Clinical course and toxicokinetic data following isolated citalopram overdose in an infant

Clinical Toxicology

Volumn 44, Issue 2, 2006, Pages 165-168

  Masullo, Lawrence ^a   Miller, Michael ^a,b   Baker, S David ^b   Bose, Sudip ^a   Levsky, Marc ^a  

^a CARL R DARNALL ARMY MEDICAL CENTER   (United States)

^b Central Texas Poison Center   (United States)

Author keywords

Antidepressant; Citalopram; Infant; Seizure; Toxicity

Indexed keywords

ACTIVATED CARBON; CITALOPRAM; FOSPHENYTOIN SODIUM; MIDAZOLAM; PHENOBARBITAL; CHARCOAL; HYPNOTIC SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR;

ARTICLE; CASE REPORT; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG OVERDOSE; ELECTROCARDIOGRAM; ENDOTRACHEAL INTUBATION; EXPERIENCE; FEMALE; HALF LIFE TIME; HEART ARRHYTHMIA; HOSPITAL DISCHARGE; HUMAN; HYPOTENSION; INFANT; INTENSIVE CARE; INTUBATION; NASOGASTRIC TUBE; NYSTAGMUS; OUTCOME ASSESSMENT; QRS COMPLEX; SEIZURE; TONIC CLONIC SEIZURE; TOXICOKINETICS; WAKEFULNESS; CHEMICALLY INDUCED DISORDER; INTOXICATION; TREATMENT OUTCOME;

CHARCOAL; CITALOPRAM; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MIDAZOLAM; OVERDOSE; SEIZURES; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 33645971924     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650500514525     Document Type: Article

References (20)

1. Mosby's Drug Consult. Citalopram Hydrobromide. Mosby, Inc. 2003.
2. Goldberg JF. New drugs in psychiatry. Emerg Med Clin N Am 2000; 18(2):211-31.
3. Barbey JT. SSRI safety in overdose. J Clin Psychiatry 1998; 59(Suppl. 15): 42-8.
4. Personne M, Sjoberg G, Persson H. Citalopram overdose - review of cases treated in Swedish hospitals. Clin Toxicol 1997; 35:237-240.
5. Glassman AH. Citalopram toxicity. Lancet 1997; 350(9080):818.
6. Kelly CA, Dhaun N, Laing WJ, Strachan FE, Good AM, Bateman DN. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol, Clin Toxicol 2004; 42(1):67-71.
7. Kelly CA. Adult respiratory distress syndrome and renal failure associated with citalopram overdose. Hum Exp Toxicol 2003; 22(2):103-5.
8. Dent LA. Citalopram-induced priapism. Pharmacotherapy 2002; 22(4):538-41.
9. Catalano G. QTc interval prolongation associated with citalopram overdose: a case report and literature review. Clin Neuropharmacol 2001; 24(3):158-62.
10. Rothenhäusler HB. Suicide attempt by pure citalopram overdose causing long-lasting severe sinus bradycardia, hypotension and syncopes: successful therapy with a temporary pacemaker. Pharmacopsychiatry 2000; 33(4):150-2.
11. Cuenca PJ, Holt KR, Hoefle JD. Seizure Secondary to Citalopram Overdose. J Emerg Med 2004 Feb; 26(2):177-81.
12. Engebretsen KM, Harris CR, Wood JE. Cardiotoxicity and late onset seizures with citalopram overdose. J Emerg Med 2003; 25(2):163-6.
13. Kragh-Sorensen P, Overo KF, Petersen OL, Jensen K, Parnas W. The kinetics of citalopram: single and multiple dose studies in man. Acta Pharmacol Toxicol 1981; 48(1):53-60.
14. Milne RJ, Goa KL. Citalopram: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 1991; 41(3):450-77.
15. Overo KF. Preliminary studies of the kinetics of citalopram in man. Eur J Clin Pharmacol 1978; 14(1):69-73.
16. Gutierrez M, Abramowitz W. Steady-state pharmacokinetics of citalopram in young and elderly subjects. Pharmacotherapy 2000; 20(12):1441-7.
17. Baettig D, Bondolfi G, Montaldi S, Amey M, Baumann P. Tricyclic antidepressant plasma levels after augmentation with citalopram: a case study. Eur J Clin Pharmacol 1993; 44(4):403-5.
18. Oyehaug E, Ostensen ET, Salvesen B. High-performance liquid chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients. J Chromatogr Jun 8 1984; 308:199-208.
19. Boeck V, Overo KF, Svendsen O. Studies on acute toxicity and drug levels of citalopram in the dog. Acta Pharmacol Toxicol 1982; 50(3):169-74.
20. Routledge PA. Pharmacokinetics in children. J Antimicrob Chemother 1994; 34:19.