A convenient method for estimating the quantity of drug eliminated by the routes other than hepatic metabolism and renal excretion and the fraction of drug that reaches the "first pass" after oral administration

Journal of Pharmaceutical Sciences

Volumn 95, Issue 4, 2006, Pages 828-833

  Berezhkovskiy, Leonid M ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

Drug absorption; Hepatic metabolism; Oral bioavailability; Other routes of drug elimination; Peripheral drug elimination; Renal excretion

Indexed keywords

AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG METABOLISM; EXPERIMENTAL MODEL; FIRST PASS EFFECT; INTESTINE; LIVER METABOLISM; MATHEMATICAL ANALYSIS; NONHUMAN; SYSTEMIC CIRCULATION; TECHNIQUE; URINARY EXCRETION;

EID: 33645996699     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20479     Document Type: Article

References (8)

1. Welling PG. 1997. Pharmacokinetics: Processes, mathematics, and applications. Washington, DC: ACS.
2. Laurin J, Nekka F, Donati F, Varin F. 1999. Assuming peripheral elimination: its impact on the estimation of pharmacokinetic parameters of muscle relaxants. J Pharmacokinet Biopharm 27(5):491-512.
3. Lalka D, Jusco WJ, Bardos TJ. 1975. Reaction of 2,2-dimethylaziridine- type alkylating agent in biological systems II:comparative pharmacokinetics in dogs. J Pharm Sci 64:230-235.
4. Wagner JG, DiSanto AR, Gillespie WR, Albert KS. 1981. Reversible matabolism and pharmacokinetics: Application to prednisone-prednisolone. Res Commun Chem Path and Pharmcol 32:387-405.
5. Veng-Pedersen P, Gillespie WR. 1987. Theorems and implications of a model-independent elimination/distribution functiondecomposition of linear and some nonlinear drug dispositions. III. Peripheral bioavailibility and distribution time concept applied to the evaluation of distribution kinetics. J Pharmacokinet Biopharm 15:281-304.
6. Wilkinson GR, Shand DJ. 1975. A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377-390.
7. Pang KS, Rowland M. 1977. Hepatic clearance of drugs. I. Theoretical consideration of a "well-stirred" model and a "parallel tube" model. Influence of hepatic drug flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 5:625-653.
8. Berezhkovskiy LM. 2004. Determination of volume of distribution at steady state with complete consideration of the kinetics of protein and tissue binding in linear pharmacokinetics. J Pharm Sci 93:364-374.