Colonic perforation associated with leukocytoclastic vasculitis caused by Sirolimus toxicity following renal transplantation [1]

Transplant International

Volumn 19, Issue 5, 2006, Pages 430-431

  Hugl, Beate ^a   Lhotta, Karl ^b   Ensinger, Christian ^b   Cont, Micole ^b   Kafka, Reinhold ^b   Margreiter, Raimund ^b   Rosenkranz, Alexander ^b   Bonatti, Hugo ^b  

^a Universitatsklinik fur Chirurgie Innsbruck   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; MACROLIDE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PHOSPHOTRANSFERASE INHIBITOR; RAPAMYCIN; STEROID; TACROLIMUS; TARGET OF RAPAMYCIN KINASE; TARGET OF RAPAMYCIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ACNE; ADULT; CASE REPORT; CLINICAL FEATURE; COLON PERFORATION; DIARRHEA; DIGESTIVE SYSTEM ULCER; DISEASE COURSE; DRUG ABSORPTION; DRUG DOSE REDUCTION; HUMAN; KIDNEY TRANSPLANTATION; LETTER; LEUKOCYTOCLASTIC VASCULITIS; MALE; PANCYTOPENIA; PRIORITY JOURNAL; WOUND HEALING IMPAIRMENT;

ABDOMINAL INJURIES; ADULT; COLON; DRUG INTERACTIONS; FATAL OUTCOME; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MALE; SIROLIMUS; TOMOGRAPHY, X-RAY COMPUTED; VASCULITIS, HYPERSENSITIVITY;

EID: 33645988839     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2006.00276.x     Document Type: Letter

References (9)

1. Sehgal SN. Rapamune (RAPA, rapamycin, sirolismus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998 31 335.
2. Groth CG Bäckman L Morlaes JM et al. Sirolismus (rapamycin)-based therapy in human renal transplantation. Transplantation 1999 67 1036.
3. Stelzmueller I Dunst KM Hengster P et al. A cluster of rotavirus enteritis in adult transplant recipients. Transpl Int 2005 18 470.
4. Biebl M Stelzmüller I Nachbaur D Wolf D Suman G Bonatti H. Fatal clostridium difficile-associated toxic megacolon following unrelated stem-cell. Eur Surg Acta Chir Austriaca 2006 38 1 5.
5. Fiorentino DF. Cutaneous vasculitis. J Am Acad Dermatol 2003 48 311.
6. Crowe A Bruelisauer A Duerr L Guntz P Lemair M. Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats. Drug Metab Dispos 1999 27 627.
7. Hardinger KL Cornelius LA Trulock EP et al. Sirolimus-induced leukocytoclastic vasculitis. Transplantation 2002 74 739.
8. Pasqualotto AC Bianco PD Sukiennik TCT et al. Sirolimus-induced leukocytoclastic vasculitis: the second case report. Am J Transplant 2004 4 1549.
9. Nagarajan S Friedrich T Garcia M Kambham N Sarwal MM. Gastrointestinal leukocytoclastic vasculitis: an adverse effect of sirolimus. Pediatr Transplant 2005 9 97.