Pentasaccharide enhances the inactivation of factor Xa by antithrombin by promoting the assembly of a Michaelis-type intermediate complex. Demonstration by rapid kinetic, surface plasmon resonance, and competitive binding studies

Biochemistry

Volumn 45, Issue 16, 2006, Pages 5324-5329

  Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; ENZYMES; MOLECULAR STRUCTURE; POLYSACCHARIDES; RATE CONSTANTS; SURFACE PLASMON RESONANCE;

AUTOLYSIS LOOPS; HEPARINS; PENTASACCHARIDES; SERPIN CONCENTRATIONS;

BIOCHEMISTRY;

ALANINE; ANTITHROMBIN; ARGININE; BLOOD CLOTTING FACTOR 10A; HEPARIN; MUTANT PROTEIN; PENTASACCHARIDE; SERINE PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOLYSIS; CATALYSIS; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; SURFACE PLASMON RESONANCE;

ANTITHROMBINS; ARGININE; BINDING, COMPETITIVE; CELL LINE; ENZYME ACTIVATION; FACTOR XA; HEPARIN; HUMANS; KINETICS; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; SURFACE PLASMON RESONANCE; TIME FACTORS;

EID: 33645965879     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060056r     Document Type: Article

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