Mechanism of action of L-arginine on the vitality of spermatozoa is primarily through increased biosynthesis of nitric oxide

Biology of Reproduction

Volumn 74, Issue 5, 2006, Pages 954-958

  Srivastava, Sudha ^a   Desai, Prashant ^b,c   Coutinho, Evans ^b   Govil, Girjesh ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b BOMBAY COLLEGE OF PHARMACY   (India)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Nitric oxide; Sperm; Sperm capacitation; Sperm maturation; Sperm motility and transport

Indexed keywords

ARGININE; N(G) METHYLARGININE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; EPIDIDYMIS; FERTILIZATION; GOAT; MALE; MALE GENITAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; SPERM; SPERMATOZOON; SPERMATOZOON MOTILITY;

ANIMALS; ARGININE; CELL MEMBRANE; GOATS; LIPID PEROXIDATION; MALE; NITRIC OXIDE; SPERMATOZOA;

ANIMALIA; CAPRA HIRCUS;

EID: 33645986988     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.046896     Document Type: Article

References (30)

1. Adman M. Effect of arginine on oligospermia. Fertil. Steril 1970; 21:217-219.
2. Holt LE, Albanesi AA. Observation of amino acids deficiencies in man. Trans. Assoc. Am. Physicians. 1944; 58:143-156.
3. Aydin S, Inci O, Alagol B. The role of arginine indomethacin and kallikrein in the treatment of oligospermia. Int. Urol. Nephrol. 1995; 27: 199-202.
4. Scibona M, Meschini P, Capparelli S, Pecori C, Rossi P, Fabris GFM. Arginine and male infertility. Minerva Urol. Nefrol. 1994; 46:251-253.
5. Radany EW, Atherton RW, Forrester IT. Arginine uptake by rabbit spermatozoa. Arch. Biochem. Biophys. 1981; 210:770-774.
6. Patel AB, Srivastava S, Phadke RS, Govil G. Arginine activates glycolysis of goat epididymal spermatozoa: An NMR study. Biophys J. 1998; 75: 1522-1528.
7. Patel AB, Srivastava S, Phadke RS, Govil G. Arginine acts as a protective and reversal agent against glycolytic inhibitors in spermatozoa. Physiol Chem Phys Med NMR. 1999; 31:29-40.
8. Mann T, Lutwak-Mann C. In: Male reproductive function and semen Springer-Verlag Berlin Heidelberg New York 1981:213
9. Mann T, Lutwak-Mann C.In Aging gametes Ed.: R. J. Blandau Karger Basel 1975:122.
10. Govil G, Phadke RS, Srivastava S. In:Lipid soluble antioxidants: Biochemistry and clinical applications Ong ASH, Packer L, (Eds.) Birkhauser Verlag Basel/Switzerland 1992:27-46.
11. Srivastava S, Desai P, Coutinho E, Govil G. Protective effect of L-arginine against lipid peroxidation in goat epididymal spermatozoa. Physiol. Chem. Phys. & Med. NMR 2000; 32:127-135.
12. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 33:664-668.
13. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology pathophysiology and pharmacology. Pharmacol. Rev. 1992; 43:109-142.
14. White IG. Lipids and calcium uptake of sperm in relation to cold shock and preservation: a review. Reprod. Fertil. Dev. 1993; 5:639-658.
15. Beuge JA, Aust SD. Methods. Enzymol. 1978; 52:302-310.
16. Keller DW, Polakoski KL. L-arginine stimulation of human sperm motility in-vitro. Biol. Reprod. 1975; 13:154-160.
17. Zini A, De Lamirande E, Gagnon C. Low levels of nitric oxide promote human sperm capacitation in vitro. J Androl 1995; 16:424-431.
18. Herrero MB, Viggiano JM, Perez Martinez S, de Gimeno MF. Evidence that nitric oxide synthase is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa. Reprod. Fertil. Dev. 1997; 9:433-439.
19. Sengoku K, Tamate K, Yoshida T, Takaoka Y, Miyamoto T, Ishikawa M. Effects of low concentrations of nitric oxide on the zona pellucida binding ability of human spermatozoa. Fertil. Steril. 1998; 69:522-527.
20. Revelli A, Costamagna C, Moffa F, Aldieri E, Ochetti S, Bosia A, Massobrio M, Lindblom B, Ghigo D. Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa. Biol. Reprod. 2001; 64:1708-1712.
21. Sliwa L, Stochmal E. Effect of sodium nitroprusside on mouse sperm migration in vitro. Arch. Androl. 2000; 45:29-33.
22. Sharma RK, Agarwal A. Artificial stimulation of cryopreserved human spermatozoa by sodium nitroprusside 2-chloroadenosine and 2-deoxyadenosine. Eur. Urol. 1997; 32:344-352.
23. Hellstrom WJ, Bell M, Wang R, Sikka SC. Effect of sodium nitroprusside on sperm motility viability and lipid peroxidation. Fertil. Steril. 1994; 61: 1117-1122.
24. Viggiano JM, Herrero MB, Martinez SPDe, Gimeno MF. Analysis of the effect of nitric oxide synthase inhibition on mouse sperm employing a modified staining method for assessment of the acrosome reaction. J. Androl. 1996; 17:692-698.
25. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J. 1994; 298:249-58.
26. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 1990; 101:746-52.
27. Brown GC. Nitric oxide and mitochondrial respiration. Biochim. Biophys. Acta. 1999; 1411:351-369.
28. Lipton SA. Neuronal protection and destruction by NO. Cell Death Differ. 1999; 6:943-951.
29. Kisa U, Basar MM, Ferhat M, Yilmaz E, Basar H, Caglayan O, Batislam E. Testicular tissue nitric oxide and thiobarbituric acid reactive substance levels: evaluation with respect to the pathogenesis of varicocele. Urol Res. 2004; 32:196-199.
30. Kausalya S, Nath J. Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury Journal of Leukocyte Biology, 1998; 64:185-191.