Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts

FASEB Journal

Volumn 20, Issue 3, 2006, Pages 562-564

  Fineschi, Serena ^a   Reith, Walter ^a   Guerne, Pierre André ^a   Dayer, Jean Michel ^a   Chizzolini, Carlo ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BORTEZOMIB; COLLAGEN TYPE 1; CYTOKINE; PROTEASOME INHIBITOR; PROTEIN C JUN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; ACETYLCYSTEINE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; BORONIC ACID DERIVATIVE; DRUG DERIVATIVE; INTERSTITIAL COLLAGENASE; LACTACYSTIN; LEUPEPTIN; MESSENGER RNA; PROTEASOME; PYRAZINE DERIVATIVE; RNA POLYMERASE II; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; BIOSYNTHESIS; CYTOLOGY; DOSE RESPONSE; DOWN REGULATION; DRUG ANTAGONISM; FIBROBLAST; FIBROSIS; GENETICS; METABOLISM; ONCOGENE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SKIN; UPREGULATION;

ACETYLCYSTEINE; ANTHRACENES; BORONIC ACIDS; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBROSIS; GENES, JUN; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUPEPTINS; MATRIX METALLOPROTEINASE 1; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-JUN; PYRAZINES; RNA POLYMERASE II; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SKIN; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 33645805628     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4870fje     Document Type: Article

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