L-citrulline reduces time to exhaustion and insulin response to a graded exercise test

Medicine and Science in Sports and Exercise

Volumn 38, Issue 4, 2006, Pages 660-666

  Hickner, Robert C ^a   Tanner, Charles J ^a   Evans, Chris A ^a   Clark, Paige D ^a   Haddock, Amy ^a   Fortune, Chris ^a   Geddis, Heather ^a   Waugh, William ^a   McCammon, Michael ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Glucose; L arginine; Nitric oxide; Plasma volume; Supplementation

Indexed keywords

ARGININE; CITRULLINE; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; EXERCISE TEST; EXHAUSTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN CLEARANCE; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; LUNG GAS EXCHANGE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PANCREAS; PERIPHERAL VASCULAR DISEASE; TREADMILL;

ADOLESCENT; ADULT; ANAEROBIC THRESHOLD; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; CITRULLINE; EXERCISE TEST; FEMALE; HUMANS; INSULIN; MALE; PLASMA VOLUME;

EID: 33645972265     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.mss.0000210197.02576.da     Document Type: Article

References (32)

1. ATIYA, A., G. COHEN, L. IGNARRO, and F. C. BRUNICARDI. Nitric oxide regulates insulin secretion in the isolated perfused human pancreas via a cholinergic mechanism. Surgery 120:322-327, 1996.
2. BROZEK, J., F. GRANDE, J. T. ANDERSON, and A. KEYS. Densitometric analysis of body composition: revision of some quantitative assumptions. Ann. N.Y. Acad. Sci. 110:113-140, 1963.
3. CHIN-DUSTING, J. P., C. T. ALEXANDER, P. J. ARNOLD, W. C. HODGSON, A. S. LUX, and G. L. JENNINGS. Effects of in vivo and in vitro L-arginine supplementation on healthy human vessels. J. Cardiovasc. Pharmacol. 28:158-166, 1996.
4. COIRO, V., R. VOLPI, L. CAPRETTI, G. SPERONI, G. CAFFARRI, and P. CHIODERA. Involvement of nitric oxide in arginine, but not glucose, induced insulin secretion in normal men. Clin. Endocrinol. 46:115-119, 1997.
5. CREAGER, M. A., S. J. GALLAGHER, X. J. GIRERD, S. M. COLEMAN, V. J. DZAU, and J. P. COOKE. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90:1248-1253, 1992.
6. DILL, D. B., and D. L. COSTILL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J. Appl. Physiol. 37:247-248, 1974.
7. EKBLOM, B. Blood doping and erythropoietin. The effects of variation in hemoglobin concentration and other related factors on physical performance. Am. J. Sports Med. 24:S40-S42, 1996.
8. HARTMAN, W. J., P. M. TORRE, and R. L. PRIOR. Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. J. Nutr. 124:1950-1960, 1994.
9. HICKNER, R. C., J. S. FISHER, A. A. EHSANI, and W. M. KOHRT. Role of nitric oxide in skeletal muscle blood flow at rest and during dynamic exercise in humans. Am. J. Physiol. 273:H405-H410, 1997.
10. Deleted in proof.
11. JONES, A. M., D. P. WILKERSON, and I. T. CAMPBELL. Nitric oxide synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man. J. Physiol. (Lond.) 560:329-338, 2004.
12. KINDERMANN, W., A. SCHNABEL, W. M. SCHMITT, G. BIRO, J. CASSENS, and F. WEBER. Catecholamines, growth hormone, cortisol, insulin, and sex hormones in anaerobic and aerobic exercise. Eur. J. Appl. Physiol. Occup. Physiol. 49:389-399, 1982.
13. KINGWELL, B. A., M. FORMOSA, M. MUHLMANN, S. J. BRADLEY, and G. K. MCCONELL. Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects. Diabetes 51:2572-2580, 2002.
14. HARRIS, P. A., G. R. R. CUNNINGHAM, W. E. LAWSON, and M. L. SUMMAR. Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers. Circulation 106(suppl): II-339, 2002.
15. MCCONELL, G. K., N. N. HUYNH, R. S. LEE-YOUNG, B. J. CANNY, and G. D. WADLEY. L-arginine infusion increases glucose clearance during prolonged exercise in humans. Am. J. Physiol. Endocrinol. Metab. :00263.02005, 2005.
16. MENEGUELLO, M. O., J. R. MENDONCA, A. H. LANCHA, Jr., and L. F. COSTA ROSA. Effect of arginine, ornithine and citrulline supplementation upon performance and metabolism of trained rats. Cell Biochem. Funct. 21:85-91, 2003.
17. MOLLER, A. D., and P. O. GRANDE. Role of prostacyclin and nitric oxide in regulation of basal microvascular hydraulic permeability in cat skeletal muscle. J. Vasc. Res. 36:245-252, 1999.
18. MOMKEN, I., P. LECHENE, R. VENTURA-CLAPIER, and V. VEKSLER. Voluntary physical activity alterations in endothelial nitric oxide synthase knockout mice. Am. J. Physiol. Heart Circ. Physiol. 287:H914-H920, 2004.
19. MONCADA, S., R. M. J. PALMER, and E. A. HIGGS. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43(2):109-142, 1991.
20. NAKATA, M., and T. YADA. Endocrinology: nitric oxide-mediated insulin secretion in response to citrulline in islet beta-cells. Pancreas 27:209-213, 2003.
21. PADDON-JONES, D., E. BORSHEIM, and R. R. WOLFE. Potential ergogenic effects of arginine and creatine supplementation. J. Nutr. 134:2888S-2894S, 2004.
22. PALMER, R. M. J., D. D. REES, D. S. ASHTON, and S. MONCADA. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 153:1251-1256, 1988.
23. PLANTE, G. E., M. PERREAULT, A. LANTHIER, A. MARETTE, and P. MAHEUX. Reduction of endothelial NOS and bradykinin-induced extravasation of macromolecules in skeletal muscle of the fructose-fed rat model. Cardiovasc. Res. 59:963-970, 2003.
24. ROBERTS, C. K., R. J. BARNARD, A. JASMAN, and T. W. BALON. Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 277:E390-E394, 1999.
25. ROY, D., M. PERREAULT, and A. MARETTE. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is no dependent. Am. J. Physiol. 274:E692-E699, 1998.
26. RUMBAUT, R. E., M. K. MCKAY, and V. H. HUXLEY. Capillary hydraulic conductivity is decreased by nitric oxide synthase inhibition. Am. J. Physiol. 268:H1856-H1861, 1995.
27. SCHAEFER, A., F. PIQUARD, B. GENY, S. DOUTRELEAU, E. LAMPERT, B. METTAUER, and J. LONSDORFER. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int. J. Sports Med. 23:403-407, 2002.
28. VALLANCE, P., J. COLLIER, and S. MONCADA. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 28:997-1000, 1989.
29. VICKROY, T. W., and W. L. MALPHURS. Inhibition of nitric oxide synthase activity in cerebral cortical synaptosomes by nitric oxide donors: evidence for feedback autoregulation. Neurochem. Res. 20:299-304, 1995.
30. VINCENT, S., P. BERTHON, H. ZOUHAL, E. MOUSSA, M. CATHELINE, B. BENTUE-FERRER, and A. GRATAS-DELAMARCHE. Plasma glucose, insulin and catecholamine responses to a Wingate test in physically active women and men. Eur. J. Appl. Physiol. 91:15-21, 2004.
31. WASCHER, T. C., W. F. GRAIER, P. DITTRICH, M. A. HUSSAIN, B. BAHADORI, S. WALLNER, and H. TOPLAK. Effects of low-dose L-arginine on insulin-mediated vasodilatation and insulin sensitivity. Eur. J. Clin. Invest. 27:690-695, 1997.
32. WAUGH, W. H., C. W. DAESCHNER, 3rd, B. A. FILES, M. E. MCCONNELL, and S. E. STRANDJORD. Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results. J. Natl. Med. Assoc. 93:363-371, 2001.