Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats

Food and Chemical Toxicology

Volumn 44, Issue 6, 2006, Pages 747-757

  Collins, Thomas F X ^a   Sprando, Robert L ^a   Black, Thomas N ^a   Olejnik, Nicholas ^a   Eppley, Robert M ^a   Hines, Fred A ^a   Rorie, James ^a   Ruggles, Dennis I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Deoxynivalenol; Developmental toxicity; Rat; Trichothecene mycotoxin; Vomitoxin

Indexed keywords

VOMITOXIN;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CESAREAN SECTION; CORRELATION ANALYSIS; CROWN RUMP LENGTH; CYTOPLASM; DEVELOPMENTAL DISORDER; FEMALE; FETUS DEVELOPMENT; FOOD INTAKE; GESTATION PERIOD; LIVER CELL; LIVER WEIGHT; METACARPAL BONE; METATARSAL BONE; NONHUMAN; OSSIFICATION; RAT; RAT STRAIN; SALIVATION; UTERUS WEIGHT; VERTEBRA; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; BONE AND BONES; CROWN-RUMP LENGTH; FEMALE; FETAL DEATH; FETAL DEVELOPMENT; FETAL RESORPTION; FETAL WEIGHT; LIVER; ORGAN SIZE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SALIVATION; TRICHOTHECENES; UTERUS;

EID: 33645925367     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.10.007     Document Type: Article

References (48)

1. Abouzied M.M., Azcona J.I., Braselton W.E., and Pestka J.J. Immunochemical assessment of mycotoxins in 1989 grain foods: evidence for deoxynivalenol (VT) contamination. Applied Environmental Microbiology 57 (1991) 672-677
2. Briggs G.B., and Oehme F.W. In: Baker H.J., Lindsey J.R., and Weisbroth S.H. (Eds). Toxicology The Laboratory Rat, vol. II, Research Applications (1980), Academic, New York 106
3. Brumley W.C., Trucksess M.W., Adler S.H., Cohen C.K., White K.D., and Sphon J.A. Negative ion chemical ionization mass spectrometry of deoxynivalenol (DON): application to identification of DON in grains and snack foods after quantitation/isolation by thin layer chromatography. Journal of Agricultural and Food Chemistry 33 (1985) 326-339
4. Collins T.F.X., Sprando R.L., Black T.N., Shackelford M.E., LaBorde J.B., Hansen D.K., Eppley R.M., Trucksess M.W., Howard P.C., Bryant M.A., Ruggles D.I., Olejnik N., and Rorie J.I. Effect of fumonisin B1 in pregnant rats. Part 2. Food and Chemical Toxicology 36 (1998) 673-685
5. Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicology Letters 127 1-3 (2002) 19-28
6. Daston G.P. Relationships between maternal and developmental toxicity. In: Kimmel C.A., and Buelke-Sam J. (Eds). Developmental Toxicology. second ed. (1994), Raven, New York 189-212
7. Dawson A.B. A note on the staining of the skeleton of cleared specimens with Alizarin Red S. Stain Technology 1 (1926) 123-124
8. Debouck C., Haubruge E., Bollaerts P., van Bignoot D., Brostaux Y., Werry A., and Rooze M. Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice. International Orthropaedics 25 3 (2001) 194-198
9. Eriksen G.S., and Alexander J. Fusarium toxins in cereals-a risk assessment. Nordic Council of Ministers: TemaNord 1998 502 (1998) 7-27 and 45-58 (Copenhagen)
10. FDA CFSAN Redbook, 2000. Toxicological Principles for the Safety Assessment of Food Ingredients. Section 9b. Available online at the FDA CFSAN website.
11. Forsell J.H., Witt M.F., Tai J.H., Jensen R., and Pestka J.J. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food and Chemical Toxicology 24 3 (1986) 213-219
12. Forsell J.H., Jensen R., Tai J.H., Witt M., Lin W.S., and Pestka J.J. Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. Food and Chemical Toxicology 25 2 (1987) 155-162
13. Forsyth D.M., Yoshizawa T., Morooka N., and Tuite J. Emetic and refusal activity of deoxynivalenol in swine. Applied Environmental Microbiology 34 5 (1977) 547-552
14. Hood R.D. A perspective on the significance of maternally mediated developmental toxicity. Regulatory Toxicology and Pharmacology 10 2 (1989) 144-148
15. Hood R.D., and Miller D.B. Maternally mediated effects on development. In: Hood R.D. (Ed). Developmental and Reproductive Toxicology, A Practical Approach. second ed. (2005), Taylor and Francis, Boca Raton 93-124
16. ILSI (International Life Sciences Institute), 2004. Trichothecenes with a Special Focus on DON. Summary Report of a Workshop Held in September 2003. ILSI Europe, Brussels, Belgium, pp. 1-36.
17. Khera K.S. Maternal toxicity: a possible factor in fetal malformations in mice. Teratology 29 (1984) 411-416
18. Khera K.S. Maternal toxicity: a possible etiological factor in embryo-fetal deaths and fetal malformations of rodent-rabbit species. Teratology 31 (1985) 129-153
19. Khera K.S. Maternal toxicity in humans and animals: effects on fetal development and criteria for detection. Teratogenesis, Carcinogenesis, Mutagenesis 7 3 (1987) 287-295
20. Khera K.S., Whalen C., Angers G., Vesonder R.F., and Kuiper-Goodman T. Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice. Bulletin of Environmental Contamination and Toxicology 29 4 (1982) 487-491
21. Khera K.S., Arnold D.L., Whalen C., Angers G., and Scott P.M. Vomitoxin (4-deoxynivalenol): effects on reproduction of mice and rats. Toxicology and Applied Pharmacology 74 3 (1984) 345-356
22. Khera K.S., Whalen C., and Angers G. A teratology study on vomitoxin (4-deoxynivalenol) in rabbits. Food and Chemical Toxicology 24 5 (1986) 421-424
23. Lake B.G., Phillips J.C., Walters D.G., Bayley D.L., Cook M.W., Thomas L.V., Gilbert J., Startin J.R., Baldwin N.C.P., Bycroft B.W., and Dewick P.M. Studies on the metabolism of deoxynivalenol in the rat. Food and Chemical Toxicology 25 8 (1987) 589-592
24. Luo Y. Fusarium toxins contamination of cereals in China. Proceedings of the Seventh IUPAC Symposium. In: Aibara K., Kumagai S., Ohtsubo K., and Yoshizawa R. (Eds). Mycotoxins and Phycotoxins (1988), Japanese Association of Mytoxicology 97-98
25. Marpegan M.R., Perfumo C.J., Godoy H.M., Sala de Miguel M., Diaz E., and Risso M.E. Feed refusal of pigs caused by Fusarium mycotoxins in Argentina. Journal of Veterinary Medicine A35 (1988) 610-616
26. MARTA (Mid-Atlantic Reproduction and Teratology Association) Glossary Committee, 1986. A Compilation of Terms Used in Developmental Toxicity Evaluations.
27. Morrissey R.E. Teratological study of Fischer rats fed diet containing added vomitoxin. Food and Chemical Toxicology 22 6 (1984) 453-457
28. Morrissey R.E., and Vesonder R.F. Effect of deoxynivalenol (vomitoxin) on fertility, pregnancy, and postnatal development of Sprague-Dawley rats. Applied and Environmental Microbiology 49 5 (1985) 1062-1066
29. Morrissey R.E., Norred W.P., and Vesonder R.F. Subchronic toxicity of vomitoxin in Sprague-Dawley rats. Food and Chemical Toxicology 23 11 (1985) 995-999
30. Muller H.M., and Schwadorf K. A survey of the natural occurrence of Fusarium toxins in wheat grown in a southwestern area of Germany. Mycopathologia 121 (1993) 115-121
31. National Research Council Institute of Laboratory Animal Resources. Guide for the Care and Use of Laboratory Animals (1996), National Academy Press, Washington, DC
32. Peng A., Yang C., Rui H., and Li H. Study on the pathogenic factors of Kashin-Beck disease. Journal of Toxicology and Environmental Health 35 (1992) 79-90
33. Pestka J.J., Tai J.H., Witt M.F., Dixon D.E., and Forsell J.H. Suppression of immune response in the B6C3F mouse after dietary exposure to the Fusarium mycotoxin deoxynivalenol (vomitoxin) and zearalenone. Food and Chemical Toxicology 25 4 (1987) 297-304
34. Rotter B.A., Prelusky D.B., and Pestka J.J. Toxicology of deoxynivalenol (vomitoxin). Journal of Toxicology and Environmental Health 48 (1996) 1-34
35. Schardein J.L. Approaches to defining the relationship of maternal and developmental toxicity. Teratogenesis, Carcinogenesis, Mutagenesis 7 3 (1987) 255-271
36. Shotwell O.L., Bennett G.A., Stubblefield R.D., Shannon G.M., Kwolek W.F., and Plattner R.D. Deoxynivalenol in hard red winter wheat: relationship between toxin levels and factors that could be used in grading. Journal of the Association of Official Analytical Chemists International 68 (1985) 954-957
37. Thiel P.G., Marasas W.F.O., and Meyer C.J. Natural occurrence of Fusarium toxins in maize from Transkei. Proceedings of the Fifth International IUPAC Symposium. In: Pfannhauser W.L., and Wannemacher Jr. R.W. (Eds). Mycotoxins and Phycotoxins (1982), Austrian Chemical Society 126-129
38. Trucksess M.W., Thomas F., Young K., Stack M.E., Fulgueras W.J., and Page S.W. Survey of deoxynivalenol in US 1993 wheat and barley crops by enzyme-linked immunosorbent assay. Journal of the Association of Official Analytical Chemists International 78 3 (1995) 631-636
39. Trucksess M.W., Page S.W., Wood G.E., and Cho T.-H. Determination of deoxynivalenol in white flour, whole wheat flour, and bran by solid-phase extraction/liquid chromatography: interlaboratory study. Journal of the Official Analytical Chemists International 81 4 (1998) 880-886
40. Tutel'ian V.A., Krinitskaia N.A., Avren'eva L.I., Kuz'mina E.E., Levitskaia A.B., and Kravchenko L.V. Embryonic effects of deoxynivalenol mycotoxin (vomitoxin) in rats. Gigiena I Sanitariya 10 (1991) 49-51 (in Russian)
41. Ueno Y. General toxicology. In: Ueno Y. (Ed). Developments in Food Science, IV. Trichothecenes, Chemical, Biological and Toxicological Aspects (1983), Elsevier, New York 135-146
42. Ueno Y. Trichothecene mycotoxins: mycology, chemistry, and toxicology. Advances in Nutrition Research 3 (1989) 301-353
43. Vesonder R.F., Ciegler A., Jensen A.H., Rohwedder W.K., and Weisleder D. Co-identity of the refusal and emetic principle from Fusarium-infected corn. Applied Environmental Microbiology 31 2 (1976) 280-285
44. Wannemacher Jr. R.W., Brunner D.L., and Neufeld H.A. Toxicity of trichothecene and other related mycotoxins in laboratory animals. In: Smith J.E., and Henderson R.S. (Eds). Mycotoxins and Animal Foods (1991), CRC Press, Boca Raton 499-552
45. WHO (World Health Organization), 2002. Deoxynivalenol. In: Evaluation of certain mycotoxins in food. WHO Technical Report Series 906. WHO, Geneva, Section 3.4.1, pp. 35-42.
46. Wilson J.G. Methods for administering agents and detecting malformations in experimental animals. In: Wilson J.G., and Warkany J. (Eds). Teratology: Principles and Techniques (1965), University of Chicago Press, Chicago 262-277
47. Wolf-Hall C.E., Hanna M.A., and Bullerman L.B. Stability of deoxynivalenol in heat-treated foods. Journal of Food Protection 62 8 (1999) 962-964
48. Wood G.E., and Carter L. Limited survey of deoxynivalenol in wheat and corn in the US. Journal of the Association of Official Analytical Chemists 72 (1989) 38-40