Growth hormone-releasing factor: Structural modification or protection for more potent analogs

Combinatorial Chemistry and High Throughput Screening

Volumn 9, Issue 3, 2006, Pages 171-174

  Dubreuil, Pascal ^a   Désévaux, Cyril ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Analogs; Growth hormone releasing factor

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; TH 9507; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DEGRADATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; ENZYMATIC DEGRADATION; HIV ASSOCIATED LIPODYSTROPHY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; GROWTH HORMONE-RELEASING HORMONE; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

EID: 33645877083     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620706776055511     Document Type: Review

References (54)

1. Guillemin, R.; Brazeau, P.; Böhlen, P.; Esch, F.; Ling, N.; Wehrenberg, W.B. Science, 1982, 218, 585-7.
2. Guillemin, R.; Zeytin, F.; Ling, N.; Bohlen, P.; Esch, F.; Brazeau, P.; Bloch, B.; Wehrenberg, W.B. Proc. Soc. Exp. Biol. Med., 1984, 175, 407-13.
3. Esch, F.S.; Böhlen, P.; Ling, N.C.; Brazeau, P.; Wehrenberg, W.B.; Guillemin, R. J. Biol. Chem., 1983, 258, 1806-10.
4. Ling, N.; Brazeau, P. Endocrinology, 1983, 112, A205.
5. Su, C.M.; Jensen, R.L.; Heimer, E.P.; Felix, A.M.; Pan, Y.C.; Mowles, T.F. Horm. Metab. Res., 1991, 23, 15-21.
6. Rivier, J.; Spiess, J.; Thorner, M.; Vale, W. Nature, 1982, 300, 276-8.
7. Brazeau, P.; Ling, N.; Böhlen, P.; Esch, F.; Hing, S.Y.; Guillemin, R. Proc. Natl. Acad. Sci. USA, 1982, 79, 7909-13.
8. Dubreuil, P.; Petitclerc, D.; Gaudreau, P.; Brazeau, P.; Pelletier, G. Domest. Anim. Endocrinol., 1991, 8, 307-21.
9. Frohman, L.A.; Downs, T.R.; Williams, T.C.; Heimer, E.P.; Yu-Ching, E.P.; Felix, A.M. J. Clin. Invest., 1986, 78, 906-13.
10. Dubreuil, P.; Petitclerc, D.; Pelletier, G.; Gaudreau, P., Farmer C., Mowles T.F., Brazeau P. J. Anim. Sci., 1990, 68, 1254-68.
11. Lapierre, H.; Pelletier, G.; Petitclerc, D.; Gaudreau, P.; Dubreuil, P.; Mowles, T.F.; Brazeau, P. Can. J. Anim. Sci., 1990, 70, 525-535.
12. Dubreuil, P.; Brazeau, P.; Moreau, S.; Farmer, C.; Coy, D.; Abribat, T. Growth Horm. IGF Res., 2001, 11, 173-86.
13. Dubreuil, P.; Pelletier, G.; Petitclerc, D.; Lapierre, H.; Couture, Y.; Brazeau, P.; Gaudreau, P.; Morrisset, J. J. Domest. Anim. Endocrinol., 1987, 4, 299-307.
14. Blackman, M.R.; Vittone, J.; Corpas, E. Growth hormone releasing hormone: effects in healthy elderly men, Growth Hormone Secretagogues, Int. Sereno Symp. USA, 1994, 23.
15. Ballard, J.; Baxter, R.; Binoux, M.; Clemmons, D.; Drop, S.; Hall, K.; Hintz, R.; Rechler, M.; Rutanen, E.; Schwander, J. Acta Endocrinol., 1989, 121, 751-2.
16. Eden, S.; Bengtsson, B.A.; Oscarsson, J. Acta Paediatr. Scand. Suppl., 1990, 367, 14-9.
17. Abribat, T.; Chapdelaine, A.; Gravel, D.; Dubreuil, P.; Ibea, M.; Brazeau, P. Proc. Europ. Congress Endocrinol., Turin, Italy, 2001a, O-93.
18. Abribat, T.; Chapdelaine, A.; Gravel, D.; Brazeau, P.; Aumais, C. Proc. Endoc. Soc., Denver, CO, USA, 2001b, 292.
19. Coy, D.H.; Hocart, S.J.; Murphy, W.A. Eur. J. Pharmacol., 1991, 204, 179-85.
20. Felix, A.M.; Heimer, E.P.; Mowles, T.F.; Eisenbeis, H.; Leung, P.; Lambros, T.J.; Ahmad, M.; Wang, C-T. In Peptides; Theodoropoulos D, Ed.; Walter de Gruyter: New York:, 1986; pp. 481-4.
21. Felix, A.M.; Heimer, E.P.; Wang, C.-T.; Lambros, T.J.; Fournier, A.; Mowles, T.F.; Maines, S.; Campbell, R.M.; Wegrzynski, B.B.; Toome, V.; Fry, D.; Madison, V.S. Int. J. Pept. Protein Res., 1988, 32, 441-54.
22. Gaudreau, P.; Boulanger, L.; Abribat, T. J. Med. Chem., 1992, 35, 1864-9.
23. Izdebski, J.; Pinski, J.; Horvath, J.E.; Halmos, G.; Groot, K.; Schally, A.V. Proc. Natl. Acad. Sci. USA, 1995, 92, 4872-6.
24. Kubiak, T.M.; Kelly, C.R.; Krabill, L.F. Drug Metab. Dispos., 1989, 17, 393-7.
25. Sato, K.; Hotta, M.; Kageyama, J.; Chiang, T.-C.; Hu, H.-Y.; Dong, M.-H.; Ling, N. Biochem. Biophys. Res. Commun., 1987, 49, 531-7.
26. Zarandi, M.; Serfozo, P.; Zsigo, J.; Bokser, L.; Janaky, T.; Olsen, D.B.; Bajusz, S.; Schally, A.V. Int. J. Pept. Protein Res., 1992, 39, 211-7.
27. Bokser, L.; Zarandi, M.; Schally, A.V. Life Sci., 1989, 46, 999-1005.
28. Coy, D.H.; Murphy, W.A.; Sueiras-Diaz, J.; Coy, E.J.; Lance, V.A. J. Med. Chem., 1985, 28, 181-5.
29. Gulyas, J.; Bajusz, S.; Kovacs, M.; Schally, A.V. In Peptide Chemistry, Biology. Interactions with Proteins; Penke B.; Torok A., Ed., Walter de Gruyter: New York, 1988; pp. 113-6.
30. Kovacs, M.; Gulyas, J.; Bajusz, S.; Schally, A.V. Life Sci., 1988, 42, 27-35.
31. Lance, V.A.; Murphy, W.A.; Sueiras-Diaz, J.; Coy, D.H. Biochem. Biophys. Res. Commun., 1984, 119, 265-72.
32. Ling, N.; Baird, A.; Wehrenberg, W.B.; Ueno, N.; Munegumi, T.; Brazeau, P. Biochem. Biophys. Res. Commun., 1984, 123, 854-61.
33. Ling, N.; Baird, A.; Wehrenberg, W.B.; Ueno, N.; Munegumi, T.; Regno, T.C.; Brazeau, P. Biochem. Biophys. Res. Commun., 1984, 122, 304-10.
34. Zarandi, M.; Csernus, V.; Bokser, L.; Bajusz, S.; Groot, K.; Schally, A.V. Int. J. Pept. Protein Res., 1990, 36, 499-505.
35. Zarandi, M.; Serfozo, P.; Zsigo, J.; Deutch, A.H.; Janaky, T.; Olsen, D.B.; Bajusz, S.; Schally, A.V. Pept. Res., 1992, 5, 190-3.
36. Ling, N.; Baird, A.; Wehrenberg, W.B.; Ueno, N.; Munegumi, T.; Brazeau, P. Biochem. Biophys. Res. Commun., 1984, 123, 854-61.
37. Campbell, R.M.; Lee, Y.; Rivier, J.; Heimer, E.P.; Felix, A.M.; Mowles, T.F. Peptides, 1991, 12, 569-74.
38. Campbell, R.M.; Lee, Y.; Mowles, T.; McIntyre, K.W.; Ahmad, M.; Felix, A.; Heimer, E. Peptides, 1992, 13, 787-93.
39. Petitclerc, D.; Pelletier, G.; Lapierre, H.; Gaudreau, P.; Couture, Y.; Dubreuil, P.; Morisset, J.; Brazeau, P. J. Anim. Sci., 1987, 65, 996-1005.
40. Felix, A.M.; Lambros, T.; Heimer, E.P.; Cohen, H.; Pan, Y.-C.; Campbell, R.; Bongers, J.. Peptides 1990, Giralt E. and Andreu D. Eds., ES-COM Publishers BV, Leiden, 1991; p .732.
41. Friedman, A.R.; Ichhpurani, A.K.; Brown, D.M.; Hillman, R.M.; Zurcher-Neely, H.A.; Guido, D.M. Peptides: Chemistry, Structure and Biology, ES-COM Publishers BV: Leiden, 1990.
42. Bongers, J.; Heimer, E.P.; Lambros, T.L.; Pan, Y.C.; Campbell, R.M.; Felix, A.M. Int. J. Pept. Protein Res., 1992, 39, 364-74.
43. Friedman, A.R.; Ichhpurani, A.K.; Brown, D.M.; Hillman, R.M.; Krabill, L.F.; Martin, R.A.; Zurcher-Neely, H.A.; Guido, D.M. Int. J. Pept. Protein Res., 1991, 37, 14-20.
44. Su, C.M.; Jensen, L.; Heimer, E.P.; Felix, A.M.; Pan, Y.-C.; Mowles, T.F. Horm. Metab. Res., 1991, 23, 15-21.
45. Frohman, L.A.; Downs, T.R.; Heimer, E.P.; Felix, A.M. J. Clin. Invest., 1989, 83, 1533-40.
46. Campbell, R.M.; Stricker, P.; Miller, R.; Bongers, J.; Liu, W.; Lambros, T.; Ahmad, M.; Felix, A.; Heimer, E. Peptides, 1994, 15, 489-495.
47. Heimer, E.P.; Bongers, J.; Ahmad, M.; Lambros, T.; Campbell, R.M.; Felix, A.M. Peptides: Chemistry and Biology, ESCOM Publishers BV: Leiden, 1992.
48. Rizo, J.; Gierasch, L.M. Ann. Rev. Biochem., 1992, 61, 387-418.
49. Campbell, R.M.; Su, C.M.; Maines, S.L.; Stricker, P.R.; Jensen, L.R.; Heimer, E.P.; Felix, A.M.; Mowles, T.F. J. Anim. Sci., 1988, 66 (Suppl. 1), 291.
50. Ibea, M.; Brazeau, P.; Abribat, T. US patent Nos 5,817,627; 5,861,379 and 5,939,386.
51. Gravel, D.; Brazeau, P. US patent No 6,458,764B1.
52. Désévaux, C.; Dubreuil, P.; Lenaerts, V.; Girard C. Int. J. Pharm., 2002, 63, 772-9.
53. Kojima, M.; Hosoda, H.; Date, Y.; Nakazato, M.; Matsuo, H.; Kangawa, K. Nature, 1999, 402, 656-60.
54. Falutz, J.; Allas, S.; Kotler, D.; Thompson, M.; Koutkia, P.; Albu, J.; Trottier, B.; Routy, J.P.; Cote, P.; Abribat, T.; Grinspoon, S. AIDS, 2005, 19, 1279-1287.