An immunohistochemical and ultrastructural study of pancreatic microcystic serous cyst adenoma with special reference to tumor-associated microvasculature and vascular endothelial growth factor in tumor cells

Ultrastructural Pathology

Volumn 30, Issue 1-2, 2006, Pages 119-128

  Yamazaki, Kazuto ^a   Eyden, Brian ^b  

^a SAISEIKAI CENTRAL HOSPITAL   (Japan)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Angiogenesis; Body fluid regulation; Pancreatic serous cystic adenoma; PDX 1; Renal cell carcinoma; Von Hippel Lindau disease

Indexed keywords

COLLAGEN; TRANSCRIPTION FACTOR; VASCULOTROPIN; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; TRANSACTIVATOR PROTEIN; TUMOR MARKER; VASCULAR ENDOTHELIAL GROWTH FACTOR A, HUMAN; VASCULOTROPIN A;

ADULT; AGED; BLOOD ANALYSIS; BLOOD VESSEL; CASE REPORT; CELL INFILTRATION; CONFERENCE PAPER; CYSTADENOMA; EPITHELIUM CELL; FEMALE; FIBROBLAST; GENE CONTROL; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MICROVASCULATURE; MYOFIBROBLAST; NEOVASCULARIZATION (PATHOLOGY); PANCREAS ADENOMA; PARACRINE SIGNALING; PRIORITY JOURNAL; TUMOR CELL; ULTRASTRUCTURE; VASCULARIZATION; ARTICLE; METABOLISM; MICROCIRCULATION; MIDDLE AGED; PANCREAS; PANCREAS TUMOR; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; VON HIPPEL LINDAU DISEASE;

AGED; CYSTADENOMA, SEROUS; FEMALE; HIPPEL-LINDAU DISEASE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROCIRCULATION; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PANCREAS; PANCREATIC NEOPLASMS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33645992492     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.1080/01913120500407960     Document Type: Conference Paper

References (28)

1. Alpert LC, Truong LD, Bossart MI, Spjut HJ. Microcystic adenoma (serous cystadenoma) of the pancreas. a study of 14 cases with immunohistochemical and electron-microscopic correlation. Am J Surg Pathol. 1988;12:251-263.
2. Baba M, Hirai S, Kawakami T, et al. Tumor suppresser protein VHL is induced at high cell density and mediates contact inhibition of cell growth. Oncogene. 2001;20:2727-2736.
3. Arf-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol. 2002;22:635-643.
4. Bronson RT, Strauss W, Wheeler W. Pancreatic ectasia in uremic macaques. Am J Pathol. 1982;106:342-347.
5. Robbins SL, Cotran RS, Kumar V. Robbins Pathologic Basis of Disease. ed. 6, Philadelphia: WB. Saunders; 1999.
6. Dabbs D. Diagnostic Immunohistochemistry. New York: Churchill Livingstone; 2002.
7. de Paulsen N, Brychzy A, Fournier MC, et al. Role of transforming growth factor-alpha in von Hippel-Lindau (VHL) -/- clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppresser inactivation and tumorigenesis. Proc Natl Acad Sci USA. 2001;98:1387-1392.
8. Fatyol K, Szalay AA. The p14ARF tumor suppresser protein facilitates nucleolar sequestration of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and inhibits HIF-1-mediated transcription. J Biol Chem. 2001;276:28421-28429.
9. Ghadially F. Ultrastructural Pathology of the Cell and Matrix. Boston: Butterworth-Heinemann; 1997.
10. Gilbert S. Developmental Biology. Sunderland, MA: Sinauer Associates; 2000.
11. Hamilton SR, Aaltonen LA. Pathology and Genetics of Tumors of the Digestive System. World Health Organization Classification of Tumors; Lyon, IARC Press; 2000.
12. Inoue M, Yamazaki K, Shinoda K, et al. A clinicopathologic case report on macular hole associated with von Hippel-Lindau disease: a novel ultrastructural finding of worm like, wavy tangles of filaments. Graefe's Arch Clin Exp Ophthalmol. 2004;242:881-886.
13. Ivan M, Kaellin WG, Jr. The von Hippel-Lindau tumor suppressor protein. Curr Opin Genet Dev. 2001;11:27-34.
14. Knebelmann B, Ananth S, Cohe HT, Sukhatme VP. Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res. 1998;58:226-231.
15. Kosmahl M, Wanger J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Pathol. 2004;28:339-346.
16. Mohr VH, Vortmeyer AO, Zhuang Z. Histopathology and molecular genetics of multiple cysts and microcystic (serous) adenomas of the pancreas in von Hippel-Lindau patients. Am J Pathol. 2000;157:1615-1621.
17. Moore PS, Zamboni G, Brighenti A, Lissandrini D, Antonello D, Capelli P. Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppresser gene on chromosome 10q. Am J Pathol. 2001;158:317-321.
18. Rampy BA, Waxman I, Xiao S-Y, Logrono R. Serous cyst adenoma of pancreas with papillary features: a diagnostic pitfall on fine-needle aspiration biopsy. Arch Pathol Lab Med. 2001;125:1592-1594.
19. Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 alpha. Genes Dev. 2000;14:34-44.
20. Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev. 1999;9:22-30.
21. Solcia E, Capella C, Kloppel G. Tumors of the pancreas. In: Rosai J, Sobin LH, eds. Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology; 1997.
22. Sternberg S. Histology for Pathologists. Philadelphia: Lippincott-Raven; 1976.
23. Von Hippel E. Uber eine sehr seltene erkrankung der Netzhaut: Klinische beobachtungen. Graefe's Arch Ophthalmol. 1904;59:83.
24. Warshaw AL, Compton CC, Lewanrowski K, Gardenosa G, Mueller PR. Cystic tumors of the pancreas: new clinical, radiologic, and pathologic observations in 67 patients. Ann Surg. 1990;212:432-445.
25. Wieser RJ, Faust D, Diettrich C, Oesch F. pl6lnk4a mediates contact-inhibition of growth. Oncogene. 1999;18:277-281.
26. Yamazaki K. A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto protein. J Submicrosc Cytol Pathol. 2003;35:343-349.
27. Yamazaki K. Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. Virchows Arch. 2004;445:145-153.
28. Yamazaki K. Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial-mesenchymal interactions. Virchows Arch. 2004;444:542-553.