Hepatitis C virus carriers with persistently normal ALT levels: Biological peculiarities and update of the natural history of liver disease at 10 years

Journal of Viral Hepatitis

Volumn 13, Issue 5, 2006, Pages 290-296

  Persico, M ^a,e   Perrotta, S ^b   Persico, E ^a   Terracciano, L ^c   Folgori, A ^d   Ruggeri, L ^d   Nicosia, A ^d   Vecchione, R ^c   Mura, V L ^a   Masarone, M ^a   Torella, R ^a  

^a Campus Bio Medico University   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d IRBM   (Italy)

^e NONE   (Italy)

Author keywords

HCV normal ALT; Natural history; PCNA; PNAL

Indexed keywords

ALANINE AMINOTRANSFERASE; CYCLINE; EPITOPE; GAMMA INTERFERON;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; EPIDEMIOLOGICAL DATA; FEMALE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CIRRHOSIS; MALE; PRIORITY JOURNAL; PROLIFERATING HEPATOCYTE ACTIVITY; STATISTICAL SIGNIFICANCE; VIRUS CARRIER; VIRUS GENOME;

EID: 33645963163     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2005.00667.x     Document Type: Article

References (24)

1. Persico M Persico E Suozzo R et al. Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels Gastroenterology 2000 118 760 764
2. Martinot-Peignoux M Boyer N Cazals-Hatem D et al. Prospective study of anti-hepatitis C virus-positive patients with persistently normal serum ALT with or without detectable serum HCV RNA Hepatology 2001 34 1000 1005
3. Esteban JI Lopez-Talavera JC Genesca J et al. High rate of infectivity and liver disease in blood donors with antibodies to hepatitis C virus Ann Intern Med 1991 115 443 449
4. EASL International Consensus Conference on Hepatitis C: Consensus Statement J Hepatol 1999 30 956 961
5. Puoti C Guido M Mangia A et al. (Committee on HCV carriers with normal alanine aminotransferase levels of the Italian Association for The Study of the Liver) Clinical management of HCV carriers with normal aminotransferase levels Dig Liver Dis 2003 35 362 369
6. Zeuzem S Diago M Gane E et al. International, multicenter, randomized, controlled study for the treatment of patients with chronic hepatitis C and persistently normal ALT levels with PegInterferon Ala-2a (40 Kd) (Pegasys) and Ribavirin (copegus) Hepatology 2003 38 4 106
7. Shindo M Arai K Sokawa Y et al. The virological and histological states of anti-hepatitis C virus-positive subjects with normal liver biochemical values Hepatology 1995 22 418 425
8. Puoti C Castellacci R Montagnese F et al. Histological and virological features and follow-up of HCV carriers with normal aminotransferase levels: the Italian Study of the Asymptomatic C Carriers (ISACC) J Hepatol 2002 37 1 117 123
9. Delhaye M Louis H Degraef C et al. Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis Hepatology 1996 23 1003 1011
10. Chomczynsky P Sacchi N Single step method of RNA isolation by acid guanidimum thiocyanate-phenol-chloroform extraction Anal Biochem 1987 162 156 159
11. Kwok S Higuchi R Avoiding false positives with PCR Nature 1989 339 237 238
12. Viazov S Zibert A Ramakrishnan K et al. Typing of hepatitis C virus isolates by DNA enzyme immunoassay J Virol Meth 1994 48 81 92
13. Ishak K Baptista A Bianchi L et al. Histological grading and staging of chronic hepatitis J Hepatol 1995 22 696 699
14. Takamizawa A Mori C Fuke I et al. Structure and organization of the hepatitis C virus genome isolated from human carriers J Virol 1991 65 1105 1111
15. Atherton E Hubscher W Sheppard RC Woolley V Synthesis of a 21-residue fragment of human proinsulin by the polyamide solid phase method Hoppe Seylers Z Physiol Chem 1981 362 833 839
16. Nakamura T Hayama M Sakai T Hotchi M Tanaka E Proliferative activity of hepatocytes in chronic viral hepatitis as revealed by immunohistochemistry for proliferating cell nuclear antigen Hum Pathol 1993 24 750 753
17. Donato MF Arosio E Del Ninno E et al. High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity Hepatology 2001 34 523 528
18. Gerlach JT Diepolder HM Jung MC et al. Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C Gastroenterology 1999 117 933 941
19. Grüner NH Gerlach TJ Jung MC et al. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C J Infect Dis 2000 181 1528 1536
20. Cooper S Erickson AL Adams EJ et al. Analysis of a successful immune response against hepatitis C virus Immunity 1999 10 439 449
21. Nelson DR Marousis CG Davis GL et al. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C J Immunol 1997 158 1473 1481
22. Einav S Koziel MJ Immunopathogenesis of hepatitis C virus in the immunosuppressed host Transplant Infect Dis 2002 4 85 92
23. Koziel MJ Dudley D Wong JT et al. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis J Immunol 1992 149 3339 3344
24. Rico MA Quiroga JA Subira D et al. Features of the CD4+ T cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels J Hepatol 2002 36 408 416