Ricin A chain reaches the endoplasmic reticulum after endocytosis

Biochemical and Biophysical Research Communications

Volumn 343, Issue 3, 2006, Pages 857-863

  Liu, Qiong ^a,b   Zhan, Jinbiao ^a   Chen, Xinhong ^c   Zheng, Shu ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NINGBO UNIVERSITY   (China)

^c YANGZHOU UNIVERSITY   (China)

Author keywords

Green fluorescent protein; Intracellular transport; Ricin A chain; Translocation

Indexed keywords

GREEN FLUORESCENT PROTEIN; RICIN A;

ANTIBODY LABELING; ANTIGEN ANTIBODY REACTION; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; FEMALE; FLUORESCENCE ANALYSIS; GENE FUSION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LASER MICROSCOPY; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

BLOTTING, WESTERN; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; PLASMIDS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; RICIN;

ESCHERICHIA COLI; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33645909115     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.02.194     Document Type: Article

References (30)

1. Endo Y., and Tsutugi K. RNA N-glycosidase activity of ricin A chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes. J. Biol. Chem. 262 (1987) 8128-8130
2. Zhan J., de Sousa M., Chaddock J.A., Roberts L.M., and Lord J.M. Restoration of lectin activity to a non-glycosylated ricin B chain mutant by the introduction of novel N-glycosylation site. FEBS Lett. 407 (1997) 271-274
3. Schnell R., Staak O., Borchmann P., Schwartz C., Matthey B., Hansen H., Schindler J., Ghetie V., Vitetta E.S., Diehl V., and Engert A. A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma. Clin. Cancer Res. 8 6 (2002) 1779-1786
4. Pincus S.H., Marcotte T.K., Forsyth B.M., and Fang H. In vivo testing of anti-HIV immunotoxins. Methods Mol. Biol. 166 (2001) 277-294
5. Zhan J., Chen Y., Wang K., and Zheng S. Expression of ricin A chain and ricin A chain-KDEL in Escherichia coli. Protein Expr. Purif. 34 (2004) 197-201
6. Miyawaki A. Green fluorescent protein-like proteins in reef Anthozoa animals. Cell Struct. Funct. 27 (2002) 343-347
7. Chalfie M., Tu Y., Euskirchen G., Ward W.W., and Prasher D.C. Green fluorescent protein as a marker for gene expression. Science 263 (1994) 802-805
8. Sandvig K., Garred O., Prydz K., Kozlov J.V., Hansen S.H., and van Deurs B. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Nature 358 (1992) 510-512
9. Chen X.H., Liu Q., and Zhan J.B. Construction and expression of ricin A chain and green fluorescent protein fusion gene in E. coli. Zhejiang Da Xue Xue Bao Yi Xue Ban 34 (2005) 201-206
10. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
11. Vitetta E.S., and Thorpe P.E. Immunotoxins containing ricin or its A chain. Semin. Cell Biol. 2 (1991) 47-58
12. Byers V.S., and Baldwin R.W. Rationale for clinical use of immunotoxins in cancer and autoimmune disease. Semin. Cell Biol. 2 (1991) 59-70
13. Zhan J., Stayton P., and Press O.W. Modification of ricin A chain, by addition of endoplasmic reticulum (KDEL) or Golgi (YQRL) retention sequences, enhances its cytotoxicity and translocation. Cancer Immunol. Immunother. 46 1 (1998) 55-60
14. Hudson T.H., and Neville Jr. D.M. Temporal separation of protein toxin translocation from processing events. J. Biol. Chem. 262 (1987) 16484-16494
15. van Deurs B., Sandvig K., Peterson O.W., Olsnes S., Simons K., and Griffiths G. Estimation of the amount of internalized ricin that reaches the trans-Golgi network. J. Cell Biol. 106 (1988) 253-267
16. Pastan I., Chaudhary V., and FitzGerald D.J. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 61 (1992) 331-354
17. Pelham H.R. Control of protein exit from the endoplasmic reticulum. Annu. Rev. Cell Biol. 5 (1989) 1-23
18. Pelham H.R., Roberts L.M., and Lord J.M. Toxin entry: how reversible is the secretory pathway?. Trends Cell Biol. 2 (1992) 183-185
19. Androlewicz M.J., Anderson K.S., and Cresswell P. Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc. Natl. Acad. Sci. USA 90 (1993) 9130-9134
20. Gilmore R. Protein translocation across the endoplasmic reticulum: a tunnel with toll booths at entry and exit. Cell 75 (1993) 589-592
21. Gorlich D., Hartmann E., Prehn S., and Rapoport T.A. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature 357 (1992) 47-52
22. Wales R., Chaddock J.A., Roberts L.M., and Lord J.M. Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin. Exp. Cell Res. 203 (1992) 1-4
23. Wales R., Roberts L.M., and Lord J.M. Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells. J. Biol. Chem. 268 (1993) 23986-23990
24. Sandvig K., and van Deurs B. Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin. FEBS Lett. 529 (2002) 49-53
25. Sandvig K., Grimmer S., Lauvrak S.U., Torgersen M.L., Skretting G., van Deurs B., and Iversen T.G. Pathways followed by ricin and Shiga toxin into cells. Histochem. Cell Biol. 117 (2002) 131-141
26. Sandvig K., and van Deurs B. Membrane traffic exploited by protein toxins. Annu. Rev. Cell Dev. Biol. 18 (2002) 1-24
27. Lauvrak S.U., Llorente A., Iversen T.G., and Sandvig K. Selective regulation of the Rab9-independent transport of ricin to the Golgi apparatus by calcium. J. Cell Sci. 115 (2002) 3449-3456
28. Sandvig K., Spilsberg B., Lauvrak S.U., Torgersen M.L., Iversen T.G., and van Deurs B. Pathways followed by protein toxins into cells. Int. J. Med. Microbiol. 293 (2004) 483-490
29. Lauvrak S.U., Torgersen M.L., and Sandvig K. Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin. J. Cell Sci. 117 (2004) 2321-2331
30. Rapak A., Falnes P.O., and Olsnes S. Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc. Natl. Acad. Sci. USA 94 (1997) 3783-3788