Herpes simplex virus and Epstein-Barr virus infections in pregnancy: consequences of neonatal or intrauterine infection

Reproductive Toxicology

Volumn 21, Issue 4, 2006, Pages 436-445

  Avgil, Meytal ^a   Ornoy, Asher ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

EBV; HSV; Neonatal infection; Placental damage

Indexed keywords

ACICLOVIR; FAMCICLOVIR; VALACICLOVIR;

ABORTION; BRAIN DAMAGE; CESAREAN SECTION; CHORIORETINITIS; CLINICAL FEATURE; CONGENITAL MALFORMATION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG SAFETY; EPSTEIN BARR VIRUS; GENITAL HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNE RESPONSE; INCIDENCE; INFECTION PREVENTION; INTRAUTERINE INFECTION; LABORATORY DIAGNOSIS; MICROPHTHALMIA; NEWBORN DISEASE; NEWBORN INFECTION; NONHUMAN; PERINATAL INFECTION; PLACENTA DISORDER; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PREVALENCE; PRIMARY INFECTION; PROGNOSIS; REVIEW; SEROCONVERSION; SERODIAGNOSIS; SEROLOGY; SEROPREVALENCE; SKIN SCAR; STILLBIRTH; SUPERINFECTION; TREATMENT OUTCOME; TREATMENT PLANNING; VIRUS CULTURE; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS REACTIVATION; VIRUS TRANSMISSION;

CERVIX UTERI; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FETAL DISEASES; HERPES SIMPLEX; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 4; SIMPLEXVIRUS;

EID: 33645883835     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.11.014     Document Type: Review

References (79)

1. Pebody R.G., Andrews N., Brown D., Gopal R., De Melker H., Francois G., et al. The seroepidemiology of herpes simplex virus types 1 and 2 in Europe. Sex Transm Infect 80 (2004) 185-191
2. Xu F., Schillinger J.A., Sternberg M.R., Johnson R.E., Lee F.K., Nahmias A.J., et al. Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988-1994. J Infect Dis 185 (2002) 1019-1024
3. Desselberger U. Herpes simplex virus infection in pregnancy: diagnosis and significance. Intervirology 41 (1998) 185-190
4. Bunzli D., Wietlisbach V., Barazzoni F., Sahli R., and Meylan P.R. Seroepidemiology of herpes simplex virus types 1 and 2 in Western and Southern Switzerland in adults aged 25-74 in 1992-1993: a population-based study. BMC Infect Dis 4 1 (2004) 10
5. Benedetti J., Corey L., and Ashley R.L. Recurrence rate in genital herpes after symptomatic first-episode infection. Ann Internal Med 121 (1994) 847-854
6. Wald A., Zeh J., Selke S., Ashley R.L., and Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med 333 (1995) 770-775
7. Corey L., and Handsfield H.H. Genital herpes and public health: addressing a global problem. JAMA 283 (2000) 791-794
8. Fonnest G., de la Fuente Fonnest I., and Weber T. Neonatal herpes in Denmark. Acta Obstet Gynaecol Scand 76 (1997) 355-358
9. Gutierrez K.M., Halpern M.S.F., Maldonado Y., and Arvin A.M. The epidemiology of neonatal herpes simplex virus infections in California from 1985 to 1995. J Infect Dis 180 (1999) 199-202
10. Corey L., Whitley R.J., Stone E.F., and Mohan K. Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome. Lancet 1 (1988) 1-4
11. Arvin A.M. Herpes simplex infections. In: Klein R. (Ed). Infectious diseases of the fetus and newborn infant. 5th ed. (2001), W.B. Saunders Company, Philadelphia 425-446
12. Mansour A.M., and Nichols M.M. Congenital diffuse necrotizing herpetic retinitis. Graefes Arch Clin Exp Ophthalmol 231 (1993) 95-98
13. Brown Z.A., Wald A., Morrow R.A., Selke S., Zeh J., and Corey L. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA 289 (2003) 203-209
14. Arvin A.M. The epidemiology of perinatal herpes simplex virus infection. In: Stanberry L.R. (Ed). Genital and neonatal herpes (1996), Wiley, Chichester 179-192
15. Prober C.G., Corey L., Brown Z.A., Hensleigh P.A., Frenkel L.M., Bryson Y.J., et al. The management of pregnancies complicated by genital infections with herpes simplex virus. Clin Infect Disease 15 (1992) 1031-1038
16. Jones C.L. Herpes simplex virus infection in the neonate: clinical presentation and management. Neonatal Network 15 (1996) 11-15
17. Gaytant M.A., Steegers E.A.P., van Cromvoirt P.L.M., Semmekrot B.A., and Galama J.M.D. The incidence of neonatal herpes in The Netherlands. Ned Tijdschr Geneeskd 144 (2000) 1832-1836
18. Overall J.C. Herpes simplex virus infection of the fetus and newborn. Pediatr Ann 23 (1994) 131-136
19. Fleming D.T., McQuillan G.M., Johnson R.E., Nahmias A.J., Aral S.O., Lee F.K., et al. Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med 337 (1997) 1105-1111
20. Hammerberg O., Watts J., Chernesky M., Luchsinger I., and Rawls W. An outbreak of herpes simplex virus type 1 in an intensive care nursery. Pediatr Infect Dis J 2 (1983) 290-294
21. Gesundheit B., Grisaru-Soen G., Greenberg D., Levtzion-Korach O., Malkin D., Petric M., et al. Neonatal genital herpes simplex virus type 1 infection after Jewish ritual circumcision: modern medicine and religious tradition. Pediatrics 114 (2004) 259-263
22. Dan M., Sadan O., Glezerman M., Raveh D., and Samra Z. Prevalence and risk factors for herpes simplex virus type 2 infection among pregnant women in Israel. Sex Transm Dis 30 11 (2003) 835-838
23. Gaytant M.A., Steegers E.A.P., Van Laere M., Semmekrot B.A., Groen J., Weel J.F., et al. Seroprevalences of herpes simplex virus type 1 and type 2 among pregnant women in The Netherlands. Sex Transm Dis 29 11 (2002) 710-713
24. Brown Z.A., Selke S., Zeh J., Kopelman J., Maslow A., Ashley R.L., et al. The acquisition of herpes simplex virus during pregnancy. New Engl J Med 337 (1997) 509-515
25. Crosby R.A., DiClemente R.J., Wingood G.M., and Rose E. Testing for HSV-2 infection among pregnant teens: implications for clinical practice. J Pediatr Adolesc Gynecol 16 (2003) 39-41
26. Brocklehurst P. Update on the treatment of sexually transmitted infections in pregnancy-2. Int J STD AIDS 10 (1999) 141-144
27. Brown Z.A., Benedetti J., Ashley R., Burchett S., Selke S., Berry S., et al. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 324 (1991) 1247-1252
28. Prober C.G., Hensleigh P.A., Boucher F.D., Yasukawa L.L., Au D.S., and Arvin A.M. Use of viral cultures at delivery to identify neonates exposed to herpes simplex virus. N Engl J Med 318 (1988) 887-891
29. Arvin A.M., Hensleigh P.A., Prober C.G., Au D.S., Yasukawa L.L., Wittek A.E., et al. Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex virus at delivery. New Engl J Med 315 (1986) 796-800
30. Hensleight P.A., Andrews W.W., Brown Z., Greenspoon J., Yasukawa L., and Prober C.G. Genital herpes during pregnancy: inability to distinguish primary and recurrent infections clinically. Obstet Gynecol 89 (1997) 891-895
31. Whitley RJ. Herpes simplex virus infections. In: Remington JS, Klein OJ, editors. Infectious disease of the fetus and newborn infants. 3rd ed. Philadelphia, PA: The W.B. Saunders Co.
32. Kimberlin D.W. Neonatal herpes simplex infection. Clin Microbiol Rev 17 1 (2004) 1-13
33. Brown Z.A., Vontver L.A., Benedetti J., Critclow C.W., Sells C.J., Berry S., and Corey L. Effect on infants of a first episode of genital herpes during pregnancy. N Eng J Med 317 (1987) 1246-1251
34. Brown Z.A. HSV-2 specific serology should be offered routinely to antenatal patients. Rev Med Virol 10 (2000) 141-144
35. Hutto C., Arvin A., Jacobs R., Steele R., Stagno S., Lyrene R., et al. Intrauterine herpes simplex virus infections. J Pediatr 110 (1987) 97-101
36. Karesh J.W., Kapur S., and MacDonald M. Herpes simplex virus and congenital malformations. South Med J 76 (1983) 1561-1563
37. Johansson A.B., Rassart A., Blum D., Van Beers D., and Liesnard C. Lower-limb hypoplasia due to intrauterine infection with herpes simplex virus type 2: possible confusion with intrauterine Varicella-Zoster syndrome. Clin Infect Dis 38 (2004) 57-62
38. Lee A., Bar-Zeev N., Walker S.P., and Permezel M. In utero herpes simplex encephalitis. Obstet Gynecol 102 5 (2003) 1197-1199
39. Barefoot K.H., Little G.A., and Ornvold K.T. Fetal demise due to herpes simplex virus: an illustrated case report. J Perinatol 22 1 (2002) 86-88
40. Corey R., and Flynn J.T. Maternal intrauterine herpes simplex virus leading to persistent fetal vasculature. Arch Ophthalmol 118 (2000) 837-840
41. Sarkell B., Blaylock W.K., and Vernon H. Congenital neonatal herpes simplex virus infection. J Am Acad Dermatol 27 (1992) 817-821
42. Harris H.H., Foucar E., Andersen R.D., and Ray T.L. Intrauterine herpes simplex infection resembling mechanobullous disease in a newborn infant. J Am Acad Dermatol 15 (1986) 1148-1155
43. Beers B.B., Flowers F.P., Sherertz E.F., and Selden S. Dystrophic calcinosis cutis secondary to intrauterine herpes simplex. Pediatr Dermatol 3 3 (1986) 208-211
44. Tomer A., and Harel A. Congenital absence of scalp skin and herpes simplex virus. A case report. Isr J Med Sci 19 10 (1983) 950-951
45. Granat M., Morag A., Margalioth E.J., Leviner E., and Ornoy A. Fetal outcome following primary herpetic gingivostomatitis in early pregnancy. Morphological study and updated appraisal. Isr J Med Sci 22 6 (1986) 455-459
46. Hyde S.R., and Giacoia G.P. Congenital herpes infection: placental and umbilical cord findings. Obstet Gynecol 81 (1993) 852-855
47. Koi H., Zhang J., Makrigiannakis A., Getsios S., MacCalman C.D., Strauss III J.F., and Parry S. Syncytiotrophoblast is a barrier to maternal-fetal transmission of herpes simplex virus. Biol Reprod 67 5 (2002) 1572-1579
48. Gronroos M., Honkonen E., Terho P., and Punnonen R. Cervical and serum IgA and serum IgG antibodies to Chlamydia trachomatis and herpes simplex virus in threatened abortion: a prospective study. Br J Obstet Gynaecol 90 (1983) 167-170
49. Schust D.J., Hill A.B., and Ploegh H.L. Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells. J Immunol 157 (1996) 3375-3380
50. Parry S., Holder J., Halterman M.W., Weitzman M.D., Davis A.R., Federoff H., and Strauss III J.F. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol 152 (1998) 1521-1529
51. McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J Infect Dis 15;190(4):2004:826-34.
52. Malkin J.E., and Beumont M.G. Herpes simplex virus infection in pregnancy. Herpes 6 (1999) 50-54
53. Braig S., Luton D., Sibony O., Edlinger C., Boissinot C., Blot P., et al. Acyclovir prophylaxis in late pregnancy prevents recurrent genital herpes and viral shedding. Eur J Obstet Gynecol Reprod Biol 96 1 (2001) 55-58
54. Baker DA. American College for Obstetricians and Gynecologists Management of herpes in pregnancy. Practice Bulletin No. 8. Washington, DC: American College of Obstetricians and Gynecologists; 1999.
55. Whitley R.J., Corey L., Arvin A., Lakeman F.D., Sumaya C.V., Wright P.F., et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 158 (1988) 109-116
56. Whitley R., Arvin A., Prober C., Corey L., Burchett S., Plotkin S., et al. Predictors of morbidity and mortality in neonates with herpes simplex virus infections. The National Institute of Allergy and Infectious Disease Collaborative Antiviral Study Group. N Engl J Med 324 (1991) 450-454
57. Spangler J.G., Kirk J.K., and Knudson M.P. Uses and safety of acyclovir in pregnancy. J Family Pract 38 2 (1994) 186-191
58. Wald A., Zeh J., Barnum G., Davis L.G., and Corey L. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Ann Int Med 124 (1996) 8-15
59. Wald A., Corey L., Cone R., Hobson A., Davis G., and Zeh J. Frequent genital herpes simplex virus 2 shedding in immunocompetent women: effect of acyclovir treatment. J Clin Invest 99 (1997) 1092-1097
60. Andrews E.B., Yankaskas B.C., Cordero J.F., Schoeffler K., and Hampp S. Acyclovir in pregnancy registry: six years' experience. The Acyclovir in Pregnancy Registry Advisory Committee. Obstet Gynecol 79 1 (1992) 7-13
61. Stone K.M., Reiff-Eldridge R., White A.D., Cordero J.F., Brown Z., Alexander E.R., et al. Pregnancy outcomes following systemic prenatal acyclovir exposure: conclusions from the international acyclovir pregnancy registry, 1984-1999. Birth Defects Res Part A Clin Mol Teratol 70 4 (2004) 201-207
62. Sheffield J.S., Hollier L.M., Hill J.B., Stuart G.S., and Wendel G.D. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. Obstet Gynecol 102 6 (2003) 1396-1403
63. Behrman R.E., Kliegman R.M., and Arvin A.M. Nelson textbook of pediatrics. 15th ed. (1996), W.B. Saunders Co. pp. 897-901
64. Rahman M.A., Kingsley L.A., Atchison R.W., Belle S., Breinig M.C., Ho M., et al. Reactivation of Epstein-Barr virus during early infection with human immunodeficiency virus. J Clin Microbiol 29 (1991) 1215-1220
65. Telenti A., Vehlinger D.E., Marchesi F., German D., Malinverni R., and Matter L. Epstein-Barr virus infection in HIV-positive patients. Eur J Clin Microbiol Infect Dis 12 (1993) 601-609
66. Purtilo D.T., and Sakamoto K. Reactivation of Epstein-Barr virus in pregnant women: social factors, and immune competence as determinants of lymphoproliferative diseases - a hypothesis. Med Hypotheses 8 4 (1982) 401-408
67. Meyohas M.C., Marechal V., Desire N., Bouillie J., Frottier J., and Nicolas J.C. Study of mother-to-child Epstein-Barr virus transmission by means of nested PCRs. J Virol 70 10 (1996) 6816-6819
68. Icart J., Didier J., Dalens M., Chabanon G., and Boucays A. Prospective study of Epstein Barr virus (EBV) infection during pregnancy. Biomedicine 34 3 (1981) 160-163
69. Costa S., Barrasso R., Terzano P., Zerbini M., Carpi C., and Musiani M. Detection of active Epstein-Barr infection in pregnant women. Eur J Clin Microbiol 4 3 (1985) 335-336
70. Fleisher G., and Bologonese R. Epstein-Barr virus infections in pregnancy: a prospective study. J Pediatr 104 3 (1984) 374-379
71. Le C.T., Chang R.S., and Lipson M.H. Epstein-Barr virus infections during pregnancy. A prospective study and review of the literature. Am J Dis Child 137 5 (1983) 466-468
72. Fleisher G., and Bolognese R. Persistent Epstein-Barr virus infection and pregnancy. J Infect Dis 147 6 (1983) 982-986
73. Brown Z.A., and Stenchever M.A. Infectious mononucleosis and congenital anomalies. Am J Obstet Gynecol 131 1 (1978) 108-109
74. Goldberg G.N., Fulginiti V.A., Ray C.G., Ferry P., Jones J.F., Cross H., et al. In utero Epstein-Barr virus (infectious mononucleosis) infection. JAMA 246 14 (1981) 1579-1581
75. Lehtinen M., Koskela P., Ögmundsdottir H.M., Bloigu A., Dillner J., Gudnadottir M., et al. Maternal herpesvirus infections and risk of acute lymphoblastic leukemia in the offspring. Am J Epidemiol 158 (2003) 207-213
76. Fleisher G., and Bologonese R. Infectious mononucleosis during gestation: report of three women and their infants studied prospectively. Pediatr Infect Dis 3 4 (1984) 308-311
77. Ornoy A., Dudai M., and Sadovsky E. Placental and fetal pathology in infectious mononucleosis. Diagn Gynecol Obstet 4 (1982) 11-16
78. Schuster V., Janssen W., Seidenspinner S., and Kreth H.W. Congenital Epstein-Barr virus infection. Monatsschr Kinderheilkd 141 5 (1993) 401-404
79. Weaver L.T., Nelson R., and Bell T.M. The association of extrahepatic bile duct atresia and neonatal Epstein-Barr virus infection. Acta Paediatr Scand 73 1 (1984) 155-157