPY;

ADULT; AGED; ANAL CANAL; ANTIMETABOLITES, ANTINEOPLASTIC; CHI-SQUARE DISTRIBUTION; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOPLASM, RESIDUAL; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; STATISTICS, NONPARAMETRIC;

EID: 33645999349     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.11.039     Document Type: Article

References (23)

1. Kuvshinoff B., Maghfoor I., Miedema B., et al. Distal margin requirements after preoperative chemoradiotherapy for distal rectal carcinomas. Are < or = 1 cm distal margins sufficient?. Ann Surg Oncol 8 (2000) 163-169
2. Moore H.G., Riedel E., Minsky B.D., et al. Adequacy of 1 cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy. Ann Surg Oncol 10 (2003) 80-85
3. Nelson H., Petrelli N., Carlin A., et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 93 (2001) 583-596
4. Francois Y., Nemoz C.J., Bauliex J., et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer. The Lyon R90-01 randomized trial. J Clin Oncol 17 (1999) 2396-2402
5. Bujko K., Nowacki M.P., Nasierowska-Guttmejer A., et al. Sphincter preservation following preoperative radiotherapy for rectal cancer. Report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72 (2004) 15-24
6. Kinoshita H., Watanabe T., Yanagisawa A., et al. Pathological changes of advanced lower-rectal cancer by preoperative radiotherapy. Hepatogastroenterology 51 (2004) 1362-1366
7. Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
8. Marijnen C.A.M., Peeters K.C.M.J., Putter H., et al. Long term results, toxicity and quality of life in the TME trial. Radiother Oncol 73 Suppl. 1 (2004) S127-S128
9. Bujko K., Nasierowska-Guttmejer A., Nowacki M.P., et al. Intramural distal spread of rectal cancer following preoperative radiotherapy. The results of a multicentre randomized clinical study. [Abstr]. Int J Radiat Oncol Biol Phys 57 Suppl. 2 (2003) S180
10. Shirouzu K., Isomoto H., and Kakegawa T. Distal spread of rectal cancer and optimal distal margin of resection for sphincter-preserving surgery. Cancer 76 (1995) 388-392
11. Marijnen C.A.M., Nagtegaal I.D., Kapiteijn E., et al. Radiotherapy does not compensate for positive resection margins in rectal cancer patients. Report of a multicenter randomized trial. Int J Radiat Oncol Biol Phys 55 (2003) 1311-1320
12. Marijnen C.A.M., Nagtegaal I.D., Klein Kranenbarg E., et al. No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J Clin Oncol 19 (2001) 1976-1984
13. Bujko K., Nowacki M.P., Oledzki J., et al. Sphincter preservation after short-term preoperative radiotherapy for low rectal cancer. Presentation of own data and a literature review. Acta Oncol 40 (2001) 584-592
14. Glehen O., Chapet O., Adham M., et al. Long-term results of the Lyons R90-01 randomized trial of preoperative radiotherapy with delayed surgery and its effect on sphincter-saving surgery in rectal cancer. Br J Surg 90 (2003) 996-998
15. Bedrosian I., Rodriquez-Bigas M.A., Feig B., et al. Predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma. J Gastrointest Surg 8 (2004) 56-63
16. Chari R.S., Tyler D.S., Anscher M.C., et al. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann Surg 221 (1995) 778-787
17. Hiotis S.P., Weber S.M., Cohen A.M., et al. Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer. An analysis of 488 patients. J Am Coll Surg 194 (2002) 131-135
18. Hyams D.M., Mamounas E.P., Petrelli N., et al. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum. Dis Colon Rectum 40 (1997) 131-139
19. Onaitis M.W., Noone R.B., Fields R., et al. Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Ann Surg Oncol 8 (2001) 801-806
20. Zmora O., Dasilva G.M., Gurland B., et al. Does rectal wall tumor eradication with preoperative chemoradiation permit a change in the operative strategy?. Dis Colon Rectum 47 (2004) 1607-1612
21. Suit H.D., and Gallager H.S. Intact tumor cells in irradiated tissue. Arch Pathol 78 (1964) 648-651
22. Heald R.J., Husband E.M., and Ryall R.D.H. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence?. Br J Surg 69 (1982) 613-616
23. Wang Z., Zhou Z.G., Wang C., et al. Microscopic spread of low rectal cancer in regions of mesorectum. Pathologic assessment of whole-mount sections. World J Gastroenterol 10 (2004) 2949-2953