Fecal elastase-1: Utility in pancreatic function in cystic fibrosis

Journal of Cystic Fibrosis

Volumn 5, Issue 2, 2006, Pages 71-76

  Daftary, Ameet ^a   Acton, James ^a   Heubi, James ^a   Amin, Raouf ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cystic elastase fecal fibrosis

Indexed keywords

CHYMOTRYPSIN; ELASTASE; ELASTASE I; UNCLASSIFIED DRUG;

COST EFFECTIVENESS ANALYSIS; CYSTIC FIBROSIS; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; FOLLOW UP; GENOTYPE PHENOTYPE CORRELATION; HUMAN; LONGITUDINAL STUDY; PANCREAS FUNCTION; PANCREAS FUNCTION TEST; REFERENCE VALUE; REVIEW; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

BIOLOGICAL MARKERS; CARRIER PROTEINS; CYSTIC FIBROSIS; ENZYME TESTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXOCRINE PANCREATIC INSUFFICIENCY; FECES; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 33645965850     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2006.01.005     Document Type: Review

References (40)

1. Morral N., Bertranpetit J., Estivill X., Nunes V., Casals T., Gimenez J., et al. The origin of the major cystic fibrosis mutation (DeltaF508) in European populations. Nat Genet 7 2 (1994) 169-175
2. Durno C., Corey M., Zielenski J., Tullis E., Tsui L., and Durie P. Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterol 123 (2002) 1857-1864
3. Gaskin K., Gurwitz D., Durie P., Corey M., Levison H., and Forstner G. Improved respiratory prognosis in patients with cystic fibrosis with normal fat absorption. J Pediatr 100 (1982) 857-862
4. Kraemer R., Rudeberg A., Hadorn B., and Rossi E. Relative underweight in cystic fibrosis patients and its prognostic value. Acta Pediatr Scand 67 (1978) 33-37
5. Cystic Fibrosis Foundation: Patient Registry Annual Data Report 2003.
6. Walkowiak J., Nousia-Arvanitakis S., Henker J., Stern S., Sinaasappel M., and Dodge J.A. Indirect pancreatic function tests in children. J Pediatr Gastroenterol Nutr 40 2 (2005) 107-114
7. Balo J., and Banga J. The elastolytic activity of pancreatic extracts. Biochem J 46 (1950) 384-387
8. Sziegoleit A. A novel proteinase from human pancreas. Biochem J 219 (1984) 735
9. Sziegoleit A., and Linder D. Studies on the sterol-binding capacity of human pancreatic elastase. Gastroenterology 100 (1991) 768
10. Stein J., Jung M., Sziegoleit A., Zeuzem, Caspary W.F., and Lembcke B. Immunoreactive elastase-1: clinical evaluation of a new noninvasive test of pancreatic function. Clin Chem 42 (1996) 222-226
11. Loser C., Mollgaard A., and Folsch U.R. Faecal elastase 1: a novel highly sensitive, and specific tubeless pancreatic function test. Gut 39 (1996) 580-586
12. Dominici R., and Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med 40 4 (2002) 325-332
13. Soldan W., Henker V., and Sprossig C. Sensitivity and specificity of quantitative determination of pancreatic elastase 1 in feces of children. J Pediatr Gastroenterol Nutr 24 1 (1997) 53-55
14. Walkowiak J., Cichy W.K., and Herzig K.H. Comparison of the fecal elastase-1 determination with the secretin cholecystokinin test in cystic fibrosis patients. Scand J Gastroenterol 34 2 (1999) 202-207
15. Phillips I.J., Rowe D.J., Dewar P., and Connett G.J. Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis. Ann Clin Biochem 36 Pt6 (1999) 739-742
16. Hamwi A., Vietl M., Maenner G., Vogelsang H., and Szekeres T. Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day. Wein Klin Wochenschr 112 1 (2000) 32-35
17. Meyts I., Wuyts W., Proesmans M., and De Boeck K. Variability of fecal pancreatic elastase measurements in cystic fibrosis patients. J Cyst Fibros 1 4 (Dec 2002) 265-268
18. Miendje Y., Maisin D., Sipewa M.J., Deprez P., Buts J.P., De Nayer P., et al. Polyclonal versus monoclonal ELISA for the determination of fecal elastase 1: diagnostic value in cystic fibrosis and chronic pancreatic insufficiency. Clin Lab 50 7-8 (2004) 419-424
19. Hardt P.D., Hauenschild A., Nalop J., Marzeion A.M., Porsch-Ozcurumez M., Luley C., et al. The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency. Z Gastroenterol 41 9 (Sep 2003) 903-906
20. Pezzilli R., Morselli-Labate A.M., Palladoro F., Campana D., Piscitelli L., Tomassetti P., et al. The ELISA fecal elastase-1 polyclonal assay reacts with different antigens than those of the monoclonal assay. Pancreas 31 2 (Aug 2005) 200-201
21. Schappi M.G., Smith V.V., Cubitt D., Milla P.J., and Lindley K.J. Faecal elastase-1 concentration is a marker of duodenal enteropathy. Arch Dis Child 85 (2002) 50-53
22. Gomez J., Moran C.E., Maurino E.C., and Bai J.C. Exocrine pancreatic insufficiency in celiac disease. Gastroenterology 114 (1998) 621-623
23. Nousia-Arvanitakis S., Karagiozoglou-Lamboudes T., Aggouridaki C., Malaka-Lambrellis E., Galli-Tsinopoulou A., Xefteri M., et al. Influence of jejunal morphology changes on exocrine pancreatic function in celiac disease. J Pediatr Gastroenterol Nutr 29 (1999) 81-85
24. Walkowiak J., and Herzig K.H. Fecal elastase-1 is decreased in villous atrophy regardless of underlying disease. Eur J Clin Invest 31 (2001) 425-430
25. Salvatore S., Finazzi S., Barassi A., Verzelletti M., Tosi A., Melzi E., et al. Low fecal elastase may be related to transient small bowel damage resulting from enteric pathogens. J Pediatr Gastroenterol Nutr 36 3 (2003) 392-396
26. Masoero G., Zaffino C., Laudi C., Lombardo L., Rocca R., and Gallo L. Fecal pancreatic elastase 1 in the work up of patients with chronic diarrhea. Int J Pancreatol 28 3 (2000) 175-179
27. Beharry S., Ellis L., Corey M., Marcon M., and Durie P. How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?. J Pediatr 141 (Jul 2002) 84-90
28. Walkowiak J. Faecal elastase-1: clinical value in the assessment of exocrine pancreatic function in children. Eur J Pediatr 159 11 (2000) 869-870
29. Cade A., Walters M.P., McGinley N., Firth J., Brownlee K.G., Conway S.P., et al. Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis. Pediatr Pulmonol 29 3 (2000) 172-176
30. Walkowiak J., Nousia-Arvanitakis S., Cade A., Kashirskaya N., Piotrowski R., Strzykala K., et al. Fecal elastase-1 cut-off levels in assessment of exocrine pancreatic function in cystic fibrosis. J Cyst Fibros 1 4 (2002) 260-264
31. Nissler K., Von Katte I., Huebner A., and Henker J. Pancreatic elastase 1 in feces of preterm and term infants. J Pediatr Gastoenterol Nutr 33 1 (2001) 28-31
32. Walkowiak J., Herzig K.H., Witt M., Pogorzelski A., Piotrowski R., Barra E., et al. Analysis of exocrine pancreatic function in cystic fibrosis: one mild CFTR mutation does not exclude pancreatic insufficiency. Eur J Clin Invest 31 9 (2001) 796-801
33. Carroccio A., Verghi F., Santini B., Lucidi V., Iacono G., Cavataio F., et al. Diagnostic accuracy of fecal elastase 1 assay in patients with pancreatic maldigestion or intestinal malabsorption: a collaborative study of the Italian Society of Pediatric Gastroenterology and Hepatology. Dig Dis Sci 46 (2001) 1335-1342
34. Walkowiak J., Herzig K.H., Strzykala K., Przyslawski J., and Krawczynski M. Fecal elastase 1 is superior to fecal chymotrypsin in the assessment of pancreatic involvement in cystic fibrosis. Pediatrics 110 1 Pt 1 (2002) e7
35. Brown G.A., Sule D., Williams J., Puntis J.W.L., Booth I.W., and McNeish A.S. Fecal chymotrypsin: a reliable index of exocrine function. Arch Dis Child 63 (1988) 785-789
36. Walkowiak J., Sands D., Nowakowska A., Piotrowski R., Zybert K., Herzig K.H., et al. Early decline of pancreatic function in cystic fibrosis patients with class 1 or 2 CFTR mutations. J Pediatr Gastroenterol Nutr 40 2 (2005) 199-201
37. Leus J., Van Biervliet S., and Robberecht E. Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review. Eur J Pediatr 159 (2000) 563-568
38. Borowitz D., Baker S., Duffy L., Baker R., Fitzpatrick L., Gyamfi J., et al. Use of fecal elastase 1 to classify pancreatic status in patients with cystic fibrosis. J Pediatr 145 3 (2004) 322-326
39. Cohen J.R., Schall J.I., Ittenbach R.F., Zemel B.F., and Stallings V.A. Fecal elastase: pancreatic status verification and influence on nutritional status in children with cystic fibrosis. J Pediatr Gastroenterol Nutr 40 4 (2005) 438-444
40. Lieu T.A., Thomas Ray G., Farmer G., and Shay G.F. The cost of medical care for patients with cystic fibrosis in a health maintenance organization. Pediatrics 103 6 (1999) e72