Alkalosis increases muscle K+ release, but lowers plasma [K+] and delays fatigue during dynamic forearm exercise

Journal of Physiology

Volumn 570, Issue 1, 2006, Pages 185-205

  Sostaric, Simon M ^a   Skinner, Sandford L ^b   Brown, Malcolm J ^c   Sangkabutra, Termboon ^a   Medved, Ivan ^a   Medley, Tanya ^a   Selig, Steve E ^a   Fairweather, Ian ^a   Rutar, Danny ^a   McKenna, Michael J ^a  

^a VICTORIA UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c AUSTIN HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BICARBONATE; CARBON DIOXIDE; CHLORIDE ION; ELECTROLYTE; LACTIC ACID; POTASSIUM ION; SODIUM ION; CATECHOLAMINE;

ACID BASE BALANCE; ADULT; ALKALOSIS; ARM EXERCISE; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CARBON DIOXIDE BLOOD LEVEL; CELL MEMBRANE DEPOLARIZATION; CHLORIDE TRANSPORT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DYNAMIC EXERCISE; ELECTROLYTE BLOOD LEVEL; FEMALE; FOREARM; GAS EXCHANGE; HAND FUNCTION; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE FATIGUE; MUSCLE LEVEL; NORMAL HUMAN; POTASSIUM BLOOD LEVEL; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; SODIUM TRANSPORT; TIME; VENOUS BLOOD; BLOOD CARBON DIOXIDE TENSION; BLOOD OXYGEN TENSION; CATECHOLAMINE BLOOD LEVEL; ENZYME ACTIVITY; EXERCISE INTENSITY; FATIGUE; FINGER; MEMBRANE DEPOLARIZATION; REST; YOUNG ADULT;

ALKALOSIS; CHLORIDES; EXERCISE; EXERCISE TEST; FEMALE; FOREARM; HUMANS; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; POTASSIUM; SODIUM; TIME FACTORS;

EID: 33645913826     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.094615     Document Type: Article

References (70)

1. + in frog skeletal muscle. J Appl Physiol 81, 679-685.
2. Bangsbo J, Graham T, Johansen L, Strange S, Christensen C & Saltin B (1992). Elevated muscle acidity and energy production during exhaustive exercise in humans. Am J Physiol Regul Integr Comp Physiol 263, R891-R899.
3. Bangsbo J, Madsen K, Kiens B & Richter EA (1996). Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man. J Physiol 495, 587-596.
4. 2 consumption-temperature curves during rest and isometric exercise in human skeletal muscle. Comp Biochem Physiol a Mol Integr Physiol 132, 27-32.
5. Bouissou P, Defer G, Guezennec CY, Estrade PY & Serrurier B (1988). Metabolic and blood catecholamine responses to exercise during alkalosis. Med Sci Sports Exerc 20, 228-232.
6. Brimacombe JR, MaCfie AG & McCrirrick A (1991). The extensometer. Potential applications in anaesthesia and intensive care. Anaesthesia 46, 756-761.
7. + pump. Pflugers Arch 430, 909-915.
8. Cairns SP, Ruzhynsky V & Renaud JM (2004). Protective role of extracellular chloride in fatigue of isolated mammalian skeletal muscle. Am J Physiol Cell Physiol 287, C762-C770.
9. + pump regulation and skeletal muscle contractility. Physiol Rev 83, 1269-1324.
10. 3. Int J Sports Med 5, 228-231.
11. Fitts RH (1994). Cellular mechanisms of muscle fatigue. Physiol Rev 74, 49-94.
12. +-ATPase activity in untrained and trained individuals. J Appl Physiol 93, 1650-1659.
13. - cotransport activity. News Physiol Sci 18, 196-200.
14. + in human calf muscle during dynamic exercise: Effect of ischaemia and relation to muscle pain. J Physiol 529, 849-861.
15. Hamann JJ, Buckwalter JB, Clifford PS & Shoemaker JK (2004). Is the blood flow response to a single contraction determined by work performed? J Appl Physiol 96, 2146-2152.
16. Hollidge-Horvat MG, Parolin ML, Wong D, Jones NL & Heigenhauser GJF (2000). Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise. Am J Physiol Endocrinol Metab 278, E316-E329.
17. Iwaoka K, Okagawa S, Mutoh Y & Miyashita M (1989). Effects of bicarbonate ingestion on the respiratory compensation threshold and maximal exercise performance. Jpn J Physiol 39, 255-265.
18. Jahn LA, Barrett EJ, Genco ML, Wei L, Spraggins TA & Fryburg DA (1999). Tissue composition affects measures of postabsorptive human skeletal muscle metabolism: Comparison across genders. J Clin Endocrinol Metab 84, 1007-1010.
19. Johnson LJ, Heigenhauser GJF, Hsia CCW, Jones NL & Wagner PD (1996). Determinants of gas exchange and acid-base balance during exercise. In Handbook of Physiology, Section 12, Exercise: Regulation and Integration of Multiple Systems, ed. Rowell LB & Shepherd JT, pp. 515-584. American Physiological Society.
20. Juel C (1986). Potassium and sodium shifts during in vitro isometric muscle contraction, and the time course of the ion-gradient recovery. Pflugers Arch 406, 458-463.
21. Juel C (1997). Lactate-proton cotransport in skeletal muscle. Physiol Rev 77, 321-358.
22. + in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. Am J Physiol Regul Integr Comp Physiol 278, R400-R406.
23. 3 loading on acid-base balance, lactate concentration, and performance in racing greyhounds. J Appl Physiol 85, 1037-1043.
24. Kowalchuk JM, Heigenhauser GJ, Lindinger MI, Sutton JR & Jones NL (1988). Factors influencing hydrogen ion concentration in muscle after intense exercise. J Appl Physiol 65, 2080-2089.
25. Kristensen M, Albertsen J, Rentsch M & Juel C (2004). Lactate and force production in skeletal muscle. J Physiol 562, 521-526.
26. 2+ uptake. J Appl Physiol 97, 1414-1423.
27. 2+ regulation in human skeletal muscle. J Appl Physiol 92, 912-922.
28. Linderman J & Fahey TD (1991). Sodium bicarbonate ingestion and exercise performance. An update. Sports Med 11, 71-77.
29. 3 loading in humans. Am J Physiol 276, R32-R43.
30. Lindinger MI, Heigenhauser GJF & Spriet LL (1990). Effects of alkalosis on muscle ions at rest and with intense exercise. Can J Physiol Pharmacol 68, 820-829.
31. - distribution in humans during and after high-intensity exercise: Role in muscle fatigue attenuation? J Appl Physiol 78, 765-777.
32. 2 uptake at onset of heavy exercise. J Appl Physiol 90, 83-89.
33. McKenna MJ, Heigenhauser GJF, McKelvie RS, MacDougall JD & Jones NL (1997a). Sprint training enhances ionic regulation during intense exercise in men. J Physiol 501, 687-702.
34. McKenna MJ, Heigenhauser GJF, McKelvie RS, Obminski G, MacDougall JD & Jones NL (1997b). Enhanced pulmonary and active skeletal muscle gas exchange during intense exercise after sprint training in men. J Physiol 501, 703-716.
35. Miller RG, Boska MD, Moussavi RS, Carson PJ & Weiner MW (1988). 31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. Comparison of aerobic and anaerobic exercise. J Clin Invest 81, 1190-1196.
36. Miller BF, Lindinger MI, Fattor JA, Jacobs KA, Leblanc PJ, Duong M, Heigenhauser GJF & Brooks GA (2005). Hematological and acid-base changes in men during prolonged exercise with and without sodium-lactate infusion. J Appl Physiol 98, 856-865.
37. Nielsen HB, Hein L, Svendsen LB, Secher NH & Quistorff B (2002). Bicarbonate attenuates intracellular acidosis. Acta Anaesthesiol Scand 46, 579-584.
38. Nielsen JJ, Mohr M, Klarskov C, Kristensen M, Krustrup P, Juel C & Bangsbo J (2004). Effects of high-intensity intermittent training on potassium kinetics and performance in human skeletal muscle. J Physiol 554, 857-870.
39. Nielsen OB, de Paoli F & Overgaard K (2001). Protective effects of lactic acid on force production in rat skeletal muscle. J Physiol 536, 161-166.
40. Nielsen OB, Hilsted L & Clausen T (1998). Excitation-induced force recovery in potassium-inhibited rat soleus muscle. J Physiol 512, 819-829.
41. Pedersen TH, De Paoli F & Nielsen OB (2005). Increased excitability of acidified skeletal muscle: Role of chloride conductance. J General Physiol 125, 237-246.
42. Pedersen TH, Nielsen OB, Lamb GD & Stephenson DG (2004). Intracellular acidosis enhances the excitability of working muscle. Science 305, 1144-1147.
43. 2 uptake at exercise onset in nonischemic human forearm. J Appl Physiol 91, 2010-2016.
44. +-lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres. Pflugers Arch 442, 197-203.
45. Potteiger JA, Webster MJ, Nickel GL, Haub MD & Palmer RJ (1996). The effects of buffer ingestion on metabolic factors related to distance running performance. Eur J Appl Physiol Occup Physiol 72, 365-371.
46. Prange HD, Shoemaker JL Jr, Westen EA, Horstkotte DG & Pinshow B (2001). Physiological consequences of oxygen dependent chloride binding to hemoglobin. J Appl Physiol 91, 33-38.
47. Putman CT, Jones NL & Heigenhauser GJF (2003). Effects of short-term training on plasma acid-ase balance during incremental exercise in man. J Physiol 550, 585-603.
48. Raymer GH, Marsh GD, Kowalchuk JM & Thompson RT (2004). Metabolic effects of induced alkalosis during progressive forearm exercise to fatigue. J Appl Physiol 96, 2050-2056.
49. Renaud JM, Gramolini A, Light P & Comtois A (1996). Modulation of muscle contractility during fatigue and recovery by ATP sensitive potassium channel. Acta Physiol Scand 156, 2003-2012.
50. 2-drenergic stimulation does not prevent potassium loss from exercising quadriceps muscle. Am J Physiol Reg Int Comp Physiol 258, R1192-R1200.
51. Sabatini S (1996). The cellular basis of metabolic alkalosis. Kidney Int 49, 906-917.
52. + from muscle during prolonged dynamic exercise. Acta Physiol Scand 136, 293-294.
53. Saltin B, Radegran G, Koskolou MD & Roach RC (1998). Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 162, 421-436.
54. + rgulation contributes to exercise limitation in end-stage renal failure. Kidney Int 63, 283-290.
55. Sejersted OM & Sjøgaard G (2000). Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise. Physiol Rev 80, 1411-1481.
56. Sjøgaard G, Adams RP & Saltin B (1985). Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am J Physiol Regul Integr Comp Physiol 248, R190-R196.
57. Stephens TJ, McKenna MJ, Canny BJ, Snow RJ & McConell GK (2002). Effect of sodium bicarbonate on muscle metabolism during intense endurance cycling. Med Sci Sports Ex 34, 614-621.
58. Street D, Nielsen JJ, Bangsbo J & Juel C (2005). Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium. J Physiol 566, 481-489.
59. Sutton JR, Jones NL & Toews CJ (1981). Effect of pH on muscle glycolysis during exercise. Clin Sci 61, 331-338.
60. + alterations in acute respiratory and metabolic alkalosis in dogs. Am J Physiol 258, F305-F310.
61. 2 consumption and blood flow in skeletal muscle. J Appl Physiol 90, 511-519.
62. Van Beekvelt MCP, Shoemaker JK, Tschakovsky ME, Hopman MTE & Hughson RL (2001b). Blood flow and muscle oxygen uptake at the onset and end of moderate and heavy dynamic forearm exercise. Am J Physiol Regul Integr Comp Physiol 280, R1741-R1747.
63. Verbitsky O, Mizrahi J, Levin M & Isakov E (1997). Effect of ingested sodium bicarbonate on muscle force, fatigue, and recovery. J Appl Physiol 83, 333-337.
64. +-pump? Acta Physiol Scand 165, 357-367.
65. Volianitis S & Secher NH (2002). Arm blood flow and metabolism during arm and combined arm and leg exercise in humans. J Physiol 544, 977-984.
66. Vøllestad NK, Hallen J & Sejersted OM (1994). Effect of exercise intensity on potassium balance in muscle and blood of man. J Physiol 475, 359-368.
67. Wasserman K, Stringer WW, Casaburi R & Zhang YY (1997). Mechanism of the exercise hyperkalemia: An alternate hypothesis. J Appl Physiol 83, 631-643.
68. + exchanger. Annu Rev Physiol 55, 289-304.
69. Westerblad H & Lännergren J (1988). The relation between force and intracellular pH in fatigued, single Xenopus muscle fibres. Acta Physiol Scand 133, 83-89.
70. 31P-NMR study. J Appl Physiol 64, 2333-2339.