Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle

Lung

Volumn 184, Issue 2, 2006, Pages 89-97

  Zhu, Shu ^a   White, Richard E ^a   Barman, Scott A ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

BKCa channels; cAMP; Forskolin; Protein kinase C; Pulmonary

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; ADENYLATE CYCLASE; CYCLIC AMP; FORSKOLIN; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C MU; PROTEIN KINASE C ZETA; ROTTLERIN; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PULMONARY ARTERY; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ACETOPHENONES; ANIMALS; BENZOPYRANS; CARBAZOLES; CYCLIC AMP; ENZYME INHIBITORS; FORSKOLIN; INDOLES; ISOENZYMES; LUNG; MALE; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 33645985134     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408-005-2567-y     Document Type: Article

References (36)

1. Allison RC, Marble KT, Hernandez EM, Townsley MI, Taylor AE (1986) Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046. Am Rev Respir Dis 134:93-100
2. Barman SA (1997) Role of calcium-activated potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin. Am J Physiol 273:L142-L147
3. Barman SA (1999) Potassium channels modulate canine pulmonary vasoreactivity to protein kinase C activation. Am J Physiol 277:L558-L565
4. Ca channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol 284:L1004-L1011
5. Ca channel activity in pulmonary arterial smooth muscle. Am J Physiol 286:L149-L155
6. Ca channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol 286:L1275-L1281
7. + channels. Am J Physiol 267:H1455-H1460
8. 2+ channel modulation by 8-bromocyclic AMP in cultured heart cells. Nat Lond 304:462-464
9. Carrier GO, Fuchs LC, Winecoff AP, Giulumar AD, White RE (1997) Nitrovasodilators relax mesenteric microvessels by cGMP-induced stimulation of Ca-activated K channels. Am J Physiol 273:H76-H84
10. Conti MA, Adelstein RS (1981) The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′,5′ cAMP-dependent protein kinase. J Biol Chem 256:3178-3181
11. + channels contribute to vascular tone. Am J Physiol 34:H1135-H1141
12. Dimitropoulou C, White RE, Fuchs LC, et al. (1999) Novel mechanism, of angiotensin II induced relaxation of rat mesenteric microvessels: activation of Ang II type 2 receptor opens BKCa channels via protein kinase C (PKC). Circulation 100 (Suppl I):18, 1-846
13. Ca) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats. Am J Physiol 282:H908-H917
14. Gschwendt M, Muller HJ, Kielbassa K, et al. (1994) Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199:93-98
15. Gschwendt M, Dieterich S, Rennecke J, et al. (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase C isozymes. FEES Lett 392:77-80
16. Guldemeester A, Stenmark KR, Brough GH, Stevens T (1999) Mechanisms regulating cAMP-mediated growth of bovine neonatal pulmonary artery smooth muscle cells. Am J Physiol 276:L1010-L1017
17. Haynes J Jr, Kithais PA, Taylor AE, Strada SJ (1991) Selective inhibition of cGMP-inhibitable cAMP phosphodiesterase decreases pulmonary vasoreactivity. Am J Physiol 261:H487-H492
18. Haynes JH, Robinson J, Saunders L, Taylor AE, Strada SJ (1992) Role of cAMP-dependent protein kinase in cAMP-mediated vasodilation. Am J Physiol 262:H511-H516
19. Hei YJ, MacDonell KL, McNeill JH, Diamond J (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol Pharmacol 39:233-238
20. Le Cras TD, Kim D, Gebb S, et al. (1999) Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat. Am J Physiol 277:L709-L718
21. Lincoln TM, Cornwell TL (1993) Intracellular cyclic GMP receptor proteins. FASEB J 7:328-338
22. + channel by cyclic AMP in cultured porcine coronary artery smooth muscle cells. Life Sci 53:1129-1135
23. Nambi P, Aiyar N, Wu HL, Crooke ST (1990) Possible involvement of protein kinase C and cyclic AMP-dependent protein kinase in the sodium fluoride-mediated inhibition of cyclic nucleotide accumulation in smooth muscle cells. Cell Signal 2:531-536
24. Nash MS, Wood JP, Osborne NN (1997) Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells. Exp Eye Res 64:249-255
25. Nelson MT, Quayle JM (1995) Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 268:C799-C822
26. Orton EC, Raffestin B, McMurtry IF (1990) Protein kinase C influences rat pulmonary vascular reactivity. Am Rev Respir Dis 141:654-658
27. Post JM, Hume JR, Archer SL, Weir EK (1992) Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol 262:C882-C890
28. Reuter H (1983) Calcium channel modulation by neurotransmitters, enzymes and drugs. Nat Lend 301:569-574
29. 2+ sensitization. Am J Physiol 268:H301-H307
30. + channel in cultured smooth muscle cells of rat aortas. Am J Physiol 255:H754-H759
31. Sakai A, Voelkel NF (1988) Dibutyryl cyclic adenosine monophosphate inhibits pulmonary vasoconstriction. Lung 166:223-231
32. Ca current of rat tail artery smooth muscle cells. Am J Physiol 276:C648-C658
33. + channels in cultured rat mesenteric artery smooth muscle cells. Biol Pharm Bull 23:1450-1454
34. Torphy TJ, (1994) β-adrenoceptors, cAMP, and airway smooth muscle relaxation: challenges to the dogma. Trends Pharmacol Sci 15:370-374
35. Ca channels through a cGMP-dependent mechanism. Circ Res 77:936-942
36. White RE, Kryman JP, El-Mowafy AM, Man G, Carrier GO (2000) cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate BK (Ca) channel activity in coronary artery smooth muscle cells. Circ Res 86:897-905