IgG isotype conversion of a novel human anti-carcinoembryonic antigen antibody to increase its biological activity

Anticancer Research

Volumn 26, Issue 2 A, 2006, Pages 1057-1063

  Huang, Jian ^a   Shibaguchi, Hirotomo ^a   Zhao, Jun ^a   Luo, Naixiang ^a   Kuroki, Motomu ^a   Kinugasa, Tetsushi ^a   Hirose, Yumiko ^a   Yamada, Hiromi ^a   Kuroki, Masahide ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

ADCC; CDC; CEA; HmAb; Immunotherapy; Isotype conversion

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIBODY; IMMUNOGLOBULIN G;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN BINDING; ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; FLOW CYTOMETRY; GENETIC TRANSFECTION; MOLECULAR CLONING; PRIORITY JOURNAL; TUMOR CELL; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; CHO CELLS; CLONING, MOLECULAR; COMPLEMENT SYSTEM PROTEINS; CRICETINAE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; KILLER CELLS, LYMPHOKINE-ACTIVATED; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 33645834571     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Clynes RA, Towers TL, Presta LG and Ravetch JV: Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6: 443-446, 2000.
2. Carter P: Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 1: 118-129, 2001.
3. Wels W, Biburger M, Muller T, Dalken B, Giesubel U, Tonn T and Uherek C: Recombinant immunotoxins and retargeted killer cells: employing engineered antibody fragments for tumor-specific targeting of cytotoxic effectors. Cancer Immunol Immunother 53: 217-226, 2004.
4. Kuroki Ma, Shibaguchi H, Imakiire T, Uno K, Shirota K, Higuchi T, Shitama T, Yamada H, Hirose Y, Nagata A and Kuroki Mo: Immunotherapy and gene therapy of cancer using antibodies or their genes against tumor-associated antigens. Anticancer Res 23: 4377-4381, 2003.
5. Prang N, Preithner S, Brischwein K, Goster P, Woppel A, Muller J, Steiger C, Peters M, Baeuerle PA and da Silva AJ: Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines. Br J Cancer 92: 342-349, 2005.
6. Kuroki Ma, Ueno A, Matsumoto H, Abe H, Li T, Imakiire T, Yamauchi Y, Uno K, Shirota K, Shibaguchi H and Kuroki Mo: Significance of tumor-associated antigens in the diagnosis and therapy of cancer: an overview. Anticancer Res 22: 4255-4264, 2002.
7. Groen TP: Tumor-associated antigens. In: Tumor Immunology; Mechanisms, Diagnosis, Therapy. Den Otter W and Ruitenberg EJ (eds.). Amsterdam, Elsevier, pp. 13-27, 1987.
8. Gold P and Freedman SO: Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122: 467-481, 1965.
9. Ishida I, Tomizuka K, Yoshida H, Tahara T, Takahashi N, Ohguma A, Tanaka S, Umehashi M, Maeda H, Nozaki C, Halk E and Lonberg N: Production of human monoclonal and polyclonal antibodies in TransChromo animals. Cloning Stem Cells 4: 91-102, 2002.
10. Imakiire T, Kuroki Mo, Shibaguchi H, Abe H, Yamauchi Y, Ueno A, Hirose Y, Yamada H, Yamashita Y, Shirakusa T, Ishida I and Kuroki Ma: Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen. Int J Cancer 108: 564-570, 2004.
11. Shibaguchi H, Kuroki Ma, Kuroki Mo, Badran A, Hachimine K and Kinugasa T: Cloning and sequencing of variable region cDNA of a novel human monoclonal antibody to carcinoembryonic antigen, and generation of a single chain variable fragmented antibody. Anticancer Res 24: 3355-3360, 2004.
12. Arakawa F, Yamamoto T, Kanda H, Watanabe T and Kuroki M: cDNA sequence analysis of monoclonal antibody FU-MK-1 specific for a transmembrane carcinoma-associated antigen, and construction a mouse/human chimeric antibody. Hybridoma 18: 131-138, 1999.
13. Liang M, Dübel S, Li D, Queitsch I, Li W and Bautz EK: Baculovirus expression cassette vectors for rapid production of complete human IgG from phage display selected antibody fragments. J Immunol Methods 247: 119-130, 2001.
14. Khare PD, Liao S, Kuroki Mo, Hirose Y, Arakawa F, Nakamura K, Tomita Y and Kuroki Ma: Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. Cancer Res 61: 370-375, 2001.
15. Arakawa F, Haruno M, Kuroki Ma, Kanda H, Watanabe T, Misumi Y and Matsuoka Y: Construction and expression of two mouse-human chimeric antibodies with high specificity and affinity for carcinoembryonic antigen. Hybridoma 12: 365-379, 1993.
16. Liao S, Khare PD, Arakawa F, Kuroki M, Hirose Y, Fujimura S, Tomita Y and Kuroki M: Targeting of LAK activity to CEA-expressing tumor cells with an anti-CEA scFv/IL-2 fusion protein. Anticancer Res 21: 1673-1680, 2001.
17. Shibaguchi H, Arakawa F, Imakiire T, Kuroki M and Kuroki M: cDNA cloning and sequencing of a novel monoclonal antibody to carcinoembryonic antigen and construction of a mouse/human chimeric antibody. Anticancer Res 23: 4383-4388, 2003.
18. Naundorf S, Preithner S, Mayer P, Lippold S, Wolf A, Hanakam F, Fichtner I, Kufer P, Raum T, Riethmuller G, Baeuerle PA and Dreier T: In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment. Int J Cancer 100: 101-110, 2002.
19. Roitt JB and Male D: Immunology, 6th ed., London: Mosby, pp. 65-86, 2001.
20. Kamigaki T, Ohyanagi H, Yamamoto M, Kaneda T, Goto T, Ohmura T, Yokoyama K and Saitoh Y: Development and characterization of chimeric anti-carcinoembryonic antigen monoclonal antibodies and their Fab fragments. Jpn J Cancer Res 85: 298-305, 1994.
21. Clynes R, Takechi Y, Moroi Y, Houghton A and Ravetch JV: Fc receptors are required in passive and active immunity to melanoma. Proc Natl Acad Sci USA 95: 652-656, 1998
22. Haruno M, Kuroki Ma, Arakawa F, Kanda H, Watanabe T and Matsuoka Y: In vitro and in vivo characterization of two mouse-human chimeric antibodies with high specificity and affinity for carcinoembryonic antigen. Antibody Immunoconj Radiopharm 7: 133-148, 1994.